Abstract:
:Certolizumab pegol (Cimzia(®)) is currently the only PEGylated anti-TNFα biologic approved for the treatment of rheumatoid arthritis and Crohn disease. The product, developed by UCB, is a humanized antigen-binding fragment (Fab') of a monoclonal antibody that has been conjugated to polyethylene glycol. Certolizumab pegol was approved as a treatment for rheumatoid arthritis in the EU, US and Canada in 2009, and as a treatment for Crohn disease in Switzerland in 2007 and the US in 2008. Certolizumab pegol is entering into an increasingly competitive marketplace, especially in rheumatoid arthritis, but clinical data demonstrate benefits across a range of clinical, radiographic and patient reported outcomes.
journal_name
MAbsjournal_title
mAbsauthors
Goel N,Stephens Sdoi
10.4161/mabs.2.2.11271subject
Has Abstractpub_date
2010-03-01 00:00:00pages
137-47issue
2eissn
1942-0862issn
1942-0870pii
11271journal_volume
2pub_type
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