Abstract:
:The influence of ionization states of hydroxamates and retrohydroxamates and the presence of zinc ions in the active site were investigated using the wild-type and E402Q mutant of MMP-9. The deprotonated hydroxamates showed a significantly enhanced enrichment factor in the presence of zinc ions. A pharmacophore model was developed based on the deprotonated compounds and was used to identify four structurally diverse compounds with antiproliferative activities.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Zhong H,Wees MA,Faure TD,Carrillo C,Arbiser J,Bowen JPdoi
10.1021/ml200031msubject
Has Abstractpub_date
2011-03-29 00:00:00pages
455-60issue
6issn
1948-5875journal_volume
2pub_type
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