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Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry.

Abstract：

:An active site mapping of human cathepsin B with dipeptide nitrile inhibitors was performed for a combinatorial approach by introducing several points of diversity and stepwise optimizing the inhibitor structure. To address the occluding loop of cathepsin B by a carboxylate moiety, click chemistry to generate linker-connected molecules was applied. Inhibitor 17 exhibited K i values of 41.3 nM, 27.3 nM, or 19.2 nM, depending on the substrate and pH of the assay. Kinetic data were discussed with respect to the conformational selection and induced fit models.

journal_name

ACS Med Chem Lett

journal_title

ACS medicinal chemistry letters

authors

Schmitz J,Li T,Bartz U,Gütschow M

doi

10.1021/acsmedchemlett.5b00474

subject

Has Abstract

pub_date

2015-12-28 00:00:00

pages

211-6

issue

3

issn

1948-5875

journal_volume

7

pub_type

杂志文章

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