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Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis.

Abstract：

:Although the use of oral anticoagulants (vitamin K antagonists) has been abandoned in primary cardiovascular prevention due to lack of a favorable benefit-to-risk ratio, the indications for aspirin use in this setting continue to be a source of major debate, with major international guidelines providing conflicting recommendations. Here, we review the evidence in favor and against aspirin therapy in primary prevention based on the evidence accumulated so far, including recent data linking aspirin with cancer protection. While awaiting the results of several ongoing studies, we argue for a pragmatic approach to using low-dose aspirin in primary cardiovascular prevention and suggest its use in patients at high cardiovascular risk, defined as ≥2 major cardiovascular events (death, myocardial infarction, or stroke) projected per 100 person-years, who are not at increased risk of bleeding.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Halvorsen S,Andreotti F,ten Berg JM,Cattaneo M,Coccheri S,Marchioli R,Morais J,Verheugt FW,De Caterina R

doi

10.1016/j.jacc.2014.03.049

subject

Has Abstract

pub_date

2014-07-22 00:00:00

pages

319-27

issue

3

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(14)02579-0

journal_volume

64

pub_type

杂志文章,评审

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