Abstract:
:Protein kinases are key regulators that govern complex cellular processes. Dysregulation of kinase signaling is associated in many human diseases, particularly cancers and developmental and metabolic disorders. Tyrosine kinase inhibitors have achieved great success in molecular targeted therapies for cancer and now is expanding to other therapeutic areas. The onset of drug resistance to prolonged TKI treatment brings new challenges in TKI drug development. The deep understanding of disease pathologies related to TKs and drug resistance mechanisms will generate new waves for seeking highly selective, potent, and safe TKIs.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Cui JJdoi
10.1021/ml500091psubject
Has Abstractpub_date
2014-03-06 00:00:00pages
272-4issue
4issn
1948-5875journal_volume
5pub_type
杂志文章abstract::The National Institutes of Health (NIH) closure of the agency's Center for Regenerative Medicine (CRM), which focused on therapeutic development of induced pluripotent stem cells (iPS), was caused by the lack of progress in practical development of the iPSs for use in human therapies. As the NIH evaluates priorities i...
journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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更新日期:2014-10-08 00:00:00
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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更新日期:2013-06-24 00:00:00
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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更新日期:2018-08-01 00:00:00
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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更新日期:2010-04-06 00:00:00
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
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journal_title:ACS medicinal chemistry letters
pub_type: 已发布勘误
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更新日期:2020-06-24 00:00:00
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journal_title:ACS medicinal chemistry letters
pub_type: 杂志文章
doi:10.1021/acsmedchemlett.7b00264
更新日期:2017-09-13 00:00:00