Abstract:
:A new subseries of ROMK inhibitors exemplified by 28 has been developed from the initial screening hit 1. The excellent selectivity for ROMK inhibition over related ion channels and pharmacokinetic properties across preclinical species support further preclinical evaluation of 28 as a new mechanism diuretic. Robust pharmacodynamic effects in both SD rats and dogs have been demonstrated.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Walsh SP,Shahripour A,Tang H,Teumelsan N,Frie J,Zhu Y,Priest BT,Swensen AM,Liu J,Margulis M,Visconti R,Weinglass A,Felix JP,Brochu RM,Bailey T,Thomas-Fowlkes B,Alonso-Galicia M,Zhou X,Pai LY,Corona A,Hampton C,Hdoi
10.1021/ml500440usubject
Has Abstractpub_date
2015-05-07 00:00:00pages
747-52issue
7issn
1948-5875journal_volume
6pub_type
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