Abstract:
:The most examined tumor markers in lung cancer patients are CEA, hormonal peptides, and some neurogenic enzymes in small cell carcinoma. Calcitonin, ACTH, ADH, CEA, neurophysin, oxytocin, beta-endorphin, neuron-specific enolase, and CK BB are elevated in serum specimens in 25-75% of cases of small cell carcinoma. The level of these markers is related to the stage of the disease in groups of patients; elevated pretreatment levels decrease with tumor regression. Marker levels are not valid in defining the tumor load and the presence of disease in the individual patient. It has not yet been documented that the markers can be used for clinical decisions on antineoplastic therapy. A recent development is the finding that measurement of CSF and plasma concentrations of ADH, calcitonin, CK BB, bombesin, and neuron-specific enolase may contribute in the diagnosis of CNS metastases including meningeal carcinomatosis.
journal_name
Chestjournal_title
Chestauthors
Hansen M,Pedersen AGdoi
10.1378/chest.89.4_supplement.219ssubject
Has Abstractpub_date
1986-04-01 00:00:00pages
219S-224Sissue
4 Suppleissn
0012-3692issn
1931-3543pii
S0012-3692(16)61952-9journal_volume
89pub_type
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