Abstract:
:Acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. It is an important target for both therapeutic drugs that treat Alzheimer's disease and chemical warfare agents that cripple the nervous system and cause death through paralysis. The enzyme has both catalytic and peripheral sites to which inhibitors may bind. Structures of recombinant human acetylcholinesterase in complex with the natural product inhibitors dihydrotanshinone I and territrem B reveal dihydrotanshinone I binding that is specific to only the peripheral site and territrem B binding that spans both sites and distorts the protein backbone in the peripheral site. These inhibitors may function as important molecular templates for therapeutics used for treatment of disease and protection against nerve agents.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Cheung J,Gary EN,Shiomi K,Rosenberry TLdoi
10.1021/ml400304wsubject
Has Abstractpub_date
2013-09-23 00:00:00pages
1091-6issue
11issn
1948-5875journal_volume
4pub_type
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