Abstract:
:We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Hu Y,Amin MN,Padhee S,Wang RE,Qiao Q,Bai G,Li Y,Mathew A,Cao C,Cai Jdoi
10.1021/ml3001215subject
Has Abstractpub_date
2012-07-12 00:00:00pages
683-6issue
8issn
1948-5875journal_volume
3pub_type
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