Abstract:
:Selective activation of the M1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Kuduk SD,Chang RK,Greshock TJ,Ray WJ,Ma L,Wittmann M,Seager MA,Koeplinger KA,Thompson CD,Hartman GD,Bilodeau MTdoi
10.1021/ml300280gsubject
Has Abstractpub_date
2012-10-13 00:00:00pages
1070-4issue
12issn
1948-5875journal_volume
3pub_type
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journal_title:ACS medicinal chemistry letters
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