Abstract:
:Carbazoles represent a family of tricyclic compounds that widely appeared in nature. Numerous studies have revealed a diverse array of bioactivity associated with this scaffold. In the present study, a novel and highly efficient methodology for preparing 1,3-dihydroxy-2-carboxycarbazole from indole-3-acetic acid and Meldrum's acid was developed. Furthermore, biological characterization demonstrated that this multisubstituted carbazole analogue exhibited inhibitory activity on Aβ aggregation, antioxidative properties, and promising neuroprotective activities in a cellular model of Alzheimer's disease, thus further supporting the valuable application of this synthetic methodology in search for effective neuroprotectants.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Liu K,Zhang Sdoi
10.1021/acsmedchemlett.5b00158subject
Has Abstractpub_date
2015-07-10 00:00:00pages
894-7issue
8issn
1948-5875journal_volume
6pub_type
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