Antagonism by fenamates and like-acting drugs of bronchoconstriction induced by bradykinin or antigen in the guinea-pig.

abstract：:1. Release-regulating alpha 2-autoreceptors in human brain were characterized pharmacologically in cortical slices from patients undergoing neurosurgery to remove subcortical tumours; the slices were prelabelled with [3H]-noradrenaline ([3H]-NA) and stimulated electrically (3 Hz, 2 ms, 24 mA) under superfusion conditi...

journal_title：British journal of pharmacology

authors： Raiteri M,Bonanno G,Maura G,Pende M,Andrioli GC,Ruelle A

更新日期：1992-12-01 00:00:00

abstract：:Eotaxin is a novel C-C chemokine with selective chemoattractant activity for eosinophils. We determined whether eotaxin could be produced by human airway smooth muscle (HASM) cells in culture and examined its regulation by interleukin-10 (IL-10) and the corticosteroid, dexamethasone. Stimulation of the cells with inte...

journal_title：British journal of pharmacology

authors： Chung KF,Patel HJ,Fadlon EJ,Rousell J,Haddad EB,Jose PJ,Mitchell J,Belvisi M

更新日期：1999-07-01 00:00:00

abstract：:1. Gallamine, dequalinium and a novel bis-quaternary cyclophane, UCL 1530 (8,19-diaza-3(1,4),5(1,4)-dibenzena-1 (1,4),7(1,4)-diquinolina-cyclononadecanephanedium) were tested for their ability to block actions mediated by the small conductance, apamin-sensitive Ca(2+)-activated K+ (SKCa) channels in rat cultured sympa...

journal_title：British journal of pharmacology

authors： Dunn PM,Benton DC,Campos Rosa J,Ganellin CR,Jenkinson DH

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischaemia compromises mitochondrial respiration. Consequently, the mitochondrial F1 Fo-ATPsynthase reverses and acts as a proton-pumping ATPase, so maintaining the mitochondrial membrane potential (ΔΨm ), while accelerating ATP depletion and cell death. Here we have looked for a molecule that can...

journal_title：British journal of pharmacology

authors： Ivanes F,Faccenda D,Gatliff J,Ahmed AA,Cocco S,Cheng CH,Allan E,Russell C,Duchen MR,Campanella M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Hydrogen sulphide (H2 S) is an endogenous gaseous signalling molecule with putative functions in gastrointestinal motility regulation. Characterization of H2 S effects on colonic motility is crucial to establish its potential use as therapeutic agent in the treatment of colonic disorders. EXPERI...

journal_title：British journal of pharmacology

authors： Gil V,Parsons S,Gallego D,Huizinga J,Jimenez M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A functional link between seizure-induced P-glycoprotein overexpression at the blood-brain barrier and therapeutic failure has been suggested by several studies using rodent epilepsy models and human epileptic tissue. Recently, we reported that interference with the mechanisms that up-regulate P-...

journal_title：British journal of pharmacology

authors： Schlichtiger J,Pekcec A,Bartmann H,Winter P,Fuest C,Soerensen J,Potschka H

更新日期：2010-07-01 00:00:00

abstract：:We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by alpha-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages. DFMO potentiated LPS-stimulated nitrite production in both a concentration- and t...

journal_title：British journal of pharmacology

authors： Baydoun AR,Morgan DM

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Cerebrovascular remodelling is one of the important risk factors of stroke. The underlying mechanisms are unclear. Integrin β3 and volume-regulated ClC-3 Cl(-) channels have recently been implicated as important contributors to vascular cell proliferation. Therefore, we investigated the role of i...

journal_title：British journal of pharmacology

authors： Zeng JW,Wang XG,Ma MM,Lv XF,Liu J,Zhou JG,Guan YY

更新日期：2014-07-01 00:00:00

abstract：:1. The modulation of 4-aminopyridine sensitive transient outward potassium current (4-AP I(to)) by neuropeptide Y (NPY) (100 nM) in rat ventricular myocytes was examined using the whole cell voltage-clamp technique. 2. Continuous exposure to NPY (100 nM) for 3 - 6 h significantly increased 4-AP I(to) density. The stim...

journal_title：British journal of pharmacology

authors： Heredia MP,Fernández-Velasco M,Benito G,Delgado C

更新日期：2002-04-01 00:00:00

abstract：:1. The effect of intravenous administration of dexamphetamine [+)-Amp) on rat pupil diameter was investigated. In all experiments, the vagosympathetic trunks were sectioned bilaterally at the cervical level. 2. In rats anaesthetized with urethane, (+)-Amp (0.1-0.3 mg kg-1, i.v.) produced a dose-related increase in pup...

journal_title：British journal of pharmacology

authors： Hey JA,Ito T,Koss MC

更新日期：1989-01-01 00:00:00

abstract：:1. The effect of NMDA-receptor stimulation on phosphoinositide signalling in response to the metabotropic glutamate receptor agonist 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) has been examined in neonatal rat cerebral cortex slices. 2. Total [3H]-inositol phosphate ([3H]-InsPx) accumulation, in the pres...

journal_title：British journal of pharmacology

authors： Challiss RA,Mistry R,Gray DW,Nahorski SR

更新日期：1994-05-01 00:00:00

abstract：:1. The brain cytoprotective effects of a putative calcium-associated protein kinase inhibitor, HA1077, as well as a calcium entry blocker nicardipine were evaluated in models of cerebral ischaemia in Mongolian gerbils. Morphological changes characterizing delayed neuronal death of selectively vulnerable CA1 pyramidal ...

journal_title：British journal of pharmacology

authors： Asano T,Ikegaki I,Satoh S,Mochizuki D,Hidaka H,Suzuki Y,Shibuya M,Sugita K

更新日期：1991-08-01 00:00:00

abstract：:1. The influence of angiotensin II (AII) on resting blood pressure and on sympathetic nerve-mediated pressor responses in the pithed rat was investigated either by inhibiting the renin-angiotensin system or by infusing AII. 2. Plasma AII levels in the pithed rat were approximately 20 fold higher than in normotensive r...

journal_title：British journal of pharmacology

authors： Grant TL,McGrath JC

更新日期：1988-12-01 00:00:00

abstract：:1. The action of substance P (SP) on the release of gamma-aminobutyric acid (GABA) and acetylcholine (ACh) and on contraction were studied in strips of the guinea-pig urinary bladder. Substance P induced a dose-dependent contraction of strips of guinea-pig urinary bladder (EC50 = 1.2 x 10(-9) M). This contraction was ...

journal_title：British journal of pharmacology

authors： Shirakawa J,Nakanishi T,Taniyama K,Kamidono S,Tanaka C

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sulphatides are sulphated glycosphingolipids expressed on the surface of many cell types, particularly neurones. Changes in sulphatide species or content have been associated with epilepsy and Alzheimer's disease. As the large conductance, calcium sensitive K(+) channel (BK(Ca)) are modulated by ...

journal_title：British journal of pharmacology

authors： Chi S,Qi Z

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agonists of the M(2) muscarinic acetylcholine receptor (mAChR) increase mRNA for this receptor and mRNA for endothelial and neuronal isoforms of NO synthase (eNOS or nNOS). Here we examine the different signalling pathways involved in such events in rat cardiac atria. EXPERIMENTAL APPROACH:In is...

journal_title：British journal of pharmacology

authors： Ganzinelli S,Joensen L,Borda E,Bernabeo G,Sterin-Borda L

更新日期：2007-05-01 00:00:00

abstract：:Athletes attempt to improve performance with drugs that act on the beta-adrenergic system directly or indirectly. Of three beta-adrenoceptor (AR) subtypes, the beta(2)-AR is the main target in sport; they have bronchodilator and anabolic actions and enhance anti-inflammatory actions of corticosteroids. Although demons...

journal_title：British journal of pharmacology

authors： Davis E,Loiacono R,Summers RJ

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:QT prolongation is commonly used as a surrogate marker for Torsade de Pointes (TdP) risk of non-cardiovascular drugs. However, use of this indirect marker often leads to misinterpretation of the realistic TdP risk, as tested compounds may cause QT prolongation without evoking TdP in humans. A neg...

journal_title：British journal of pharmacology

authors： Guns PJ,Johnson DM,Van Op den Bosch J,Weltens E,Lissens J

更新日期：2012-05-01 00:00:00

abstract：:1. The effects of several agonists of the metabotropic glutamate receptor (mGluR) were studied in adult rat striatal slices by measuring (i) KCl (30 mM)-induced output of previously taken up D-[3H]-aspartate (Asp), (ii) forskolin (30 microM)-induced adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation and (i...

journal_title：British journal of pharmacology

authors： Lombardi G,Alesiani M,Leonardi P,Cherici G,Pellicciari R,Moroni F

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N-arachidonyl dopamine (NADA) has been identified as a putative endocannabinoid, but there is little information about which signalling pathways it activates. The purpose of this study was to identify the signalling pathways activated by NADA in vitro. EXPERIMENTAL APPROACH:Human or rat cannabin...

journal_title：British journal of pharmacology

authors： Redmond WJ,Cawston EE,Grimsey NL,Stuart J,Edington AR,Glass M,Connor M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:alpha5IA (3-(5-methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3,4-a]phthalazine) is a triazolophthalazine with subnanomolar affinity for alpha1-, alpha2-, alpha3- and alpha5-containing GABA(A) receptors. Here we have evaluated the relationship between plasma alpha5...

journal_title：British journal of pharmacology

authors： Atack JR,Eng WS,Gibson RE,Ryan C,Francis B,Sohal B,Dawson GR,Hargreaves RJ,Burns HD

更新日期：2009-07-01 00:00:00

abstract：:1. Heterologous desensitization or intermolecular cross-talk plays a critical role in regulating intracellular signalling by diverse members of the G-protein-coupled receptor superfamily. We have previously established that the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) undergo differential de...

journal_title：British journal of pharmacology

authors： Kelley-Hickie LP,Kinsella BT

更新日期：2004-05-01 00:00:00

abstract：:Midbrain dopaminergic (DA) neurones sustain important physiological functions such as control of motricity, signalling of the error in prediction of rewards and modulation of emotions and cognition. Moreover, their degeneration leads to Parkinson's disease and they may be dysfunctional in other pathological states, su...

journal_title：British journal of pharmacology

authors： Seutin V

更新日期：2005-09-01 00:00:00

abstract：:1. CS-747 is a novel thienopyridine-type platelet ADP inhibitor which lacks in vitro activity. This study examined pharmacological profiles of R-99224, a hepatic metabolite of CS-747. 2. R-99224 produced a concentration-dependent inhibition of in vitro platelet aggregation in washed human platelets (0.03 - 1 microg ml...

journal_title：British journal of pharmacology

authors： Sugidachi A,Asai F,Yoneda K,Iwamura R,Ogawa T,Otsuguro K,Koike H

更新日期：2001-01-01 00:00:00

abstract：:1. Previous patch clamp studies of oesophageal circular muscle cells showed that nitric oxide (NO) modulated the opening of Ca2(+)-activated K+ channels involved in mediating the inhibitory junction potentials (i.j.ps). This study clarified the role of Ca2+ release from the superficial sarcoplasmic reticulum (SR) in t...

journal_title：British journal of pharmacology

authors： Cayabyab FS,Daniel EE

更新日期：1996-08-01 00:00:00

abstract：:1. The influence of feeding 2 levels of sotalol on the incidence of beta-aminopropionitrile (BAPN)-induced aortic ruptures of immature turkeys was determined.2. Four of 22 turkeys fed 0.12% sotalol and 0.07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.3. Blood pressure, heart r...

journal_title：British journal of pharmacology

authors： Simpson CF

更新日期：1972-07-01 00:00:00

abstract：:1. The subtype of alpha1-adrenoceptor mediating contractions to phenylephrine of the rat thoracic aorta, mesenteric artery and pulmonary artery were investigated by use of antagonists which show selectivity between the cloned alpha1-adrenoceptor subtypes in binding studies. 2. Cumulative concentration-contraction curv...

journal_title：British journal of pharmacology

authors： Hussain MB,Marshall I

更新日期：1997-11-01 00:00:00

abstract：:1. Adenosine 5'-triphosphate (ATP) is known to augment cardiac contractile activity and cause an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in isolated cardiomyocytes. However, no information regarding the ATP-mediated signal transduction in the myocardium in congestive heart failure (CHF) is availab...

journal_title：British journal of pharmacology

authors： Saini HK,Shao Q,Musat S,Takeda N,Tappia PS,Dhalla NS

更新日期：2005-01-01 00:00:00

abstract：:The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the ...

journal_title：British journal of pharmacology

authors： Hyslop DK,Taylor DP

更新日期：1980-01-01 00:00:00

abstract：:Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spo...

journal_title：British journal of pharmacology

authors： Holman ME,Spitzer NC

更新日期：1973-02-01 00:00:00