Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania.

Abstract:

:The effects of infection of mice with Leishmania major on liver microsomal protein and cytochrome P-450 were examined. The levels of hepatic microsomal protein and cytochrome P-450 were monitored at 6, 7, 9 and 12 weeks post-infection. The results indicated that the amount of hepatic microsomal protein and cytochrome P-450 were unchanged throughout the course of infection with L. major, despite the high degree of parasite proliferation in Kupffer cells and marked reduction in phagocytosis. The current results clearly indicate that Leishmania-induced macrophage suppression has no inhibitory effect on hepatic microsomal protein and cytochrome P-450.

authors

al-Mofleh IA,al-Khuwaitir SA,Mahmoud AA,Kyegombe DB,al-Tuwaijri AS

doi

10.1111/j.1440-1746.1989.tb00855.x

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

513-9

issue

6

eissn

0815-9319

issn

1440-1746

journal_volume

4

pub_type

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