Abstract:
:Two novel benzofuran derivatives coupled with (99m)Tc complexes were tested as probes for imaging cerebral β-amyloid plaques using single photon emission tomography. Although both derivatives bound to Aβ(1-42) aggregates, (99m)Tc-BAT-BF showed higher affinity than (99m)Tc-MAMA-BF. In sections of brain tissue from an animal model of AD, (99m)Tc-BAT-BF clearly labeled β-amyloid plaques. In biodistribution experiments using normal mice, (99m)Tc-BAT-BF displayed high uptake soon after its injection and washed out from the brain rapidly, a highly desirable feature for an imaging agent. (99m)Tc-BAT-BF may be a potential probe for imaging β-amyloid plaques in Alzheimer's brains.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Ono M,Fuchi Y,Fuchigami T,Kobashi N,Kimura H,Haratake M,Saji H,Nakayama Mdoi
10.1021/ml100140dsubject
Has Abstractpub_date
2010-08-02 00:00:00pages
443-7issue
8issn
1948-5875journal_volume
1pub_type
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