Peroxisome proliferator-activated receptor gamma and BRCA1.

Abstract:

:Peroxisome proliferator-activated receptor gamma agonists have been proposed as breast cancer preventives. Individuals who carry a mutated copy of BRCA1, DNA repair-associated gene, are at increased risk for development of breast cancer. Published data in the field suggest there could be interactions between peroxisome proliferator-activated receptor gamma and BRCA1 that could influence the activity of peroxisome proliferator-activated receptor gamma agonists for prevention. This review explores these possible interactions between peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma agonists and BRCA1 and discusses feasible experimental directions to provide more definitive information on the potential connections.

journal_name

Endocr Relat Cancer

journal_title

Endocrine-related cancer

authors

Furth PA

doi

10.1530/ERC-18-0449

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

R73-R79

issue

2

eissn

1351-0088

issn

1479-6821

pii

ERC-18-0449.R1

journal_volume

26

pub_type

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