Abstract:
:Monoclonal antibodies are used with great success in many different therapeutic domains. In order to satisfy the growing demand and to lower the production cost of these molecules, many alternative systems have been explored. Among them, the baculovirus/insect cells system is a good candidate. This system is very safe, given that the baculoviruses have a highly restricted host range and they are not pathogenic to vertebrates or plants. But the major asset is the speed with which it is possible to obtain very stable recombinant viruses capable of producing fully active proteins whose glycosylation pattern can be modulated to make it similar to the human one. These features could ultimately make the difference by enabling the production of antibodies with very low costs. However, efforts are still needed, in particular to increase production rates and thus make this system commercially viable for the production of these therapeutic agents.
journal_name
MAbsjournal_title
mAbsauthors
Cérutti M,Golay Jdoi
10.4161/mabs.19942subject
Has Abstractpub_date
2012-05-01 00:00:00pages
294-309issue
3eissn
1942-0862issn
1942-0870pii
19942journal_volume
4pub_type
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