Studies on the mechanism by which tryptophan efflux from isolated synaptosomes is stimulated by depolarization.

abstract：:1. In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimenta...

journal_title：British journal of pharmacology

authors： Nakaya H,Takeda Y,Tohse N,Kanno M

更新日期：1991-05-01 00:00:00

abstract：:1. alpha 1-Adrenoceptor subtypes in rabbit thoracic aorta have been examined in binding and functional experiments. 2. [3H]-prazosin bound to two distinct populations of alpha 1-adrenoceptors (pKD,high = 9.94, Rhigh = 79.2 fmol mg-1 protein; pKD,low = 8.59, Rlow = 215 fmol mg-1 protein). Pretreatment with chloroethylc...

journal_title：British journal of pharmacology

authors： Oshita M,Kigoshi S,Muramatsu I

更新日期：1993-04-01 00:00:00

abstract：:Δ9 -tetrahydrocannabinol, the principal active component in Cannabis sativa extracts such as marijuana, participates in cell signalling by binding to cannabinoid CB1 and CB2 receptors on the cell surface. The CB1 receptors are present in both inhibitory and excitatory presynaptic terminals and the CB2 receptors are fo...

journal_title：British journal of pharmacology

authors： Basavarajappa BS,Joshi V,Shivakumar M,Subbanna S

更新日期：2019-09-01 00:00:00

abstract：:1. Repeated allergen challenge has been shown to increase the role of Rho-kinase in airway smooth muscle (ASM) contraction. We considered the possibility that active allergic sensitization by itself, that is, without subsequent allergen exposure, could be sufficient to enhance Rho-kinase-mediated ASM contraction. 2. G...

journal_title：British journal of pharmacology

authors： Schaafsma D,Gosens R,Bos IS,Meurs H,Zaagsma J,Nelemans SA

更新日期：2004-10-01 00:00:00

abstract：:1. Incubation of bovine adrenal chromaffin cells with veratridine (10-100 microM) during 24 h, caused a concentration-dependent release of the cytosolic lactate dehydrogenase (LDH) into the bathing medium, an indicator of cell death. Lubeluzole or its R(-) enantiomer, R91154, did not enhance LDH release. Both lubeluzo...

journal_title：British journal of pharmacology

authors： Cano-Abad MF,López MG,Hernández-Guijo JM,Zapater P,Gandía L,Sánchez-García P,García AG

更新日期：1998-07-01 00:00:00

abstract：:1 The vasopressor response to prostaglandin F2 alpha (PGF2 alpha) and to ((15S)-hydroxy-11 alpha, 9 alpha-(epoxymethano)-prosta-5Z, 13E-dienoic acid) (U-46619) in the canine isolated lung lobe was significantly attenuated following the administration of verapamil. 2 The pressor response to arachidonic acid (AA) was no...

journal_title：British journal of pharmacology

authors： Angerio AD,Fitzpatrick TM,Kot PA,Ramwell PW,Rose JC

更新日期：1981-05-01 00:00:00

abstract：:1. The functional role of the nitric oxide (NO)/guanosine 3':5'-cyclic monophosphate (cyclic GMP) pathway in experimental myocardial ischaemia and reperfusion was studied in rat isolated hearts. 2. Rat isolated hearts were perfused at constant pressure with Krebs-Henseleit buffer for 25 min (baseline), then made ischa...

journal_title：British journal of pharmacology

authors： du Toit EF,McCarthy J,Miyashiro J,Opie LH,Brunner F

更新日期：1998-03-01 00:00:00

abstract：:1. The mechanisms by which nicorandil causes relaxation of rat isolated small mesenteric arteries mounted on a Mulvany myograph was investigated by use of a combination of putatively mechanism-specific antagonists. 2. In arteries precontracted by the thromboxane-mimetic, U46619, the EC50 for cromakalim and levcromakal...

journal_title：British journal of pharmacology

authors： Fujiwara T,Angus JA

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cultured pre-adipocytes accumulate and metabolize zidovudine (ZDV), but its mode of accumulation into these cells is unclear. We investigated the mode of accumulation of [(3)H]-ZDV, and the impact of changes in external pH and modulators of drug transporters on its accumulation and metabolism. E...

journal_title：British journal of pharmacology

authors： Janneh O,Owen A,Bray PG,Back DJ,Pirmohamed M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure. We investigated the effects of cannabidiol, a non-psychoactive constituent of Cannabis sativa with anti-inflammatory properties that activates the 5-hydroxytryptamine receptor 5...

journal_title：British journal of pharmacology

authors： Avraham Y,Grigoriadis N,Poutahidis T,Vorobiev L,Magen I,Ilan Y,Mechoulam R,Berry E

更新日期：2011-04-01 00:00:00

abstract：:1. The effects of chronic dietary supplementation with omega 3 polyunsaturated fatty acids on endothelium-dependent relaxations were examined in isolated coronary microvessels of the pig. 2. Animals were maintained for four weeks with or without dietary supplementation of purified eicosapentaenoic acid (3.5 g daily) a...

journal_title：British journal of pharmacology

authors： Shimokawa H,Aarhus LL,Vanhoutte PM

更新日期：1988-12-01 00:00:00

abstract：:1. The effects of the glycine/NMDA receptor antagonist, (+)-HA-966 on the neurochemical and behavioural responses to amphetamine have been determined in the mouse and rat. 2. In vehicle-treated control mice, (+)-HA-966 (30-100 mg kg-1) did not affect dopamine synthesis in either the nucleus accumbens or striatum and w...

journal_title：British journal of pharmacology

authors： Hutson PH,Bristow LJ,Thorn L,Tricklebank MD

更新日期：1991-08-01 00:00:00

abstract：:1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induce...

journal_title：British journal of pharmacology

authors： Mitchell HW

更新日期：1982-08-01 00:00:00

abstract：:1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches th...

journal_title：British journal of pharmacology

authors： Barth H,Lorenz W,Troidl H

更新日期：1975-11-01 00:00:00

abstract：:1. Ca2+ buffering function of sarcoplasmic reticulum (SR) in the resting state of arteries from spontaneously hypertensive rats (SHR) was examined. Differences in the effects of cyclopiazonic acid (CPA) and thapsigargin, agents which inhibit the Ca(2+)-ATPase of SR, on tension and cellular Ca2+ level were assessed in ...

journal_title：British journal of pharmacology

authors： Nomura Y,Asano M,Ito K,Uyama Y,Imaizumi Y,Watanabe M

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cytochrome P450 (CYP, P450) 3A4 is involved in the metabolism of 50% of drugs and its catalytic activity in vivo is not explained only by hepatic expression levels. We previously demonstrated that UDP-glucuronosyltransferase (UGT) 2B7 suppressed CYP3A4 activity through an interaction. In the pres...

journal_title：British journal of pharmacology

authors： Miyauchi Y,Tanaka Y,Nagata K,Yamazoe Y,Mackenzie PI,Yamada H,Ishii Y

更新日期：2020-03-01 00:00:00

abstract：:Among the five human 5-HT(4) (h5-HT(4)) receptor isoforms, the h5-HT(4(a)) receptor was studied with a particular emphasis on the molecular interactions involved in ligand binding. For this purpose, we used site-directed mutagenesis of the transmembrane domain. Twelve mutants were constructed with a special focus on t...

journal_title：British journal of pharmacology

authors： Mialet J,Dahmoune Y,Lezoualc'h F,Berque-Bestel I,Eftekhari P,Hoebeke J,Sicsic S,Langlois M,Fischmeister R

更新日期：2000-06-01 00:00:00

abstract：:In this issue, BJP is proud to publish an Endothelium Themed Section to celebrate the life of Robert F. Furchgott, who died on May 19th 2009. It is 30 years since he discovered endothelium-derived relaxant factor and a decade since he was awarded the Nobel Prize for this work. His discovery has led to an array of new ...

journal_title：British journal of pharmacology

authors： McGrath JC

更新日期：2009-06-01 00:00:00

abstract：:1. To determine how pretreatment with sulphonylureas alters the beta cell function, mouse islets were cultured (18 - 20 h) without (controls) or with (test) 0.01 microM glibenclamide. Acute responses to glucose were then determined in the absence of glibenclamide. 2. Test islets were insensitive to drugs (sulphonylure...

journal_title：British journal of pharmacology

authors： Anello M,Gilon P,Henquin JC

更新日期：1999-08-01 00:00:00

abstract：:1. The release of prostaglandin D2 (PGD2) during immediate allergic reactions in human skin was investigated in vivo and in vitro. 2. Skin exudates were collected from abraded sites on the thigh of atopic subjects sensitive to D. pteronyssinus antigen and from non-atopic control subjects. Challenge with antigen caused...

journal_title：British journal of pharmacology

authors： Barr RM,Koro O,Francis DM,Black AK,Numata T,Greaves MW

更新日期：1988-07-01 00:00:00

abstract：:1. We previously reported that substance P and insulin-like growth factor-1 (IGF-1) synergistically stimulate corneal epithelial wound healing in vitro and in vivo. We wished to identify which portion of the amino acid sequence of substance P might be responsible for this synergism. 2. Corneal epithelial migration was...

journal_title：British journal of pharmacology

authors： Nakamura M,Chikama T,Nishida T

更新日期：1999-05-01 00:00:00

abstract：:Intracellular potentials were recorded from rabbit atria, cardiac Purkinje cells and papillary muscles before and after exposure to various concentrations of indecainide. The effects of aprindine also were studied in the atrial preparations. Both drugs depressed the maximum rate of depolarization (MRD) in a dose-relat...

journal_title：British journal of pharmacology

authors： Dennis PD,Vaughan Williams EM

更新日期：1985-05-01 00:00:00

abstract：:1 A 3 min intracoronary infusion of adenosine (50 mug/min) produced a significant decrease in coronary artery perfusion pressure, left ventricular systolic pressure and myocardial O2 consumption in the isolated supported heart preparation of the dog perfused at a constant coronary blood flow. Heart rate was controlled...

journal_title：British journal of pharmacology

authors： Gross GJ,Hardman HF,Warltier DC

更新日期：1976-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS, and one of the most common causes of disability in young adults. Over the last decade, new disease-modifying therapies have emerged, including monoclonal antibodies (mAbs) that provide highly targeted therapies with greater efficacy than platform th...

journal_title：British journal of pharmacology

authors： Nguyen AL,Gresle M,Marshall T,Butzkueven H,Field J

更新日期：2017-07-01 00:00:00

abstract：:The relative potencies of a series of substance P analogues have been determined for spasmogenic activity in the guinea-pig ileum in vitro and for the release of 86Rb and alpha-amylase activity from rat parotid gland slices in vitro. Equipotent molar ratios (EMR), relative to substance P, were determined for all the c...

journal_title：British journal of pharmacology

authors： Gater PR,Jordan CC,Owen DG

更新日期：1982-02-01 00:00:00

abstract：:1. Cumulative concentration-response curves (CRC) to prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2alpha (0.01-30 microM) and to the thromboxane A2 (TXA2) receptor agonist U-46619 (0.01-30 microM) were constructed in human isolated detrusor muscle strips both in basal conditions and during electrical field stimulation. ...

journal_title：British journal of pharmacology

authors： Palea S,Toson G,Pietra C,Trist DG,Artibani W,Romano O,Corsi M

更新日期：1998-07-01 00:00:00

abstract：:1. Nine non-steroidal anti-inflammatory drugs were tested for antagonism of bradykinin-induced bronchoconstriction in guinea-pig lungs in vivo. Only one, benzydamine, was inactive.2. The descending order of potency of the active anti-inflammatory drugs was meclofenamate = Scha 306>Scha 87/2>indoxole>Mi85>indomethacin>...

journal_title：British journal of pharmacology

authors： Collier HO,James GW,Piper PJ

更新日期：1968-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The adenosine 2B (A2B) receptor is the predominant adenosine receptor expressed in the colon. Acting through the A2B receptor, adenosine mediates chloride secretion, as well as fibronectin and interleukin (IL)-6 synthesis and secretion in intestinal epithelial cells. A2B receptor mRNA and protein...

journal_title：British journal of pharmacology

authors： Kolachala V,Ruble B,Vijay-Kumar M,Wang L,Mwangi S,Figler H,Figler R,Srinivasan S,Gewirtz A,Linden J,Merlin D,Sitaraman S

更新日期：2008-09-01 00:00:00

abstract：:Glycogen synthase kinase 3 (GSK3), a constitutively acting multi-functional serine threonine kinase is involved in diverse physiological pathways ranging from metabolism, cell cycle, gene expression, development and oncogenesis to neuroprotection. These diverse multiple functions attributed to GSK3 can be explained by...

journal_title：British journal of pharmacology

authors： Rayasam GV,Tulasi VK,Sodhi R,Davis JA,Ray A

更新日期：2009-03-01 00:00:00

abstract：:1. The vascular actions of the proteinase-activated receptor-2-activating peptides (PAR2APs), SLIGRL-NH2 (SL-NH2) and SLIGKV-NH2 (KV-NH2) as well as the reverse-sequence peptide, LSIGRL-NH2 (LS-NH2) and an N-acylated PAR2AP derivative, trans-cinnamoyl-LIGRLO-NH2 (tcLI-NH2), were studied in rat intact and endothelium-d...

journal_title：British journal of pharmacology

authors： Roy SS,Saifeddine M,Loutzenhiser R,Triggle CR,Hollenberg MD

更新日期：1998-04-01 00:00:00