Acute effects of a monoamine oxidase inhibitor, tranylcypromine, on thermoregulation in the conscious rabbit.

Abstract:

:1. The effect of a single injection of the monoamine oxidase inhibitor, tranylcypromine, administered intravenously (20 mg/kg) or into the lateral cerebral ventricle (5-10 mg), on hypothalamic and rectal temperature, has been investigated.2. Intravenous tranylcypromine causes a significant rise in body temperature, which is due, at least in part, to cutaneous vasoconstriction; this vasoconstriction is augmented by sympathectomy. It is concluded that this vasoconstrictor effect is not mediated via the central nervous system.3. Intraventricular tranylcypromine caused a transient but significant fall in core temperature. This is interpreted as being compatible with selective augmentation of hypothalamic levels of 5-hydroxytryptamine.

journal_name

Br J Pharmacol

authors

Cranston WI,Rosendorff C

doi

10.1111/j.1476-5381.1970.tb10594.x

subject

Has Abstract

pub_date

1970-05-01 00:00:00

pages

530-6

issue

3

eissn

0007-1188

issn

1476-5381

journal_volume

38

pub_type

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