Abstract:
:The mucin-type O-glycome in cancer aberrantly expresses the truncated glycans Tn (GalNAcα1-Ser/Thr) and STn (Neu5Acα2,6GalNAcα1-Ser/Thr). However, the role of Tn and STn in cancer and other diseases is not well understood. Our recent discovery of the self-binding properties (carbohydrate-carbohydrate interactions, CCIs) of Tn (Tn-Tn) and STn (STn-STn) provides a model for their possible roles in cellular transformation. We also review evidence that Tn and STn are members of a larger family of glycan tumor antigens that possess CCIs, which may participate in oncogenesis.
journal_name
Glycobiologyjournal_title
Glycobiologyauthors
Sletmoen M,Gerken TA,Stokke BT,Burchell J,Brewer CFdoi
10.1093/glycob/cwy032subject
Has Abstractpub_date
2018-07-01 00:00:00pages
437-442issue
7eissn
0959-6658issn
1460-2423pii
4959751journal_volume
28pub_type
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