Role of the chemoreceptor trigger zone in cyclopropane induced emesis in dogs.

Abstract:

:Inhalation of cyclopropane in dogs, by the closed circuit method, for a fixed period, produced an emetic response during recovery from anaesthesia. Bilateral surgical ablation of the emetic chemoreceptor trigger zone of the area postrema rendered the dogs refractory to several times (3-6) the threshold emetic dose of cyclopropane.

journal_name

Br J Pharmacol

authors

Badola RP,Bhargava KP,Dixit KS,Ratra CK

doi

10.1111/j.1476-5381.1971.tb07174.x

subject

Has Abstract

pub_date

1971-09-01 00:00:00

pages

248-9

issue

1

eissn

0007-1188

issn

1476-5381

journal_volume

43

pub_type

杂志文章
  • The effects of some beta-adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart.

    abstract::1. The potencies of some beta-adrenoreceptor blocking drugs in reducing noradrenaline uptake by the isolated heart were compared with their potencies in reducing the release of noradrenaline from the heart by tyramine.2. Of the drugs tested, propranolol, pronethalol and dichloroisoprenaline were the most potent in blo...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1968.tb07957.x

    authors: Foo JW,Jowett A,Stafford A

    更新日期:1968-09-01 00:00:00

  • Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis.

    abstract::AM-36 is a novel neuroprotective agent incorporating both antioxidant and Na(+) channel blocking actions. In cerebral ischaemia, loss of cellular ion homeostasis due to Na(+) channel activation, together with increased reactive oxygen species (ROS) production, are thought to contribute to neuronal death. Since neurona...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704018

    authors: Callaway JK,Beart PM,Jarrott B,Giardina SF

    更新日期:2001-04-01 00:00:00

  • nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.

    abstract:BACKGROUND AND PURPOSE:Anxiety disorder is a common mental health disorder. However, there are few safe and fast-acting anxiolytic drugs available that can treat anxiety disorder. We previously demonstrated that the interaction of neuronal NOS (nNOS) with its carboxy-terminal PDZ ligand (CAPON) is involved in regulatin...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.15084

    authors: Zhu LJ,Shi HJ,Chang L,Zhang CC,Si M,Li N,Zhu DY

    更新日期:2020-08-01 00:00:00

  • ICI D7114 a novel selective beta-adrenoceptor agonist selectively stimulates brown fat and increases whole-body oxygen consumption.

    abstract::1. ICI D7114 is a novel, beta-adrenoceptor agonist which stimulates whole body oxygen consumption in conscious rats, cats and dogs and brown adipose tissue (BAT) activity in conscious rats. Treatment of rats with ICI D7114 stimulated oxygen consumption (ED50, 0.04 mg kg-1, p.o.) and BAT mitochondrial guanosine diphosp...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1991.tb12391.x

    authors: Holloway BR,Howe R,Rao BS,Stribling D,Mayers RM,Briscoe MG,Jackson JM

    更新日期:1991-09-01 00:00:00

  • Release of gamma-aminobutyric acid and acetylcholine by neurotensin in guinea-pig ileum.

    abstract::The release of gamma-aminobutyric acid (GABA) and acetylcholine (ACh) from the strips of guinea-pig ileum was investigated in the presence of neurotensin. Neurotensin evoked the release of [3H]-GABA from the strips preloaded with [3H]-GABA, and the evoked release was Ca2+-dependent and tetrodotoxin-sensitive. Hexameth...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1987.tb11204.x

    authors: Nakamoto M,Tanaka C,Taniyama K

    更新日期:1987-03-01 00:00:00

  • Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line.

    abstract::Peroxisome proliferator activated receptors (PPAR)s are nuclear transcription factors of the steroid receptor super-family. One member, PPARgamma, a critical transcription factor in adipogenesis, is expressed in ECV304 cells, and when activated participates in the induction of cell death by apoptosis. Here we describe...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0703628

    authors: Bishop-Bailey D,Hla T,Warner TD

    更新日期:2000-10-01 00:00:00

  • The effect of parachlorophenylalanine on social interaction of male rats.

    abstract::1. Juvenile male rats treated with parachlorophenylalanine showed hair loss round the head and neck extending down the chest and abdomen.2. Treated isolated rats did not have this loss of hair, while untreated animals living in the same cage as treated rats lost their hair. The loss therefore seems to be caused by inc...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1970.tb08518.x

    authors: Shillito EE

    更新日期:1970-02-01 00:00:00

  • A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig.

    abstract::1. The purpose of this study was to compare the pharmacological properties (i.e. the AV nodal depressant, vasodilator, and inotropic effects) of two AV nodal blocking agents belonging to different drug classes; a novel A1 adenosine receptor (A1 receptor) agonist, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside (CVT-...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0702287

    authors: Snowdy S,Liang HX,Blackburn B,Lum R,Nelson M,Wang L,Pfister J,Sharma BP,Wolff A,Belardinelli L

    更新日期:1999-01-01 00:00:00

  • The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor.

    abstract::Transient expression in COS-7 cells of the recombinant human 5-hydroxytryptamine (5-HT) h5-HT4(c) receptor isoform led to constitutive activity of the receptor. The 5-HT4 receptor antagonist 2-(cis-3,5-dimethylpiperidino)ethyl 4-amino-5-chloro-2-methoxybenzoate (ML10375) at 1 microM completely abolished the 5-HT (1 mi...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0702163

    authors: Blondel O,Gastineau M,Langlois M,Fischmeister R

    更新日期:1998-10-01 00:00:00

  • Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.

    abstract:BACKGROUND AND PURPOSE:The psychostimulant cocaine induces complex molecular, cellular and behavioural responses as a consequence of inhibiting presynaptic dopamine, noradrenaline and 5-HT transporters. To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SE...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13899

    authors: Simmler LD,Anacker AMJ,Levin MH,Vaswani NM,Gresch PJ,Nackenoff AG,Anastasio NC,Stutz SJ,Cunningham KA,Wang J,Zhang B,Henry LK,Stewart A,Veenstra-VanderWeele J,Blakely RD

    更新日期:2017-08-01 00:00:00

  • Mechanism of anti-inflammatory action of glucocorticoids: re-evaluation of vascular constriction hypothesis.

    abstract::1 The question whether constriction of local vessels is essential for the anti-inflammatory action of glucocorticoids in carrageenin-induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E1 injection into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma t...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1981.tb16794.x

    authors: Sugio K,Tsurufuji S

    更新日期:1981-07-01 00:00:00

  • Some derivatives of polyvinylpyridine 1-oxides and their effect on the cytotoxicity of quartz in macrophage cultures.

    abstract::1. Poly(2-vinylpyridine 1-oxide) counteracts the pathogenic effects normally produced when quartz is injected into or inhaled by animals and the cytotoxic effects when quartz is added to macrophage cultures. The protective action of this polymer has been attributed variously to the formation of an adsorbed layer on th...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1970.tb10347.x

    authors: Holt PF,Lindsay H,Beck EG

    更新日期:1970-01-01 00:00:00

  • Two distinct membrane currents activated by cyclopiazonic acid-induced calcium store depletion in single smooth muscle cells of the mouse anococcygeus.

    abstract::1. By use of the whole-cell configuration of the patch-clamp technique, membrane currents induced by cyclopiazonic acid (CPA; an inhibitor of the sarcoplasmic reticulum (SR) calcium-ATPase) were investigated in single smooth muscle cells freshly dispersed from the mouse anococcygeus. Voltage-dependent calcium currents...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1996.tb15228.x

    authors: Wayman CP,McFadzean I,Gibson A,Tucker JF

    更新日期:1996-02-01 00:00:00

  • A tachykinin antagonist inhibits gastric emptying and gastrointestinal transit in the rat.

    abstract::The effect of a substance P antagonist, [D-Pro2, D-Trp7,9]-substance P (SPA), on gastric emptying and gastrointestinal transit in the rat was studied in order to elucidate a possible physiological role of endogenous substance P and other tachykinins in gastrointestinal motility. SPA was given by intraperitoneal inject...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1986.tb11144.x

    authors: Holzer P,Holzer-Petsche U,Leander S

    更新日期:1986-11-01 00:00:00

  • Inhibition of human recombinant T-type calcium channels by N-arachidonoyl 5-HT.

    abstract:BACKGROUND AND PURPOSE:N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH). Anandamide and N-arachidonoyl dopamine (NA-DA), endocannabinoids that activate TRPV1 or a...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2012.02047.x

    authors: Gilmore AJ,Heblinski M,Reynolds A,Kassiou M,Connor M

    更新日期:2012-11-01 00:00:00

  • Prostaglandin E1 potentiation of the spontaneous phasic contraction of rat isolated portal vein by a cyclopiazonic acid-sensitive mechanism.

    abstract::1. The effect of prostaglandin E1 (PGE1) on the spontaneous phasic contraction of the rat isolated portal vein was studied. 2. The isolated portal vein exhibited spontaneous phasic contractions. Removal of Ca2+ from Krebs-Ringer solution or application of nifedipine abolished the spontaneous contraction, indicating th...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0701051

    authors: Miwa T,Endou M,Okumura F

    更新日期:1997-04-01 00:00:00

  • Differential inhibition by adenosine or by prostaglandin E1 of human platelet aggregation induced by adenosine 5'-O-(1-thiodiphosphate) and adenosine 5'-O-(2-thiodiphosphate).

    abstract::Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and inhibits stimulated adenylate cyclase. Adenosine 5'-O-(1-thiodiphosphate) (ADP-alpha-S) and adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) act at the ADP receptor and achieve the same maximal rate of human platelet aggregation as each other. Adenos...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1982.tb08781.x

    authors: Cusack NJ,Hourani SM

    更新日期:1982-02-01 00:00:00

  • Influence of epithelium on the inhibition of melittin-induced contraction of guinea-pig isolated trachea by the potassium channel opener NIP-121.

    abstract::1. We have investigated the effect of the potassium channel opener, NIP-121, on contraction elicited by melittin (a phospholipase A2 activator) in epithelium-intact and epithelium-denuded trachea isolated from guinea-pigs. The effects of NIP-121 were compared with those of isoprenaline, aminophylline and hydrocortison...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1993.tb13734.x

    authors: Shikada K,Tanaka S

    更新日期:1993-08-01 00:00:00

  • Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin.

    abstract::1. We compared the ability of rat amylin, rat calcitonin gene-related peptide (CGRP) and rat and salmon calcitonins to elevate cyclic AMP levels and to inhibit [U-14C]-glucose incorporation into glycogen in insulin-stimulated intact rat soleus muscle and in two cell lines derived from rodent skeletal muscle, L6 and C2...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1996.tb15270.x

    authors: Pittner RA,Wolfe-Lopez D,Young AA,Beaumont K

    更新日期:1996-03-01 00:00:00

  • Mechanism of suppression of insulin signalling with lignocaine.

    abstract::Lignocaine suppresses insulin-stimulated glucose transport into the cells and insulin-stimulated glycogenesis at doses equivalent to that used in the treatment of muscle pain disorder. We evaluated the direct effect of lignocaine on insulin receptor (IR) kinase activity. After lignocaine (40 mM, approximately equivale...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0704691

    authors: Hirose M,Martyn JA,Kuroda Y,Marunaka Y,Tanaka Y

    更新日期:2002-05-01 00:00:00

  • Effect of adenosine and some of its structural analogues on the conductance of NMDA receptor channels in a subset of rat neostriatal neurones.

    abstract::1. In order to investigate the modulatory effects of adenosine on excitatory amino acid projections onto striatal medium spiny neurons, whole-cell patch clamp experiments were carried out in rat brain slices. The effects of various agonists for P1 (adenosine) and P2 (ATP) purinoceptors and their antagonists were inves...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0701347

    authors: Nörenberg W,Wirkner K,Illes P

    更新日期:1997-09-01 00:00:00

  • Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis.

    abstract:BACKGROUND AND PURPOSE:Extrahepatic vasodilation and increased intrahepatic vascular resistance represent attractive targets for the medical treatment of portal hypertension in liver cirrhosis. In both dysfunctions, dysregulation of the contraction-mediating Rho kinase plays an important role as it contributes to alter...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.2009.00158.x

    authors: Hennenberg M,Trebicka J,Stark C,Kohistani AZ,Heller J,Sauerbruch T

    更新日期:2009-05-01 00:00:00

  • Effects of RP 67580, a tachykinin NK1 receptor antagonist, on a primary afferent-evoked response of ventral roots in the neonatal rat spinal cord.

    abstract::1. The pharmacological characteristics of RP 67580, a non-peptide tachykinin NK1 receptor antagonist, and its effects on a reflex response evoked by stimulation of primary afferent fibres, were examined in isolated neonatal spinal cord preparations of the rat. Potentials were recorded extracellularly from a lumbar ven...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1994.tb17116.x

    authors: Hosoki R,Yanagisawa M,Guo JZ,Yoshioka K,Maehara T,Otsuka M

    更新日期:1994-12-01 00:00:00

  • Effects of cholecystokinin and related peptides on neuronal activity in the ventromedial nucleus of the rat hypothalamus.

    abstract::1. An investigation into the effects of cholecystokinin octapeptide (CCK-8S) and its pentapeptide analogue, pentagastrin, on neurones located in ventromedial nuclei of rat hypothalamic slices maintained in vitro has been undertaken. 2. CCK-8S (0.01-1.0 microM) applied in the perfusion medium produced a concentration-d...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1988.tb11521.x

    authors: Boden P,Hill RG

    更新日期:1988-05-01 00:00:00

  • Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Nav 1.1 to Nav 1.7).

    abstract:BACKGROUND AND PURPOSE:The development of subtype-selective ligands to inhibit voltage-sensitive sodium channels (VSSCs) has been attempted with the aim of developing therapeutic compounds. Tetrodotoxin (TTX) is a toxin from pufferfish that strongly inhibits VSSCs. Many TTX analogues have been identified from marine an...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13985

    authors: Tsukamoto T,Chiba Y,Wakamori M,Yamada T,Tsunogae S,Cho Y,Sakakibara R,Imazu T,Tokoro S,Satake Y,Adachi M,Nishikawa T,Yotsu-Yamashita M,Konoki K

    更新日期:2017-11-01 00:00:00

  • Sodium-calcium exchanger contributes to membrane hyperpolarization of intact endothelial cells from rat aorta during acetylcholine stimulation.

    abstract::1. The role of sodium-calcium exchanger in acetylcholine (Ach)-induced hyperpolarization of intact endothelial cells was studied in excised rat aorta. The membrane potential was recorded using perforated patch-clamp technique. 2. The mean resting potential of endothelial cells was -44.1+/-1.4 mV. A selective inhibitor...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1038/sj.bjp.0705866

    authors: Bondarenko A

    更新日期:2004-09-01 00:00:00

  • Cardiac alpha 1-adrenoceptor densities in different mammalian species.

    abstract::1. alpha 1-Adrenoceptor densities were studied in cardiac membrane preparations from several mammalian species including human failing hearts under identical experiment conditions; the alpha 1-adrenoceptor antagonist, [3H]-prazosin, was used as radioligand. End-stage heart failure (NYHA IV) in human hearts was due to ...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1992.tb14484.x

    authors: Steinfath M,Chen YY,Lavický J,Magnussen O,Nose M,Rosswag S,Schmitz W,Scholz H

    更新日期:1992-09-01 00:00:00

  • CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.

    abstract:BACKGROUND AND PURPOSE:The chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and atherosclerosis. Consequently, antagonists of CXCR3 are of therapeutic interest. In this study, we set out to characterize binding sites of the specific low MW CXCR3 antagoni...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/bph.13027

    authors: Nedjai B,Viney JM,Li H,Hull C,Anderson CA,Horie T,Horuk R,Vaidehi N,Pease JE

    更新日期:2015-04-01 00:00:00

  • Mediterranean diet and health status: Active ingredients and pharmacological mechanisms.

    abstract::The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and exp...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bph.14778

    authors: Schwingshackl L,Morze J,Hoffmann G

    更新日期:2020-03-01 00:00:00

  • Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist.

    abstract::1. The alpha 2-adrenoceptor binding sites of rabbit spleen and rat kidney, labelled with [3H]-rauwolscine, were characterized using a range of subtype selective ligands. 2. In rabbit spleen, the alpha-2-adrenoceptor binding sites displayed high affinity for oxymetazoline and WB 4101 and low affinity for prazosin and c...

    journal_title:British journal of pharmacology

    pub_type: 杂志文章

    doi:10.1111/j.1476-5381.1990.tb12968.x

    authors: Michel AD,Loury DN,Whiting RL

    更新日期:1990-03-01 00:00:00