Abstract:
:We report the discovery of benzoxaborole antitrypanosomal agents and their structure-activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC50 values as low as 0.02 μg/mL and in vivo efficacy in acute murine infection models against Tryapnosoma brucei.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Ding D,Zhao Y,Meng Q,Xie D,Nare B,Chen D,Bacchi CJ,Yarlett N,Zhang YK,Hernandez V,Xia Y,Freund Y,Abdulla M,Ang KH,Ratnam J,McKerrow JH,Jacobs RT,Zhou H,Plattner JJdoi
10.1021/ml100013ssubject
Has Abstractpub_date
2010-04-06 00:00:00pages
165-9issue
4issn
1948-5875journal_volume
1pub_type
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