Distinct functions of endogenous cannabinoid system in alcohol abuse disorders.

abstract：:1. The presence of an endogenous digitalis-like factor (EDLF) in the plasma of both normal and volume expanded animals is well documented. In this study we have used ouabain and bufalin as pharmacological analogues to mimic the renal effects of EDLF and to investigate whether any interaction occurs between atrial natr...

journal_title：British journal of pharmacology

authors： Yates NA,McDougall JG

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:An innovative chemical approach, named peptide welding technology (PWT), allows the synthesis of multibranched peptides with extraordinary high yield, purity and reproducibility. With this approach, three different tetrabranched derivatives of nociceptin/orphanin FQ (N/OFQ) have been synthesized ...

journal_title：British journal of pharmacology

authors： Rizzi A,Malfacini D,Cerlesi MC,Ruzza C,Marzola E,Bird MF,Rowbotham DJ,Salvadori S,Guerrini R,Lambert DG,Calo G

更新日期：2014-09-01 00:00:00

abstract：:1. The effects of various inhibitors of the mitochondrial electron transport chain on the activity of ATP-sensitive K+ channels were examined in the Cambridge rat insulinoma G1 (CRI-G1) cell line using a combination of whole cell and single channel recording techniques. 2. Whole cell current clamp recordings, with 5 m...

journal_title：British journal of pharmacology

authors： Harvey J,Hardy SC,Ashford ML

更新日期：1999-01-01 00:00:00

abstract：:By implanting a Teflon chamber subcutaneously into a sheep a mild aseptic inflammatory lesion was produced from which wound fluid could be sampled daily. The prostaglandin content of this wound fluid was examined. Prostaglandin E2 activity was found in all samples, and a peak was apparent on the fourth or fifth day af...

journal_title：British journal of pharmacology

authors： Greenwood B,Kerry PJ

更新日期：1975-02-01 00:00:00

abstract：:Dopamine, noradrenaline (NA) and adrenaline (Ad) depletion by 6-hydroxydopamine (6-OHDA) and pargyline plus 6-OHDA was investigated in the cat left ventricle, mesenteric and renal arteries, renal cortex, renal medulla and adrenal medulla. Catecholamine concentrations in plasma were also analyzed in these two experimen...

journal_title：British journal of pharmacology

authors： Caramona MM,Soares-da-Silva P

更新日期：1985-10-01 00:00:00

abstract：:1 Hypolipidaemic agents may increase biliary cholesterol in man, inducing a supersaturated bile. 2 To evaluate this possible side-effect, we have studied bile lipid secretion over a period of 8 h with intact enterohepatic circulation and 4 h with complete interruption in rats treated for two months with a salt of chol...

journal_title：British journal of pharmacology

authors： Aldini R,Barbara L,Benelli A,Borzatta V,Geminiani S,Mascellani G,Morselli A,Roda A,Roda E

更新日期：1981-11-01 00:00:00

abstract：:1. The purpose of the present study was to determine the myocardial cytoprotective efficacy of azapropazone (AZA) and its potential site of action on neutrophil infiltration into reperfused/ischaemic myocardium with or without in vivo activation of neutrophils in rabbits. 2. AZA, 100 mg kg-1, was administered i.v. 10 ...

journal_title：British journal of pharmacology

authors： Mousa SA,Brown R,Thoolen MJ,Smith RD

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agonists of the M(2) muscarinic acetylcholine receptor (mAChR) increase mRNA for this receptor and mRNA for endothelial and neuronal isoforms of NO synthase (eNOS or nNOS). Here we examine the different signalling pathways involved in such events in rat cardiac atria. EXPERIMENTAL APPROACH:In is...

journal_title：British journal of pharmacology

authors： Ganzinelli S,Joensen L,Borda E,Bernabeo G,Sterin-Borda L

更新日期：2007-05-01 00:00:00

abstract：:1. Cumulative concentration-response curves (CRC) to prostaglandin E1 (PGE1), PGE2, PGD2 and PGF2alpha (0.01-30 microM) and to the thromboxane A2 (TXA2) receptor agonist U-46619 (0.01-30 microM) were constructed in human isolated detrusor muscle strips both in basal conditions and during electrical field stimulation. ...

journal_title：British journal of pharmacology

authors： Palea S,Toson G,Pietra C,Trist DG,Artibani W,Romano O,Corsi M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Peptide YY (PYY) and neuropeptide Y (NPY) activate Y receptors, targets under consideration as treatments for diarrhoea and other intestinal disorders. We investigated the gastrointestinal consequences of selective PYY or NPY ablation on mucosal ion transport, smooth muscle activity and transit u...

journal_title：British journal of pharmacology

authors： Tough IR,Forbes S,Tolhurst R,Ellis M,Herzog H,Bornstein JC,Cox HM

更新日期：2011-09-01 00:00:00

abstract：:1. We have investigated the effects of the selective phosphodiesterase (PDE) type 4 inhibitor, rolipram (0.01-1 microM) on cytosolic Ca2+ fluxes in FMLP-activated human neutrophils, as well as on superoxide production by, and release of elastase from, these cells. 2. Cytosolic Ca2+ fluxes were measured by use of fura-...

journal_title：British journal of pharmacology

authors： Anderson R,Goolam Mahomed A,Theron AJ,Ramafi G,Feldman C

更新日期：1998-06-01 00:00:00

abstract：:In the rabbit isolated pulmonary artery, neither the ETA receptor antagonist, BQ-123 (10 microM), nor the ETB receptor antagonist, BQ-788 (10 microM), inhibited the contractions induced by 1 nM endothelin-1 (ET-1). However, the combination of BQ-123 and BQ-788 completely inhibited the ET-1-induced contraction. In cont...

journal_title：British journal of pharmacology

authors： Fukuroda T,Ozaki S,Ihara M,Ishikawa K,Yano M,Nishikibe M

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:AZ11645373 and N-{2-methyl-5-[(1R, 5S)-9-oxa-3,7-diazabicyclo[3.3.1]non-3-ylcarbonyl]phenyl}-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide hydrochloride (compound-22) are recently described P2X(7) receptor antagonists. In this study we have further characterized these compounds to determine their mecha...

journal_title：British journal of pharmacology

authors： Michel AD,Ng SW,Roman S,Clay WC,Dean DK,Walter DS

更新日期：2009-04-01 00:00:00

abstract：:1. The inhibitory effect of erythrocyte suspensions and haemoglobin solutions on the response of the bovine retractor penis muscle (BRP) and the rat anococcygeus to field stimulation of their non-adrenergic non-cholinergic (NANC) nerves has been compared. Haemoglobin 3 microM greatly reduced the relaxant response in b...

journal_title：British journal of pharmacology

authors： Gillespie JS,Sheng H

更新日期：1989-10-01 00:00:00

abstract：:The properties of the ATPase released during electrical field stimulation (EFS) (8 Hz, 25 s) of the sympathetic nerves of the superfused rabbit isolated vas deferens were investigated. Superfusate collected during EFS rapidly metabolised exogenous ATP (100 microM) and 50% was broken down in 5.67+/-0.65 min. The main m...

journal_title：British journal of pharmacology

authors： Westfall TD,Menzies JR,Liberman R,Waterston S,Ramphir N,Westfall DP,Sneddon P,Kennedy C

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Partial agonists selective for α4β2 nicotinic ACh receptors have been developed for smoking cessation as they induce weak activation of native α4β2* receptors and inhibit effect of nicotine. However, it is unclear whether at brain functions there is an existence of receptor reserve that allows we...

journal_title：British journal of pharmacology

authors： Chen Y,Broad LM,Phillips KG,Zwart R

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sonic hedgehog pathway (Shh) plays a central role in maintaining stem cell function and behaviour in various processes related to self-renewal and tissue regeneration. However, the therapeutic effect of Shh on mouse embryonic stem cells (mESCs) has not yet been clearly elucidated. Thus, we in...

journal_title：British journal of pharmacology

authors： Oh JY,Suh HN,Choi GE,Lee HJ,Jung YH,Ko SH,Kim JS,Chae CW,Lee CK,Han HJ

更新日期：2018-09-01 00:00:00

abstract：LINKED ARTICLES:This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc. ...

journal_title：British journal of pharmacology

authors： Summers RJ

更新日期：2017-05-01 00:00:00

abstract：:Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack ...

journal_title：British journal of pharmacology

authors： Elliott JI,Raguz S,Higgins CF

更新日期：2004-12-01 00:00:00

abstract：:1. In circular smooth muscle of the guinea-pig gastric fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.), and blockade of the e.j.p. by atropine revealed a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). 2. The amplitude of the e.j.p. was inc...

journal_title：British journal of pharmacology

authors： Ohno N,Xue L,Yamamoto Y,Suzuki H

更新日期：1996-03-01 00:00:00

abstract：:1. FPL 67156 (6-N,N-diethyl-beta, gamma-dibromomethylene-D-ATP), is a newly synthesized analogue of ATP. 2. In a rabbit isolated tracheal epithelium preparation, measuring P2U-purinoceptor-dependent chloride secretion, FPL 67156 was discovered to potentiate the responses to UTP but not those to ATP-gamma-S. UTP agonis...

journal_title：British journal of pharmacology

authors： Crack BE,Pollard CE,Beukers MW,Roberts SM,Hunt SF,Ingall AH,McKechnie KC,IJzerman AP,Leff P

更新日期：1995-01-01 00:00:00

abstract：:Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this rev...

journal_title：British journal of pharmacology

authors： Zhang SY,Xu MJ,Wang X

更新日期：2018-04-01 00:00:00

abstract：:PPARδ is a ligand-activated receptor that dimerizes with another nuclear receptor of the retinoic acid receptor family. The dimers interact with other co-activator proteins and form active complexes that bind to PPAR response elements and promote transcription of genes involved in lipid metabolism. It appears that var...

journal_title：British journal of pharmacology

authors： Kahremany S,Livne A,Gruzman A,Senderowitz H,Sasson S

更新日期：2015-02-01 00:00:00

abstract：:1 The reversible fatty acid amide hydrolase (FAAH) inhibitor OL135 reverses mechanical allodynia in the spinal nerve ligation (SNL) and mild thermal injury (MTI) models in the rat. The purpose of this study was to investigate the role of the cannabinoid and opioid systems in mediating this analgesic effect. 2 Elevated...

journal_title：British journal of pharmacology

authors： Chang L,Luo L,Palmer JA,Sutton S,Wilson SJ,Barbier AJ,Breitenbucher JG,Chaplan SR,Webb M

更新日期：2006-05-01 00:00:00

abstract：:1. To investigate the quantitative relationship between elevation in the intracellular Ca(2+) concentration ([Ca(2+)](i)) and nitric oxide (NO) production, the changes in [Ca(2+)](i) and NO production were determined in parallel, using fluorimetry of fura-2 and 2, 3-diaminonaphthalene, respectively, in endothelial cel...

journal_title：British journal of pharmacology

authors： Mizuno O,Kobayashi S,Hirano K,Nishimura J,Kubo C,Kanaide H

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The cannabinoid receptor-mediated analgesic effects of 2-arachidonoylglycerol (2-AG) are limited by monoacylglycerol lipase (MAGL). 4-nitrophenyl 4-[bis (1,3-benzodioxol-5-yl) (hydroxy) methyl] piperidine-1-carboxylate (JZL184) is a potent inhibitor of MAGL in the mouse, though potency is reporte...

journal_title：British journal of pharmacology

authors： Woodhams SG,Wong A,Barrett DA,Bennett AJ,Chapman V,Alexander SP

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:ARL 67156, 6-N,N-Diethyl-D-beta-gamma-dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available inhibitor of ecto-ATPases. Since the first report on this molecule, various ectonucleotidases responsible for the hydrolysis of ATP at the cell surface hav...

journal_title：British journal of pharmacology

authors： Lévesque SA,Lavoie EG,Lecka J,Bigonnesse F,Sévigny J

更新日期：2007-09-01 00:00:00

abstract：:Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and inhibits stimulated adenylate cyclase. Adenosine 5'-O-(1-thiodiphosphate) (ADP-alpha-S) and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) act at the ADP receptor and achieve the same maximal rate of human platelet aggregation as each other. Adenos...

journal_title：British journal of pharmacology

authors： Cusack NJ,Hourani SM

更新日期：1982-02-01 00:00:00

abstract：:1. Adenosine has been shown to be responsible for the hyperaemic response of the hepatic artery to portal vein occlusion (the hepatic arterial 'buffer response'). 2. The effect of adenosine receptor blockade and of adenosine uptake inhibition on the hepatic arterial response to portal vein occlusion was investigated i...

journal_title：British journal of pharmacology

authors： Mathie RT,Alexander B

更新日期：1990-07-01 00:00:00

abstract：:In the present study we used a bioassay to study the effects of peroxynitrite (ONOO-) on angiotensin II (A-II)-triggered tension in isolated bovine coronary arteries in order to show the consequences of the previously reported PGI2-synthase inhibition by ONOO- in this model. The following results were obtained: 1. 1 m...

journal_title：British journal of pharmacology

authors： Zou M,Jendral M,Ullrich V

更新日期：1999-03-01 00:00:00