Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer.

abstract：:The androgen receptor (AR) is well known to play a central role in the pathogenesis of prostate cancer (PCa). In several studies, AR was overexpressed in castration-resistant PCa (CRPC). However, the mechanism of AR overexpression in CRPC is not fully elucidated. Y-box binding protein-1 (YB-1) is a pleiotropic transcr...

journal_title：Endocrine-related cancer

authors： Shiota M,Takeuchi A,Song Y,Yokomizo A,Kashiwagi E,Uchiumi T,Kuroiwa K,Tatsugami K,Fujimoto N,Oda Y,Naito S

更新日期：2011-07-11 00:00:00

abstract：:Many clinicians prefer to avoid surgery in patients with carcinoid neoplasia, because of its slow growth and relatively favourable prognosis. Nevertheless, the commonest cause of death in patients with carcinoid is advanced metastatic disease, and both clinical and epidemiological data indicate that the more effective...

journal_title：Endocrine-related cancer

authors： Sutton R,Doran HE,Williams EM,Vora J,Vinjamuri S,Evans J,Campbell F,Raraty MG,Ghaneh P,Hartley M,Poston GJ,Neoptolemos JP

更新日期：2003-12-01 00:00:00

abstract：:Prostate cancer (PCa) and breast cancer (BCa) are both hormone-dependent cancers that require the androgen receptor (AR) and estrogen receptor (ER, ESR1) for growth and proliferation, respectively. Endocrine therapies that target these nuclear receptors (NRs) provide significant clinical benefit for metastatic patient...

journal_title：Endocrine-related cancer

authors： Blatt EB,Kopplin N,Kumar S,Mu P,Conzen SD,Raj GV

更新日期：2020-12-01 00:00:00

abstract：:The study aims to examine whether the annual variations in fasting plasma glucose (FPG) measurements, represented by the coefficient of variation (CV), predict cancer incidence and mortality in the subsequent years independent of traditional risk factors of type 2 diabetic patients. A computerized database of patients...

journal_title：Endocrine-related cancer

authors： Lin CC,Li CI,Liu CS,Lin WY,Chen CC,Yang SY,Lee CC,Li TC

更新日期：2012-07-18 00:00:00

abstract：:The number of individuals who succumb to thyroid cancer has been increasing and those who are refractory to standard care have limited therapeutic options, highlighting the importance of developing new treatments for patients with aggressive forms of the disease. Mutational activation of MAPK signaling, through BRAF a...

journal_title：Endocrine-related cancer

authors： Knippler CM,Saji M,Rajan N,Porter K,La Perle KMD,Ringel MD

更新日期：2019-08-01 00:00:00

abstract：:Obesity increases both the risk and mortality associated with many types of cancer including that of the breast. In mice, obesity increases both incidence of spontaneous tumors and burden of transplanted tumors. Our findings identify leptin, an adipose secreted cytokine, in promoting increased mammary tumor burden in ...

journal_title：Endocrine-related cancer

authors： Zheng Q,Dunlap SM,Zhu J,Downs-Kelly E,Rich J,Hursting SD,Berger NA,Reizes O

更新日期：2011-07-11 00:00:00

abstract：:Certain members of the thiazolidinedione (TZD) family of the peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as troglitazone and ciglitazone, exhibit antitumor activities; however, the underlying mechanism remains inconclusive. Substantial evidence suggests that the antiproliferative effect...

journal_title：Endocrine-related cancer

authors： Weng JR,Chen CY,Pinzone JJ,Ringel MD,Chen CS

更新日期：2006-06-01 00:00:00

abstract：:Small-intestinal carcinoids (SIC) are the most common small-bowel malignancies. We sought to determine the risk of developing SIC before and after other primary malignancies (PM) and the prognosis of patients with SIC, with and without another PM. We used the Surveillance, Epidemiology, and End Results database to ide...

journal_title：Endocrine-related cancer

authors： Amin S,Warner RR,Itzkowitz SH,Kim MK

更新日期：2012-05-24 00:00:00

abstract：:Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours originating from neuroendocrine cells found throughout the body. Pancreatic NENs (PanNENs) are the second most common pancreatic malignancy accounting for 1-3% of all neoplasms developing in the pancreas. Despite having a low backgrou...

journal_title：Endocrine-related cancer

authors： Pipinikas CP,Berner AM,Sposito T,Thirlwell C

更新日期：2019-08-01 00:00:00

abstract：:Approximately 80% of human ovarian and endometrial cancers and 50% of breast cancers express GnRH and its receptor as part of an autocrine regulatory system. After binding of its ligand the tumor GnRH receptor couples to G-protein alphai and activates a variety of intracellular signaling mechanisms. (1) Through activa...

journal_title：Endocrine-related cancer

authors： Emons G,Gründker C,Günthert AR,Westphalen S,Kavanagh J,Verschraegen C

更新日期：2003-06-01 00:00:00

abstract：:To analyze the genetic alterations of pheochromocytomas and evaluate the difference among malignant, extra-adrenal, and benign pheochromocytomas. Forty-three tumor samples were tested for genetic changes using multiplex ligation-dependent probe amplification. Among them, 39 samples were available for protein expressio...

journal_title：Endocrine-related cancer

authors： Yuan W,Wang W,Cui B,Su T,Ge Y,Jiang L,Zhou W,Ning G

更新日期：2008-03-01 00:00:00

abstract：:The aim of this systematic review is to study the features of cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) by analysing the 129 documented cases in the English literature. The disease occurred almost exclusively in women. The median age of presentation for CMV-PTC was 24 years. Slightly over hal...

journal_title：Endocrine-related cancer

authors： Lam AK,Saremi N

更新日期：2017-04-01 00:00:00

abstract：:Prostate cancer is the most common cancer in men, resulting in over 10 000 deaths/year in the UK. Sequencing and copy number analysis of primary tumours has revealed heterogeneity within tumours and an absence of recurrent founder mutations, consistent with non-genetic disease initiating events. Using methylation prof...

journal_title：Endocrine-related cancer

authors： Massie CE,Spiteri I,Ross-Adams H,Luxton H,Kay J,Whitaker HC,Dunning MJ,Lamb AD,Ramos-Montoya A,Brewer DS,Cooper CS,Eeles R,UK Prostate ICGC Group.,Warren AY,Tavaré S,Neal DE,Lynch AG

更新日期：2015-04-01 00:00:00

abstract：:Selection of novel molecular markers is an important goal of cancer genomics studies. The aim of our analysis was to apply the multivariate bioinformatical tools to rank the genes - potential markers of papillary thyroid cancer (PTC) according to their diagnostic usefulness. We also assessed the accuracy of benign/mal...

journal_title：Endocrine-related cancer

authors： Fujarewicz K,Jarzab M,Eszlinger M,Krohn K,Paschke R,Oczko-Wojciechowska M,Wiench M,Kukulska A,Jarzab B,Swierniak A

更新日期：2007-09-01 00:00:00

abstract：:Combined clinical and laboratory investigations of multiple endocrine neoplasia type 1 (MEN1) have resulted in an increased understanding of this disorder which may be inherited as an autosomal dominant condition. Defining the features of each disease manifestation in MEN1 has improved patient management and treatment...

journal_title：Endocrine-related cancer

authors： Pannett AA,Thakker RV

更新日期：1999-12-01 00:00:00

abstract：:There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model to investigate how NETs develop and the underlying mechanisms. Menin, encoded by the MEN1 gene, at least partly acts as a scaffold protein by intera...

journal_title：Endocrine-related cancer

authors： Feng Z,Ma J,Hua X

更新日期：2017-10-01 00:00:00

abstract：:The potential of aromatase (estrogen synthetase) within the breast to provide a significant source of estrogen mediating tumor proliferation is suggested by studies reporting 4- to 6-fold higher estrogen levels in tumors than in plasma of postmenopausal patients with breast cancer. Recent studies in our laboratory hav...

journal_title：Endocrine-related cancer

authors： Brodie A,Lu Q,Liu Y,Long B

更新日期：1999-06-01 00:00:00

abstract：:Insulinomas are rare endocrine neoplasias that constitute the most frequent islet cell tumours. Somatostatin (SST) analogs are tentatively used to inhibit insulin secretion and control tumour growth in patients with local invasion or inoperative metastasis, but variable responses have been reported. Data regarding som...

journal_title：Endocrine-related cancer

authors： de Sá SV,Corrêa-Giannella ML,Machado MC,de Souza JJ,Pereira MA,Patzina RA,Siqueira SA,Machado MC,Giannella-Neto D

更新日期：2006-03-01 00:00:00

abstract：:The aim of this randomized multicenter phase III trial was to compare chemotherapy and interferon (IFN) in patients with metastatic carcinoid tumors. Patients with documented progressive, unresectable, metastatic carcinoid tumors were randomized between 5-fluorouracil plus streptozotocin (day 1-5) and recombinant IFN-...

journal_title：Endocrine-related cancer

authors： Dahan L,Bonnetain F,Rougier P,Raoul JL,Gamelin E,Etienne PL,Cadiot G,Mitry E,Smith D,Cvitkovic F,Coudert B,Ricard F,Bedenne L,Seitz JF,Fédération Francophone de Cancérologie Digestive (FFCD).,Digestive Tumors Group of the F

更新日期：2009-12-01 00:00:00

abstract：:The HIV protease inhibitor Nelfinavir (NFV) inhibits PI3K/AKT and MAPK/ERK signaling pathways, emerging targets in thyroid cancers. We examined the effects of NFV on cancer cells that derived from follicular (FTC), papillary (PTC) and anaplastic (ATC) thyroid cancers. NFV (1-20 µM) was tested in FTC133, BCPAP and SW17...

journal_title：Endocrine-related cancer

authors： Jensen K,Bikas A,Patel A,Kushchayeva Y,Costello J,McDaniel D,Burman K,Vasko V

更新日期：2017-03-01 00:00:00

abstract：:The genetics behind predisposition to small intestinal neuroendocrine tumors (SI-NETs) is largely unknown, but there is growing awareness of a familial form of the disease. We aimed to identify germline mutations involved in the carcinogenesis of SI-NETs. The strategy included next-generation sequencing of exome- and/...

journal_title：Endocrine-related cancer

authors： Dumanski JP,Rasi C,Björklund P,Davies H,Ali AS,Grönberg M,Welin S,Sorbye H,Grønbæk H,Cunningham JL,Forsberg LA,Lind L,Ingelsson E,Stålberg P,Hellman P,Tiensuu Janson E

更新日期：2017-08-01 00:00:00

abstract：:It has been proposed that knowledge of estrogen receptor beta (ER-beta) expression may refine estrogen receptor alpha (ER-alpha) predictivity of response to endocrine therapy. We challenged this hypothesis in ER-alpha-positive breast cancers subjected to preoperative antiestrogen treatment. Forty-seven elderly (> or =...

journal_title：Endocrine-related cancer

authors： Cappelletti V,Celio L,Bajetta E,Allevi A,Longarini R,Miodini P,Villa R,Fabbri A,Mariani L,Giovanazzi R,Galante E,Greco M,Grazia Daidone M

更新日期：2004-12-01 00:00:00

abstract：:Bone metastases are common in advanced prostate cancer patients, but mechanisms by which specific pro-metastatic skeletal niches are formed before tumor cell homing are unclear. We aimed to analyze the effects of proteins secreted by primary prostate tumors on the bone microenvironment before the settlement and propag...

journal_title：Endocrine-related cancer

authors： Ardura JA,Álvarez-Carrión L,Gutiérrez-Rojas I,Friedman PA,Gortázar AR,Alonso V

更新日期：2020-07-01 00:00:00

abstract：:Several lines of evidence indicate that tumorigenesis is a complex multistep process, and that most, if not all, cancers acquire the same set of functional capabilities during development and progression, albeit through various mechanistic strategies. Increasing data show an important role of microRNAs (miRNAs or miRs...

journal_title：Endocrine-related cancer

authors： Santarpia L,Nicoloso M,Calin GA

更新日期：2010-01-29 00:00:00

abstract：:Ovarian cancer remains one of the leading causes of cancer deaths. Thus, new biomarkers predictive of response to the standard paclitaxel-carboplatin treatment are needed to improve chemotherapy strategies. MicroRNAs have the potential to modify drug outcomes. Based on this, we have demonstrated in this study that pat...

journal_title：Endocrine-related cancer

authors： Leskelä S,Leandro-García LJ,Mendiola M,Barriuso J,Inglada-Pérez L,Muñoz I,Martínez-Delgado B,Redondo A,de Santiago J,Robledo M,Hardisson D,Rodríguez-Antona C

更新日期：2010-12-21 00:00:00

abstract：:The cancer stem cell model proposes that tumors have a hierarchical organization in which tumorigenic cells give rise to non-tumorigenic cells, with only a subset of stem-like cells able to propagate the tumor. In the case of prostate cancer, recent analyses of genetically engineered mouse (GEM) models have provided e...

journal_title：Endocrine-related cancer

authors： Shibata M,Shen MM

更新日期：2015-12-01 00:00:00

abstract：:The realization that microRNAs (miRNAs) are frequently deregulated in malignancy has had a major impact on cancer research. In particular, the recent finding that highly stable forms of miRNAs can be accurately measured in body fluids, including blood, has generated considerable excitement. Here, we discuss the potent...

journal_title：Endocrine-related cancer

authors： Selth LA,Tilley WD,Butler LM

更新日期：2012-06-18 00:00:00

abstract：:Prostate cancer development and progression is largely dependent on androgen receptor (AR) signaling. AR is a hormone-dependent transcription factor, which binds to thousands of sites throughout the human genome to regulate expression of directly responsive genes, including pro-survival genes that enable tumor cells t...

journal_title：Endocrine-related cancer

authors： Stelloo S,Linder S,Nevedomskaya E,Valle-Encinas E,de Rink I,Wessels LFA,van der Poel H,Bergman AM,Zwart W

更新日期：2020-02-01 00:00:00

abstract：:The endothelin system is a family of three similar small peptides, two G-protein-coupled receptors and two proteinases. Endothelins have several physiological roles, notably in embryonic differentiation and vascular homeostasis. Numerous types of tumour express endothelins and their regulation is often aberrant when c...

journal_title：Endocrine-related cancer

authors： Grimshaw MJ

更新日期：2007-06-01 00:00:00

abstract：:Previous SNP array analyses have revealed genomic alterations of the Notch pathway as being the most frequent abnormality in adrenocortical tumors (ACTs). The aim of the present study was to evaluate the expression of components of Notch signaling in ACTs and to correlate them with clinical outcome. The mRNA expressio...

journal_title：Endocrine-related cancer

authors： Ronchi CL,Sbiera S,Altieri B,Steinhauer S,Wild V,Bekteshi M,Kroiss M,Fassnacht M,Allolio B

更新日期：2015-08-01 00:00:00