Abstract:
:The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(II). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction.
journal_name
Mol Biosystjournal_title
Molecular bioSystemsauthors
Besold AN,Amick DL,Michel SLdoi
10.1039/c4mb00246fsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
1753-6issue
7eissn
1742-206Xissn
1742-2051journal_volume
10pub_type
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