Abstract:
:N-acetylprocainamide (NAPA) is said to have class III antiarrhythmic drug properties. The effects of NAPA (25 mg/kg intravenously) on sustained, stable, reentrant atrial flutter induced in 12 conscious dogs using a sterile pericarditis model were studied and compared with the effects of quinidine (5 mg/kg intravenously) given on a different day in 10 of the same 12 dogs. The effects of these drugs on atrial excitability, the atrial effective refractory period and intraatrial conduction time measured during rapid atrial pacing performed during sinus rhythm were also compared. The mean NAPA and quinidine serum levels were 17.7 and 7.1 micrograms/ml, respectively. Both NAPA and quinidine immediately prolonged the atrial flutter cycle length in all dogs, from 118 +/- 15 to 141 +/- 18 ms and from 119 +/- 17 to 153 +/- 21 ms, respectively (both p less than 0.001), and then terminated atrial flutter in 11 of the 12 NAPA studies and in 6 of the 10 quinidine studies. Neither drug affected atrial excitability. Both NAPA and quinidine increased the atrial effective refractory period significantly, from 138 +/- 17 to 168 +/- 20 ms (p less than 0.001) and from 136 +/- 14 to 148 +/- 16 ms (p less than 0.01), respectively. NAPA did not change intraatrial conduction time measured during atrial pacing at 150 beats/min, but during atrial pacing at 300 beats/min, it prolonged it from 51 +/- 9 to 54 +/- 10 ms (p less than 0.05), and at 400 beats/min, from 52 +/- 10 to 64 +/- 13 ms (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Okumura K,Waldo ALdoi
10.1016/s0735-1097(87)80474-6subject
Has Abstractpub_date
1987-06-01 00:00:00pages
1332-8issue
6eissn
0735-1097issn
1558-3597pii
S0735-1097(87)80474-6journal_volume
9pub_type
杂志文章abstract:OBJECTIVES:The study compared the influence of sympathetic stimulation on transmural and spatial dispersion of repolarization between LQT1 and LQT2 forms of congenital long QT sYndrome (LQTS). BACKGROUND:Cardiac events are more associated with sympathetic stimulation in LQT1 than in LQT2 or LQT3 syndrome. Experimental...
journal_title:Journal of the American College of Cardiology
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更新日期:2001-03-01 00:00:00
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更新日期:2002-07-17 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2017.12.054
更新日期:2018-03-06 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine whether contractile recovery induced by dobutamine in dysfunctioning viable myocardium supplied by nearly occluded vessels is related to an increase in blood flow in the absence of collaterals. BACKGROUND:Dobutamine is used to improve contractility in ventricular d...
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pub_type: 杂志文章,评审
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更新日期:2011-07-26 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-10-16 00:00:00
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更新日期:2004-03-17 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-08-01 00:00:00
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更新日期:1990-02-01 00:00:00
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更新日期:2001-09-01 00:00:00
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更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(91)90679-4
更新日期:1991-11-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jacc.2020.11.047
更新日期:2021-02-02 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2018.11.051
更新日期:2019-03-05 00:00:00
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更新日期:2010-04-20 00:00:00
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更新日期:2009-08-04 00:00:00
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更新日期:2002-02-20 00:00:00
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更新日期:2008-04-15 00:00:00
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更新日期:2006-12-05 00:00:00
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更新日期:2008-02-05 00:00:00
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更新日期:2011-07-19 00:00:00
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更新日期:1995-10-01 00:00:00
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更新日期:1997-03-15 00:00:00
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更新日期:1997-03-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2009.07.043
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to characterize the occurrence of phrenic nerve injury (PNI) and its outcome after radiofrequency (RF) ablation of atrial fibrillation (AF). BACKGROUND:It is recognized that extra-myocardial damage may develop owing to penetration of ablative energy. METHODS:Between 1997 and 2...
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pub_type: 杂志文章,多中心研究
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更新日期:2006-06-20 00:00:00
abstract:OBJECTIVES:This study sought to determine whether early disease is identifiable in asymptomatic relatives of patients with dilated cardiomyopathy (DCM) by means of noninvasive cardiologic assessment. BACKGROUND:DCM is diagnosed on the basis of advanced heart failure, where cardiac dilation and impaired contractility a...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(97)00433-6
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:We examined whether hydroxyfasudil, a specific Rho-kinase inhibitor, exerts cardioprotective effect on coronary ischemia/reperfusion (I/R) injury and, if so, whether nitric oxide (NO) is involved. BACKGROUND:Recent studies have demonstrated that Rho-kinase is substantially involved in the pathogenesis of ca...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2004.10.053
更新日期:2005-02-15 00:00:00