Tumor markers in patients with lung cancer.

Abstract:

:The most examined tumor markers in lung cancer patients are CEA, hormonal peptides, and some neurogenic enzymes in small cell carcinoma. Calcitonin, ACTH, ADH, CEA, neurophysin, oxytocin, beta-endorphin, neuron-specific enolase, and CK BB are elevated in serum specimens in 25-75% of cases of small cell carcinoma. The level of these markers is related to the stage of the disease in groups of patients; elevated pretreatment levels decrease with tumor regression. Marker levels are not valid in defining the tumor load and the presence of disease in the individual patient. It has not yet been documented that the markers can be used for clinical decisions on antineoplastic therapy. A recent development is the finding that measurement of CSF and plasma concentrations of ADH, calcitonin, CK BB, bombesin, and neuron-specific enolase may contribute in the diagnosis of CNS metastases including meningeal carcinomatosis.

journal_name

Chest

journal_title

Chest

authors

Hansen M,Pedersen AG

doi

10.1378/chest.89.4_supplement.219s

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

219S-224S

issue

4 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)61952-9

journal_volume

89

pub_type

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