Abstract:
:1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induced responses. Likewise BW 755c (113 micro M) reversed the effect of indomethacin. 4. The results show that arachidonate lipoxygenase products may be responsible for the contractile responses seen in the presence of indomethacin.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Mitchell HWdoi
10.1111/j.1476-5381.1982.tb09250.xsubject
Has Abstractpub_date
1982-08-01 00:00:00pages
527-9issue
4eissn
0007-1188issn
1476-5381journal_volume
76pub_type
杂志文章abstract::1. Prostaglandins and the vasodilator neuropeptide, calcitonin-gene related peptide (CGRP), have both been implicated in the pathogenesis of migraine headache. We have used primary cultures of adult rat trigeminal neurones to examine the effects of prostanoids on CGRP release in vitro. 2. CGRP release was stimulated b...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0704357
更新日期:2001-11-01 00:00:00
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更新日期:1978-04-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:1981-04-01 00:00:00
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更新日期:2002-06-01 00:00:00
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更新日期:2000-01-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:1990-12-01 00:00:00
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