Abstract:
:The multistep preparation of (11)C-levetiracetam ((11)C-LEV) was carried out by a one-pot radiosynthesis with 8.3 ± 1.6% (n = 8) radiochemical yield in 50 ± 5.0 min. Briefly, the propionaldehyde was converted to propan-1-imine in situ as labeling precursor by incubation with ammonia. Without further separation, the imine was reacted with (11)C-HCN to form (11)C-aminonitrile. This crude was then reacted with 4-chlorobutyryl chloride and followed by hydrolysis to yield (11)C-LEV after purification by chiral high-performance liquid chromatography (HPLC). Both the radiochemical and enantiomeric purities of (11)C-LEV were >98%.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Cai H,Mangner TJ,Muzik O,Wang MW,Chugani DC,Chugani HTdoi
10.1021/ml500285tsubject
Has Abstractpub_date
2014-08-19 00:00:00pages
1152-5issue
10issn
1948-5875journal_volume
5pub_type
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