Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice.

abstract：:Postmenopausal women on estrogen replacement therapy (ERT) have a reduced risk of developing colon cancer compared with postmenopausal women not on ERT, suggesting a role for estradiol (E2) in protection against this disease. To determine whether E2 protects against inflammation-associated colon cancer when administer...

journal_title：Endocrine-related cancer

authors： Armstrong CM,Billimek AR,Allred KF,Sturino JM,Weeks BR,Allred CD

更新日期：2013-06-27 00:00:00

abstract：:Calcitonin (CT) is a sensitive marker for medullary thyroid carcinoma. Normalization of early postoperative CT level is a favorable prognostic factor. The aim of this study was to establish the prognostic value of CT-level kinetics by preoperative tumor stage and postoperative elimination rate. Blood serum from 22 med...

journal_title：Endocrine-related cancer

authors： Ismailov SI,Piulatova NR

更新日期：2004-06-01 00:00:00

abstract：:Computed tomography (CT; unenhanced, followed by contrast-enhanced examinations) is the cornerstone of imaging of adrenal tumours. Attenuation values of <10 Hounsfield units on an unenhanced CT are practically diagnostic for adenomas. When lesions cannot be characterised adequately with CT, magnetic resonance imaging ...

journal_title：Endocrine-related cancer

authors： Ilias I,Sahdev A,Reznek RH,Grossman AB,Pacak K

更新日期：2007-09-01 00:00:00

abstract：:It has been proposed that knowledge of estrogen receptor beta (ER-beta) expression may refine estrogen receptor alpha (ER-alpha) predictivity of response to endocrine therapy. We challenged this hypothesis in ER-alpha-positive breast cancers subjected to preoperative antiestrogen treatment. Forty-seven elderly (> or =...

journal_title：Endocrine-related cancer

authors： Cappelletti V,Celio L,Bajetta E,Allevi A,Longarini R,Miodini P,Villa R,Fabbri A,Mariani L,Giovanazzi R,Galante E,Greco M,Grazia Daidone M

更新日期：2004-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma agonists have been proposed as breast cancer preventives. Individuals who carry a mutated copy of BRCA1, DNA repair-associated gene, are at increased risk for development of breast cancer. Published data in the field suggest there could be interactions between peroxisom...

journal_title：Endocrine-related cancer

authors： Furth PA

更新日期：2019-02-01 00:00:00

abstract：:The androgen receptor (AR) mediates the effects of male steroid hormones (androgens) and contributes to a wide variety of physiological and pathophysiological conditions. As such, the regulatory mechanisms governing AR activity are of high significance. Concerted effort has been placed on delineating the mechanisms th...

journal_title：Endocrine-related cancer

authors： Burd CJ,Morey LM,Knudsen KE

更新日期：2006-12-01 00:00:00

abstract：:Type 3 deiodinase (DIO3, D3) is reactivated in human neoplasias. Increased D3 levels in papillary thyroid carcinoma (PTC) have been associated with tumor size and metastatic disease. The objective of this study is to investigate the signaling pathways involved in DIO3 upregulation in PTC. Experiments were performed in...

journal_title：Endocrine-related cancer

authors： Romitti M,Wajner SM,Ceolin L,Ferreira CV,Ribeiro RV,Rohenkohl HC,Weber Sde S,Lopez PL,Fuziwara CS,Kimura ET,Maia AL

更新日期：2016-03-01 00:00:00

abstract：:We studied the psychological performance and the quality of life in patients with differentiated thyroid carcinoma, either during treatment with chronic suppressive doses of levothyroxine, or during the withdrawal of levothyroxine needed to perform whole-body scanning with radioactive iodine, with those of appropriate...

journal_title：Endocrine-related cancer

authors： Botella-Carretero JI,Galán JM,Caballero C,Sancho J,Escobar-Morreale HF

更新日期：2003-12-01 00:00:00

abstract：:Chitinase 3-like 1 (CHI3L1 or YKL40) is a secreted glycoprotein highly expressed in tumours from patients with advanced stage cancers, including prostate cancer (PCa). The exact function of YKL40 is poorly understood, but it has been shown to play an important role in promoting tumour angiogenesis and metastasis. The ...

journal_title：Endocrine-related cancer

authors： Jeet V,Tevz G,Lehman M,Hollier B,Nelson C

更新日期：2014-10-01 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours originating from neuroendocrine cells found throughout the body. Pancreatic NENs (PanNENs) are the second most common pancreatic malignancy accounting for 1-3% of all neoplasms developing in the pancreas. Despite having a low backgrou...

journal_title：Endocrine-related cancer

authors： Pipinikas CP,Berner AM,Sposito T,Thirlwell C

更新日期：2019-08-01 00:00:00

abstract：:The aim of this systematic review is to study the features of cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) by analysing the 129 documented cases in the English literature. The disease occurred almost exclusively in women. The median age of presentation for CMV-PTC was 24 years. Slightly over hal...

journal_title：Endocrine-related cancer

authors： Lam AK,Saremi N

更新日期：2017-04-01 00:00:00

abstract：:Obesity is becoming a global epidemic and is a risk factor for breast cancer. Environmental enrichment (EE), a model recapitulating an active lifestyle, leads to leanness, resistance to diet-induced obesity (DIO) and cancer. One mechanism is the activation of the hypothalamic-sympathoneural-adipocyte (HSA) axis. This ...

journal_title：Endocrine-related cancer

authors： Foglesong GD,Queen NJ,Huang W,Widstrom KJ,Cao L

更新日期：2019-05-01 00:00:00

abstract：:Thyroid cancer incidence is increasing all over the world - mostly due to an increase in the detection of small tumors that were previously undetected. A small percentage of these tumors lose the ability to uptake and/or to respond to radioiodine (RAI) therapy, especially in metastatic patients. There are several new ...

journal_title：Endocrine-related cancer

authors： Vaisman F,Carvalho DP,Vaisman M

更新日期：2015-12-01 00:00:00

abstract：:Insulinomas are rare endocrine neoplasias that constitute the most frequent islet cell tumours. Somatostatin (SST) analogs are tentatively used to inhibit insulin secretion and control tumour growth in patients with local invasion or inoperative metastasis, but variable responses have been reported. Data regarding som...

journal_title：Endocrine-related cancer

authors： de Sá SV,Corrêa-Giannella ML,Machado MC,de Souza JJ,Pereira MA,Patzina RA,Siqueira SA,Machado MC,Giannella-Neto D

更新日期：2006-03-01 00:00:00

abstract：:Although the authors of the present review have contributed to genetic discoveries in the field of pheochromocytoma research, we can legitimately ask whether these advances have led to improvements in the diagnosis and management of patients with pheochromocytoma. The answer to this question is an emphatic Yes! In the...

journal_title：Endocrine-related cancer

authors： Neumann HP,Young WF Jr,Krauss T,Bayley JP,Schiavi F,Opocher G,Boedeker CC,Tirosh A,Castinetti F,Ruf J,Beltsevich D,Walz M,Groeben HT,von Dobschuetz E,Gimm O,Wohllk N,Pfeifer M,Lourenço DM Jr,Peczkowska M,Patocs A,

更新日期：2018-08-01 00:00:00

abstract：:Mouse models of prostate cancer (PCa) are critical for understanding the biology of PCa initiation, progression, and treatment modalities. Here, we summarize recent advances in PCa mouse models that led to new insights into specific gene functions in PCa. For example, the study of transgenic mice with TMPRSS2/ERG, an ...

journal_title：Endocrine-related cancer

authors： Wu X,Gong S,Roy-Burman P,Lee P,Culig Z

更新日期：2013-06-24 00:00:00

abstract：:ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pretest risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Cente...

journal_title：Endocrine-related cancer

authors： Valderrabano P,Khazai L,Leon ME,Thompson ZJ,Ma Z,Chung CH,Hallanger-Johnson JE,Otto KJ,Rogers KD,Centeno BA,McIver B

更新日期：2017-03-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by dele...

journal_title：Endocrine-related cancer

authors： Harding B,Lemos MC,Reed AA,Walls GV,Jeyabalan J,Bowl MR,Tateossian H,Sullivan N,Hough T,Fraser WD,Ansorge O,Cheeseman MT,Thakker RV

更新日期：2009-12-01 00:00:00

abstract：:Carney triad (CT) is a rare condition with synchronous or metachronous occurrence of gastrointestinal stromal tumors (GISTs), paragangliomas (PGLs), and pulmonary chondromas in a patient. In contrast to Carney-Stratakis syndrome (CSS) and familial PGL syndromes, no germline or somatic mutations in the succinate dehydr...

journal_title：Endocrine-related cancer

authors： Haller F,Moskalev EA,Faucz FR,Barthelmeß S,Wiemann S,Bieg M,Assie G,Bertherat J,Schaefer IM,Otto C,Rattenberry E,Maher ER,Ströbel P,Werner M,Carney JA,Hartmann A,Stratakis CA,Agaimy A

更新日期：2014-08-01 00:00:00

abstract：:The function of estrogen receptor beta (ER-beta) in mammary tissue is not completely understood. While early observations were often conflicting, more recent data suggest an important role as a tumor-suppressor gene. A decrease of ER-beta expression has been observed in ductal carcinoma in situ and invasive carcinoma ...

journal_title：Endocrine-related cancer

authors： Rody A,Holtrich U,Solbach C,Kourtis K,von Minckwitz G,Engels K,Kissler S,Gätje R,Karn T,Kaufmann M

更新日期：2005-12-01 00:00:00

abstract：:The expression of estrogen receptor α (ERα) in breast cancer identifies patients most likely to respond to endocrine treatment. The second ER, ERβ, is also expressed in breast tumors, but its function and therapeutic potential need further study. Although in vitro studies have established that ERβ opposes transcriptio...

journal_title：Endocrine-related cancer

authors： Jonsson P,Katchy A,Williams C

更新日期：2014-01-30 00:00:00

abstract：:The protein MENIN is the product of the multiple endocrine neoplasia type I (MEN1) gene. Altered MENIN expression is one of the few events that are clearly associated with foregut neuroendocrine tumours (NETs), classical oncogenes or tumour suppressors being not involved. One of the current challenges is to understand...

journal_title：Endocrine-related cancer

authors： Hamze Z,Vercherat C,Bernigaud-Lacheretz A,Bazzi W,Bonnavion R,Lu J,Calender A,Pouponnot C,Bertolino P,Roche C,Stein R,Scoazec JY,Zhang CX,Cordier-Bussat M

更新日期：2013-10-24 00:00:00

abstract：:Chemotherapy remains the major treatment option for castration-resistant prostate cancer (CRPC) and limited cytotoxic options are available. Inherent chemotherapy resistance occurs in half of all patients and inevitably develops even in those who initially respond. Docetaxel has been the mainstay of therapy for 6 year...

journal_title：Endocrine-related cancer

authors： Mahon KL,Henshall SM,Sutherland RL,Horvath LG

更新日期：2011-07-04 00:00:00

abstract：:Neuroendocrine tumours (NET) of the gastroenteropancreatic system comprise a malignant entity with a low incidence. Only limited information is available on long-term clinical outcome and clinically applicable prognostic factors. We performed a retrospective analysis of a large, well-characterized centre-based patient...

journal_title：Endocrine-related cancer

authors： Pape UF,Berndt U,Müller-Nordhorn J,Böhmig M,Roll S,Koch M,Willich SN,Wiedenmann B

更新日期：2008-12-01 00:00:00

abstract：:Anaplastic thyroid cancer (ATC) is an aggressive malignancy with limited treatment options. We explored novel treatment modalities by targeting epigenetic modifications using inhibitors of BET (e.g. BRD4) activity. We evaluated the efficacy in the treatment of ATC of a novel BET inhibitor, PLX51107 (PLX), currently in...

journal_title：Endocrine-related cancer

authors： Zhu X,Park S,Lee WK,Cheng SY

更新日期：2019-09-01 00:00:00

abstract：:Medullary thyroid carcinomas (MTC) arise from thyroid parafollicular, calcitonin-producing C-cells and can occur either as sporadic or as hereditary diseases in the context of familial syndromes, including multiple endocrine neoplasia 2A (MEN2A), multiple endocrine neoplasia 2B (MEN2B) and familial MTC (FMTC). In a la...

journal_title：Endocrine-related cancer

authors： Castellone MD,Melillo RM

更新日期：2018-02-01 00:00:00

abstract：:Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health benefits including improved metabolism, cardioprotection, and cancer prevention. Much of the work on resveratrol and cancer comes from in vitro studies looking at resveratrol actions on cancer cells and pathways. There are, how...

journal_title：Endocrine-related cancer

authors： Carter LG,D'Orazio JA,Pearson KJ

更新日期：2014-05-06 00:00:00

abstract：:Pancreatic endocrine tumours (PETs) are rare and 'indolent' neoplasms that usually develop metastatic lesions and exhibit poor response to standard medical treatments. Few studies have investigated pathways responsible for PET cell growth and invasion and no alternative therapeutic strategies have been proposed. In a ...

journal_title：Endocrine-related cancer

authors： Di Florio A,Capurso G,Milione M,Panzuto F,Geremia R,Delle Fave G,Sette C

更新日期：2007-03-01 00:00:00

abstract：:Numerous epidemiological observations point to sex differences in lung cancer etiology and progression. The present study was aimed at understanding the bases of these sex differences. To test the effect of estradiol on tumor progression, we used a mouse model based on conditional Kras expression and concurrent deleti...

journal_title：Endocrine-related cancer

authors： Hammoud Z,Tan B,Badve S,Bigsby RM

更新日期：2008-06-01 00:00:00

abstract：:The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is a key signaling pathway that has been linked to both tumorigenesis and resistance to therapy in prostate cancer and other solid tumors. Given the significance of the PI3K/Akt/mTOR pathway in integrating cell survival signals a...

journal_title：Endocrine-related cancer

authors： Bitting RL,Armstrong AJ

更新日期：2013-05-20 00:00:00