Effectiveness of Multistrain Versus Single-strain Probiotics: Current Status and Recommendations for the Future.


:Probiotics are investigated as single-strain and multistrain products. In the market, however, there is an increasing tendency to work with multistrain probiotics, in particular, products with a high number of different strains. There are some thoughts behind this: more strains imply more chances of success; it can mean a broader spectrum of efficacy, and there is often the hope that there are at least additive and, potentially, even synergistic effects. The present review did not find convincing evidence that these assumptions are valid. There is, however, also no strong evidence that the assumptions are incorrect and/or that there is antagonistic activity between strains in a combination. We suggest that, to answer these questions, structured research is conducted. Starting with a systematic review of meta-analyses that have compared single-strain and multistrain probiotic efficacy, dedicated human studies need to be performed, comparing single-strain and multistrain probiotics to each other and placebo. In vitro and animal studies can provide indications and may help understand mechanisms. For human, animal, and in vitro studies, it is recommended to work with the simple setup of 2 single strains, a 2-strain combination, and placebo. It is also important in such research to take into consideration the doses, as a combination product will have a higher total dose.


J Clin Gastroenterol


Ouwehand AC,Invernici MM,Furlaneto FAC,Messora MR




Has Abstract


2018-11-01 00:00:00








52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017


  • Fermentation in the human large intestine: its physiologic consequences and the potential contribution of prebiotics.

    abstract::The human large intestine harbors a complex microbiota containing many hundreds of different bacterial species. Although structure/function relationships between different components of the microbiota are unclear, this complex multicellular entity plays an important role in maintaining homeostasis in the body. Many of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Macfarlane GT,Macfarlane S

    更新日期:2011-11-01 00:00:00

  • Review of musculoskeletal injuries and prevention in the endoscopy practitioner.

    abstract::Practitioners of endoscopy often experience musculoskeletal pain and injury (most often in the back, neck, shoulders, hands, wrists, and thumbs) that are associated with the minute and repetitive strain that is placed on these areas during endoscopic procedures. This review of the current documentation of endoscopy-re...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Harvin G

    更新日期:2014-08-01 00:00:00

  • High frequency of genotype D and spontaneous hepatitis B virus genomic mutations among Haitians in a multiethnic North American population.

    abstract:GOALS/BACKGROUND:The importance of hepatitis B virus (HBV) genotype and mutations has been increasingly recognized. We aimed to determine HBV genotype, precore (PC), and basal core promoter region (BCP) mutations in a HBV multiethnic South Florida population. STUDY:Samples from 213 patients were tested for HBV-DNA usi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Couto CA,Levy C,Morris CJ,Hill M,de Medina M,Sanborn MR,Cloherty GA,Schiff ER,Martin P

    更新日期:2013-01-01 00:00:00

  • Resolution of hereditary hemorrhagic telangiectasia and anemia with prolonged alpha-interferon therapy for chronic hepatitis C.

    abstract::Hereditary hemorrhagic telangiectasia is a group of autosomal dominant disorders, characterized by telangiectases that develop in the skin, mucous membranes, and visceral organs. Currently, there is no satisfactory treatment of hereditary hemorrhagic telangiectasia. Interferon has never been used for the treatment of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Massoud OI,Youssef WI,Mullen KD

    更新日期:2004-04-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • The Psychobiological Etiology of Gastrointestinal Distress in Sport: A Review.

    abstract::Gastrointestinal (GI) disturbances are common during training and competition, especially among endurance athletes. Historically, little attention has been paid to the psychobiological etiology of GI problems in sport. The aim of this review is to: (1) provide a physiological overview of how psychological stress and a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Wilson PB

    更新日期:2020-04-01 00:00:00

  • Clinical Implications of Histologic Abnormalities in Ileocolonic Biopsies of Patients With Crohn's Disease in Remission.

    abstract:BACKGROUND:For patients with Crohn's disease (CD) who have colonoscopy during periods of clinical remission, the utility of taking ileocolonic biopsy specimens to assess disease activity is disputed. GOALS:We explored the clinical implications of histologic disease activity in such patients. STUDY:We reviewed medical...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Brennan GT,Melton SD,Spechler SJ,Feagins LA

    更新日期:2017-01-01 00:00:00

  • A survey of hepatitis C treatment clinical practice patterns using the newly approved protease inhibitors.

    abstract:GOALS:To describe current hepatitis C virus (HCV) treatment practices in the United States and identify physician characteristics associated with the use of first generation direct-acting antivirals (DAAs). BACKGROUND:HCV treatment practice patterns have not been assessed after the introduction of DAA, which are now c...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Chen EY,Lee WM,Hynan LS,Singal AG

    更新日期:2013-10-01 00:00:00

  • Esophageal Function Abnormalities in Patients With Barrett's Esophagus.

    abstract::Various esophageal functional abnormalities have been described in patients with Barrett's esophagus (BE). A significantly higher esophageal acid exposure especially in the supine position has been documented in BE, as compared with the other gastroesophageal reflux disease phenotypes. In addition, weakly acidic reflu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Fass R,Teramoto O,Kurin M,Khalessi A,Kitayama Y,Shibli F

    更新日期:2020-07-01 00:00:00

  • Leiomyosarcoma of the duodenum recognized preoperatively.

    abstract::We report the preoperative histologic diagnosis of leiomyosarcoma of the duodenum and review the clinical aspects and treatment of this tumor. The endoscopic techniques were critical in obtaining the diagnosis and deciding the treatment plan. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Holst L,Burstein S,Morankar V,Goldberg M

    更新日期:1983-10-01 00:00:00

  • Subclinical Ascites Does Not Affect the Long-term Prognosis in Hepatitis B Virus-related Cirrhosis Patients Receiving Antivirals.

    abstract:BACKGROUND AND AIMS:This study evaluated the clinical significance of subclinical ascites in patients with hepatitis B virus-related cirrhosis treated with lamivudine (LMV) or entecavir (ETV). METHODS:This multicenter retrospective study involved 8 hospitals. Patients were classified by degree of ascites: (1) no ascit...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究


    authors: Yim SY,Lee JH,Ahn H,Kim SU,Kim SG,Kim YS,Kim JH,Choe WH,Kim TY,Jung YK,Suh SJ,Suk KT,An H,Yim HJ,Seo YS,Um SH

    更新日期:2016-09-01 00:00:00

  • Fibrinous pericarditis in alcoholic liver disease.

    abstract::The autopsy data at the University of Southern California Liver Unit was studied during a 6-year period to investigate the relationship of fibrinous pericarditis with liver diseases. We found 18 cases of fibrinous pericarditis in 220 patients with alcoholic liver disease but none in 32 patients with fulminant and suba...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yang SS,Kanel G

    更新日期:1989-02-01 00:00:00

  • New regulatory trends for probiotics.

    abstract::The aim of this paper (presented in Rome, Italy, at the 2nd Congress of Probiotics, Prebiotics, and New Food, September 7-9, 2003) was to provide an objective view of the regulatory trends at the European level specifically referring to probiotics, because until now they have never been directly mentioned nor official...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Prevot MB

    更新日期:2004-07-01 00:00:00

  • Acute pancreatitis induced by fluvastatin therapy.

    abstract::A 36-year-old male patient, after 3 months' treatment with fluvastatin 40 mg/d for hypercholesterolemia, presented with acute pancreatitis. The pancreatitis was mild, and the patient settled on medical treatment. Other causes of the disease were ruled out. Some months later, the patient reintroduced fluvastatin on his...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Tysk C,Al-Eryani AY,Shawabkeh AA

    更新日期:2002-11-01 00:00:00

  • Predictive Model for Neoplastic Potential of Gallbladder Polyp.

    abstract:GOAL:To provide the statistical predictive model for neoplastic potential of gallbladder polyp (GBP). BACKGROUND:Many studies have attempted to define the risk factors for neoplastic potential of GBP. It remains difficult to precisely adapt the reported risk factors for the decision of surgery. Estimating the probabil...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yang JI,Lee JK,Ahn DG,Park JK,Lee KH,Lee KT,Chi SA,Jung SH

    更新日期:2018-03-01 00:00:00

  • Ulcer healing after treatment with sucralfate emulsion or ranitidine. Randomized controlled study in peptic ulcer disease.

    abstract::A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lykkegaard Nielsen MC,Vagn Nielsen O,Moesgaard F

    更新日期:1988-08-01 00:00:00

  • Defining a clinically significant adverse impact of diagnosing Barrett's esophagus.

    abstract:BACKGROUND:Diagnosing a potentially life-threatening disease may adversely affect patient quality of life (QOL) independent of biologic effects. It is unknown whether the mere diagnosis of Barrett's esophagus (BE) adversely impacts patients' preferences (health-state utility) sufficiently to impair the cost-effectivene...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Rubenstein JH,Inadomi JM

    更新日期:2006-02-01 00:00:00

  • Comparison of Right Colon Adenoma Miss Rates Between Water Exchange and Carbon Dioxide Insufflation: A Prospective Randomized Controlled Trial.

    abstract:GOALS:To test the hypothesis that water exchange (WE), when compared with carbon dioxide (CO2) insufflation, significantly reduces the right colon adenoma miss rate (rAMR) in a blinded randomized controlled trial with cap-assisted colonoscopy. BACKGROUND:The unblinded consecutive group observational data showed that W...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Cheng CL,Kuo YL,Hsieh YH,Tang JH,Leung FW

    更新日期:2020-10-16 00:00:00

  • Campylobacter pylori. Diagnosis and treatment.

    abstract::There is now a plethora of methods to diagnose colonization of the human stomach with Campylobacter pylori, such as microbiological culture on various media, identification of C. pylori in biopsies or biopsy smears using various stains or neurological methods, serological demonstration of specific anti-C. pylori antib...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tytgat GN,Rauws EA,de Koster EH

    更新日期:1989-01-01 00:00:00

  • The effect of chronic aspirin use on duodenal and gastric ulcer hospitalizations.

    abstract::Aspirin is commonly accepted as a risk factor for gastric ulcer; however, there is little published evidence linking aspirin consumption to duodenal ulcer. The effect of 1 g of aspirin per day on site-specific ulcer hospitalizations was examined using data from a 3-year randomized, double-blind, placebo-controlled tri...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kurata JH,Abbey DE

    更新日期:1990-06-01 00:00:00

  • Glycosphingolipid composition of the gastric mucosa. A role of sulfatides in gastrointestinal mucosal defense?

    abstract::The glycosphingolipid (GSL) compositions of the human, rabbit, and rat gastric mucosa were studied and compared. In neutral GSLs, although GalCer was the most abundant component in every tissue examined, species-specific differences were clearly observed in their composition. Acidic GSLs were composed of sulfatides an...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Natomi H,Sugano K,Takaku F,Iwamori M

    更新日期:1990-01-01 00:00:00

  • A case of cyclosporine-sensitive, steroid-resistant, autoimmune chronic active hepatitis.

    abstract::Few alternative treatments are available for those patients with autoimmune chronic active hepatitis who fail to respond to the conventional treatment of corticosteroids. Such patients have a poor prognosis and frequently require liver transplantation. We report a patient with autoimmune hepatitis who failed treatment...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Person JL,McHutchison JG,Fong TL,Redeker AG

    更新日期:1993-12-01 00:00:00

  • Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rat.

    abstract::We sought to clarify the role of nitric oxide (NO) generated from inducible NO synthase (iNOS) during healing of rat gastric ulcers. After gastric ulcers were induced by acetic acid, rats were treated with vehicle, N(G)-nitro-L-arginine methyl ester (L-NAME), aminoguanidine (AG), and dexamethasone (Dex) by gastric int...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Akiba Y,Nakamura M,Mori M,Suzuki H,Oda M,Kimura H,Miura S,Tsuchiya M,Ishii H

    更新日期:1998-01-01 00:00:00

  • Duodenal polyps: diagnosis and management.

    abstract::Forty-five polyps were encountered at duodenoscopy between 1973 and 1978. Upper gastrointestinal x-rays were helpful in 25 patients, 13 of whom had duodenal polyps and 12 duodenal deformity or mass lesions. Polyps in 23 patients were larger than 1 cm in size. Biopsies were done in 38 patients; in 19 there was only nor...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Reddy RR,Schuman BM,Priest RJ

    更新日期:1981-06-01 00:00:00

  • In-practice predictors of response to proton pump inhibitor therapy in primary care patients with dyspepsia in an Asian population.

    abstract:BACKGROUND:Data on Asian patients who present to primary care physicians with dyspepsia are limited. AIM:To determine predictors of response to a trial of proton pump inhibitor therapy. METHOD:One hundred ninety patients presenting to their general practitioners with dyspeptic symptoms but without alarm symptoms, und...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Gwee KA,Hwang JE,Ho KY,Yeoh KG,Lum CF,Ang PK

    更新日期:2008-02-01 00:00:00

  • Treatment of benign chronic gastric ulcer with ranitidine. A randomized, double-blind, and placebo-controlled six week trial.

    abstract::A randomized, multicenter, double-blind, placebo-controlled study was conducted to determine whether ranitidine 150 mg b.i.d. for 6 weeks would expedite endoscopic healing or relief of symptoms in patients with benign gastric ulcer. Of 203 patients enrolled, 101 received ranitidine and 102 received placebo. Endoscopic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hirschowitz BI,DeLuca V,Graham D,Lorber S,Bright-Asare P,Katon R

    更新日期:1986-06-01 00:00:00

  • High Rates of Mortality in Geriatric Patients Admitted for Inflammatory Bowel Disease Management.

    abstract:GOAL:The goal of this study was to evaluate the inpatient mortality risk among geriatric patients with inflammatory bowel disease (IBD). BACKGROUND:The challenges of caring for elderly patients with IBD will increase with the aging of the US population. Given the complications of hospitalization, we set to examine if ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Schwartz J,Stein DJ,Lipcsey M,Li B,Feuerstein JD

    更新日期:2020-11-23 00:00:00

  • Constipation--a sign of a disease to be treated surgically, or a symptom to be deciphered as nonverbal communication?

    abstract::Constipation is not a sign but a symptom, which is not measurable scientifically. It has emotional components and must be dealt with in a holistic manner. The scientific approach aims only at the physiological derangement and serves to place the complaint in a more objective perspective. An algorithm can be constructe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,社论


    authors: Devroede G

    更新日期:1992-10-01 00:00:00

  • Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERD: A Double-Blind Randomized Trial.

    abstract:GOALS:To determine the proportion of patients with gastroesophageal reflux disease who are on proton pump inhibitors (PPIs) who could reduce their prior dosage by half, and identify predictors of successful step-down. BACKGROUND:Appropriate hypergastrinemia results from gastric acid inhibition. A gender difference in ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验


    authors: Helgadóttir H,Metz DC,Lund SH,Gizurarson S,Jacobsen EI,Asgeirsdóttir GA,Yngadóttir Y,Björnsson ES

    更新日期:2017-07-01 00:00:00

  • Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study.

    abstract::To investigate the influence of the brain-gut interactions on the pathophysiology of irritable bowel syndrome (IBS), we compared such patients (n = 10) with healthy control subjects (n = 11) by measuring the pressure of the colon and small intestine simultaneously with analysis of power spectrum of the electroencephal...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Fukudo S,Nomura T,Muranaka M,Taguchi F

    更新日期:1993-09-01 00:00:00