Abstract:
:We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro potency, improving the pharmacokinetic (PK) profile, and increasing in vivo efficacy in rodent inflammatory and neuropathic pain assays.
journal_name
ACS Med Chem Lettjournal_title
ACS medicinal chemistry lettersauthors
Chobanian HR,Guo Y,Liu P,Chioda MD,Fung S,Lanza TJ,Chang L,Bakshi RK,Dellureficio JP,Hong Q,McLaughlin M,Belyk KM,Krska SW,Makarewicz AK,Martel EJ,Leone JF,Frey L,Karanam B,Madeira M,Alvaro R,Shuman J,Salituro Gdoi
10.1021/ml5001239subject
Has Abstractpub_date
2014-04-10 00:00:00pages
717-21issue
6issn
1948-5875journal_volume
5pub_type
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journal_title:ACS medicinal chemistry letters
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