Abstract:
:1. The influence of angiotensin II (AII) on resting blood pressure and on sympathetic nerve-mediated pressor responses in the pithed rat was investigated either by inhibiting the renin-angiotensin system or by infusing AII. 2. Plasma AII levels in the pithed rat were approximately 20 fold higher than in normotensive rats. 3. Infusion of a subpressor dose of AII (50 ng kg-1 min-1) had no effect on sympathetic nerve mediated pressor responses but a pressor dose of AII, (200 ng kg-1 min-1) facilitated nerve-mediated pressor responses. 4. The angiotensin converting enzyme inhibitor, teprotide, and the AII-receptor antagonist, saralasin, lowered the diastolic blood pressure and attenuated sympathetic nerve-mediated pressor responses. There was no difference in the effects of teprotide at 1 mg kg-1 and 10 mg kg-1. Infusion of sodium nitroprusside at concentrations producing a fall in diastolic blood pressure of similar magnitude to that produced by teprotide and saralasin significantly attenuated nerve-mediated pressor responses. 5. After teprotide, AII 50 mg kg-1 min-1 increased diastolic blood pressure. The inhibitory effect of teprotide on nerve-mediated pressor responses was antagonized by this infusion of AII only if the rats were pretreated with the cyclo-oxygenase inhibitor, flurbiprofen. 6. It is concluded that AII is a major determinant of vascular tone in the pithed rat and that inhibition of the renin-angiotensin system attenuates sympathetic nerve-mediated pressor responses at least in part through the fall in blood pressure per se. The demonstration of this is complicated by an excessive release of vasodilator prostaglandins possibly due to the infused AII. Since plasma All levels are high, the effects of blockade of the renin-angiotensin system will be exaggerated and so the importance of All as a modulator of sympathetic responses will be overestimated in this model.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Grant TL,McGrath JCdoi
10.1111/j.1476-5381.1988.tb11759.xsubject
Has Abstractpub_date
1988-12-01 00:00:00pages
1220-8issue
4eissn
0007-1188issn
1476-5381journal_volume
95pub_type
杂志文章abstract::1. By use of patch-clamp techniques, the effects of SD-3212, a novel antiarrhythmic drug, on the calcium current (Ica), the sodium current (INa) and the muscarinic acetylcholine-receptor-operated potassium current (IK.ACh) were examined and compared with those of bepridil in guinea-pig single atrial cells. 2. SD-3212 ...
journal_title:British journal of pharmacology
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abstract:BACKGROUND AND PURPOSE:Macropinocytosis is involved in many pathologies, including cardiovascular disorders, cancer, allergic diseases, viral and bacterial infections. Unfortunately, the currently available pharmacological inhibitors of macropinocytosis interrupt other endocytic processes and have non-specific endocyto...
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