Abstract:
:A novel modulator of sodium ion currents was synthesized in 6 steps from a protected dihydroxypyrrolidine nitrone, via 1,3-dipolar cycloaddition reaction with acrylamide. Sodium ion currents in B50 cells were evaluated in comparison to saxitoxin and tetrodotoxin, and revealed an IC(50) of 15.7 muM. The new compound shows no evidence of binding to the C-lobe of the saxitoxin-binding protein saxiphilin.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Mao H,Fieber LA,Gawley REdoi
10.1021/ml100035tsubject
Has Abstractpub_date
2010-03-31 00:00:00pages
135-138issue
3issn
1948-5875journal_volume
1pub_type
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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