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The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.

Abstract：

:Diabetes has emerged as a major threat to worldwide health. The increasing incidence of diabetes in young individuals is particularly worrisome given that the disease is likely to evolve over a period of years. In 1972, the existence of a diabetic cardiomyopathy was proposed based on the experience with four adult diabetic patients who suffered from congestive heart failure in the absence of discernible coronary artery disease, valvular or congenital heart disease, hypertension, or alcoholism. The exact mechanisms underlying the disease are unknown; however, an important component of the pathological alterations observed in these hearts includes the accumulation of extracellular matrix (ECM) proteins, in particular collagens. The excess deposition of ECM in the heart mirrors what occurs in other organs such as the kidney and peritoneum of diabetics. Mechanisms responsible for these alterations may include the excess production, reduced degradation, and/or chemical modification of ECM proteins. These effects may be the result of direct or indirect actions of high glucose concentrations. This article reviews our state of knowledge on the effects that diabetes-like conditions exert on the cells responsible for ECM production as well as relevant experimental and clinical data.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Asbun J,Villarreal FJ

doi

10.1016/j.jacc.2005.09.050

subject

Has Abstract

pub_date

2006-02-21 00:00:00

pages

693-700

issue

4

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(05)02747-6

journal_volume

47

pub_type

杂志文章,评审

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