Abstract:
:Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most of the marketed antibodies are monospecific and therefore capable of interacting and interfering with a single target. However, complex diseases are often multifactorial in nature, and involve redundant or synergistic action of disease mediators or upregulation of different receptors, including crosstalk between their signaling networks. Consequently, blockade of multiple, different pathological factors and pathways may result in improved therapeutic efficacy. This result can be achieved by combining different drugs, or use of the dual targeting strategies applying bispecific antibodies that have emerged as an alternative to combination therapy. This review discusses the various dual targeting strategies for which bispecific antibodies have been developed and provides an overview of the established bispecific antibody formats.
journal_name
MAbsjournal_title
mAbsauthors
Kontermann REdoi
10.4161/mabs.4.2.19000subject
Has Abstractpub_date
2012-03-01 00:00:00pages
182-97issue
2eissn
1942-0862issn
1942-0870pii
19000journal_volume
4pub_type
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