Abstract:
:Intracellular potentials were recorded from rabbit atria, cardiac Purkinje cells and papillary muscles before and after exposure to various concentrations of indecainide. The effects of aprindine also were studied in the atrial preparations. Both drugs depressed the maximum rate of depolarization (MRD) in a dose-related manner, indecainide being approximately ten times more potent than aprindine. Aprindine caused a dose-related bradycardia, but indecainide had no significant effect on sinus node frequency. Indecainide had a dose-related negatively inotropic effect in normal, half-normal and twice-normal extracellular calcium concentrations. Indecainide shortened action potential duration (APD) in atrium and Purkinje cells but prolonged APD to 50% repolarization in ventricular muscle. The actions of indecainide were extremely persistent. No significant recovery of MRD was observed after pauses in stimulation of up to 16 s. Indecainide had no effect on effective refractory period (ERP) measured by interpolated premature stimuli. Indecainide is therefore categorized as a Class 1c antiarrhythmic agent. The effects of both aprindine and indecainide on MRD were increased in hypoxic atria. Conduction velocity in hypoxic atria exposed to indecainide was greater than in controls, however, suggesting the possibility of improved cell-to-cell coupling.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Dennis PD,Vaughan Williams EMdoi
10.1111/j.1476-5381.1985.tb08825.xsubject
Has Abstractpub_date
1985-05-01 00:00:00pages
11-9issue
1eissn
0007-1188issn
1476-5381journal_volume
85pub_type
杂志文章abstract::1. Guinea-pig tracheal smooth muscle cells were isolated and maintained in culture for 14-21 days prior to the study of the effect of a selective bradykinin B1 agonist and B2 antagonists upon bradykinin-stimulated phospholipase C and D activities. 2. Bradykinin-stimulated phospholipase C activity was determined by mas...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1993.tb13835.x
更新日期:1993-09-01 00:00:00
abstract::1 Subcutaneous administration of glucagon (1 and 0.5 mg/kg) 30 min before the injection of carrageenin or dextran into the rat's paw reduced oedema and the local exudation of Evans blue previously given intravenously. 2 The effect persisted after removal of the adrenal medulla but not after adrenalectomy. 3 When gluca...
journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1975.tb07611.x
更新日期:1975-09-01 00:00:00
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journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1989.tb12668.x
更新日期:1989-12-01 00:00:00
abstract::1 The D3 dopamine receptor presumably activates Gi/Go subtypes of G-proteins, like the structurally analogous D2 receptor, but its signalling targets have not been clearly established due to weak functional signals from cloned receptors as heterologously expressed in mostly non-neuronal cell lines. 2 In this study, re...
journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1999-11-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:2014-12-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1038/sj.bjp.0701644
更新日期:1998-02-01 00:00:00
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更新日期:1995-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1988.tb11601.x
更新日期:1988-07-01 00:00:00
abstract::1. Transcriptional control of the human beta(2) adrenergic receptor gene (ADRB2) predominantly resides within a 549 base pair region immediately 5' to the start of translation. Within this region, four naturally occurring polymorphisms, -468 C-->G, -367 T-->C, -47 T-->C, and -20 T-->C, have been identified. 2. To dete...
journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1111/j.1476-5381.1995.tb13372.x
更新日期:1995-04-01 00:00:00
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journal_title:British journal of pharmacology
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更新日期:1997-04-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
doi:10.1111/j.1476-5381.1984.tb10102.x
更新日期:1984-03-01 00:00:00
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更新日期:1996-08-01 00:00:00
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更新日期:1991-11-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:1976-06-01 00:00:00
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更新日期:2000-06-01 00:00:00
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journal_title:British journal of pharmacology
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doi:10.1111/j.1476-5381.1970.tb10594.x
更新日期:1970-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Venoms are a rich source of ligands for ion channels, but very little is known about their capacity to modulate G-protein coupled receptor (GPCR) activity. We developed a strategy to identify novel toxins targeting GPCRs. EXPERIMENTAL APPROACH:We studied the interactions of mamba venom fractions...
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更新日期:2010-01-01 00:00:00
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更新日期:2001-09-01 00:00:00
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更新日期:1994-12-01 00:00:00
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更新日期:1996-07-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:1990-10-01 00:00:00
abstract::1. The effects of different K+ channel blockers were studied on nitric oxide (NO)-mediated non-adrenergic non-cholinergic (NANC) relaxations in the canine ileocolonic junction. 2. The non-selective blockers of K+ channels, 4-aminopyridine (4-AP) and tetraethylammonium (TEA) and the blocker of large conductance Ca(2+)-...
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pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:British journal of pharmacology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract::1. We examined how gamma-aminobutyric acid (GABA) influences interaction of picrotoxin and tert-butylbicyclophosphorothionate (TBPS) with recombinant rat alpha 1 beta 2 gamma 2 GABAA receptors stably expressed in human embryonic kidney cells (HEK293), as monitored with changes in Cl- currents measured by the whole-cel...
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doi:10.1111/j.1476-5381.1995.tb16368.x
更新日期:1995-06-01 00:00:00