Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2.

abstract：:The glycobiology of Schistosoma mansoni is dominated by developmentally regulated expression of various fucosylated structures, most notably the Lewis X epitope and a multifucosylated sequence, Fuc alpha1-->2Fuc alpha1-->, in its various forms. For the infective cercarial stage, Lewis X has been structurally identifie...

journal_title：Glycobiology

authors： Huang HH,Tsai PL,Khoo KH

更新日期：2001-05-01 00:00:00

abstract：:To study human alpha1,3/1,4fucosyltransferase (Fuc-TIII) as an alpha1,3 fucosyltransferase, we constructed two cell clones, C127-FT and C127-T-FT, by transfecting cDNA in parental (C127) or Polyoma T antigen expressing (C127-T) mouse cells, respectively. Both C127-FT and C127-T-FT clones express high levels of a fucos...

journal_title：Glycobiology

authors： Valli M,Bardoni A,Trinchera M

更新日期：1999-01-01 00:00:00

abstract：:N-acetylglucosaminyltransferase V, encoded by the Mgat5 gene, plays an important regulatory role in the synthesis of complex N-glycans, including the Lewis antigens. The elevated expression of this enzyme is regulated during development and is highly associated with cellular transformation and malignancy. In addition,...

journal_title：Glycobiology

authors： Alverez K,Haswell C,St Clair M,Perng GS,Shorebah M,Pierce M,Fregien N

更新日期：2002-07-01 00:00:00

abstract：:Sulfated O-linked oligosaccharides from the sea urchin egg receptor have been shown to bind to acrosome-reacted sperm and to inhibit fertilization in a competitive bioassay. However, the inhibitory activity of these isolated chains was much lower than that of a recombinant protein representing a portion of the extrace...

journal_title：Glycobiology

authors： Dhume ST,Stears RL,Lennarz WJ

更新日期：1996-01-01 00:00:00

abstract：:An ultrasensitive method for analysis of polysialic acid (polySia) chains, using fluorescence-assisted high-performance liquid chromatography was developed. The new method is a substantial improvement of our earlier method in which the reducing terminal Sia residues of a homologous series of oligo/polySia hydrolytical...

journal_title：Glycobiology

authors： Inoue S,Lin SL,Lee YC,Inoue Y

更新日期：2001-09-01 00:00:00

abstract：:Multivalency in lectins is a phenomenon that has been discussed at considerable length. The structural basis for the role of multivalency in garlic lectin has been investigated here through computational studies. Biochemical studies have shown that the binding affinity of garlic lectin for high mannose oligosaccharide...

journal_title：Glycobiology

authors： Ramachandraiah G,Chandra NR,Surolia A,Vijayan M

更新日期：2003-11-01 00:00:00

abstract：:The structure of the complex mixture of the core oligosaccharide components of the lipooligosaccharide (LOS) fraction of Agrobacterium tumefaciens strain TT111 was determined directly on the deacetylated products by means of spectroscopical methods. The rhamnan oligosaccharide elongating the inner Kdo residue shares s...

journal_title：Glycobiology

authors： De Castro C,Carannante A,Lanzetta R,Liparoti V,Molinaro A,Parrilli M

更新日期：2006-12-01 00:00:00

abstract：:The transplantation of organs from lower animals such as pigs into humans is prevented by a severe rejection reaction initiated by complement fixing xenoreactive natural antibodies. Most anti-pig xenoreactive natural antibodies in humans are thought to recognize Gal alpha 1-3Gal beta 1-4GlcNAc and are also thought to ...

journal_title：Glycobiology

authors： Parker W,Lateef J,Everett ML,Platt JL

更新日期：1996-07-01 00:00:00

abstract：:Mechanisms for nonenzymatic protein glycation have been extensively studied albeit with an emphasis at the later stages that gives rise to advanced glycation end products. No detailed investigation of the initial, noncovalent binding of d-glucose to human hemoglobin A (HbA) exists in the literature. Although anionic m...

journal_title：Glycobiology

authors： Clark SL,Santin AE,Bryant PA,Holman R,Rodnick KJ

更新日期：2013-11-01 00:00:00

abstract：:Mac-2 is a member of the S-(soluble) lectin family. Its identification and isolation from a wide variety of cell types and tissues suggest a diversity of roles in various biological systems. The key points to be made are that Mac-2, and the S-lectins in general, by virtue of their recognition of a variety of carbohydr...

journal_title：Glycobiology

authors： Hughes RC

更新日期：1994-02-01 00:00:00

abstract：:We have characterized a glycosphingolipid (GSL) receptor for Staphylococcus enterotoxin-B (SEB) in cultured human kidney proximal tubular (PT) cells. Solid-phase binding of [125I]SEB to the GSL receptor was concentration dependent and was not displaceable by two structurally related toxins, such as staphylococcal ente...

journal_title：Glycobiology

authors： Chatterjee S,Khullar M,Shi WY

更新日期：1995-05-01 00:00:00

abstract：:β-Glucans possess broad immunomodulatory properties, including activation of innate immune functions such as oxidative burst activity. The differential roles of complement receptor type 3 (CR3) and Dectin-1, the known β-glucan receptors, and their associated signaling pathways in the generation of oxidative burst indu...

journal_title：Glycobiology

authors： Bose N,Wurst LR,Chan AS,Dudney CM,LeRoux ML,Danielson ME,Will PM,Nodland SE,Patchen ML,Dalle Lucca JJ,Lebeda FJ,Vasilakos JP

更新日期：2014-04-01 00:00:00

abstract：:Rabies glycoprotein (RGP(WT)) contains N-glycosylation sequons at Asn(37), Asn(247), and Asn(319), although Asn(37) is not efficiently glycosylated. To examine N-glycan processing at Asn(247) and Asn(319), full-length glycosylation mutants, RGP(-2-) and RGP(--3), were expressed, and Endo H sensitivity was compared. Wh...

journal_title：Glycobiology

authors： Wojczyk BS,Takahashi N,Levy MT,Andrews DW,Abrams WR,Wunner WH,Spitalnik SL

更新日期：2005-06-01 00:00:00

abstract：:Influenza C virus spike glycoprotein HEF specifically recognizes glycoconjugates containing 9-O-acetyl-N-acetylneuraminic acid. The same protein also contains an esterase activity. Taking advantage of these two properties, influenza C virus was used as a very sensitive probe for the detection of traces of 9-O-acetyl-N...

journal_title：Glycobiology

authors： Zimmer G,Suguri T,Reuter G,Yu RK,Schauer R,Herrler G

更新日期：1994-06-01 00:00:00

abstract：:N-Acetylglucosaminlyltransferase-V (GnT-V) synthesizes GlcNAcbeta1,6Man branched N-glycans both in vitro and in vivo. A paralog, GnT-Vb (or GnT-IX), has also been shown to synthesize both GlcNAcbeta1,6Man branched N- and O-glycans. GnT-V is expressed in most human and rodent tissues while GnT-Vb expression is limited ...

journal_title：Glycobiology

authors： Alvarez-Manilla G,Troupe K,Fleming M,Martinez-Uribe E,Pierce M

更新日期：2010-02-01 00:00:00

abstract：:The glycobiology of the cestodes, a class of parasitic flatworms, is still largely unexplored. An important cestode species is Echinococcus granulosus, the tissue-dwelling larval stage of which causes hydatid disease. The E. granulosus larva is protected from the host by a massive mucin-based extracellular matrix term...

journal_title：Glycobiology

authors： Lin G,Todeschini AR,Koizumi A,Neves JL,González H,Dematteis S,Hada N,Previato JO,Ferreira F,Mendonça-Previato L,Díaz A

更新日期：2013-04-01 00:00:00

abstract：:The leguminous-type (L-type) lectin ER-Golgi intermediate compartment (ERGIC)-53, a homo-oligomeric endoplasmic reticulum (ER)-Golgi recycling protein, functions as a transport receptor for newly synthesized glycoproteins in the early secretory pathway. Although a limited subset of cargo glycoproteins transported by E...

journal_title：Glycobiology

authors： Chen Y,Hojo S,Matsumoto N,Yamamoto K

更新日期：2013-07-01 00:00:00

abstract：:Lens culinaris lectin (LCA) is a useful probe for the detection in serum of a core-fucosylated alpha-fetoprotein, called AFP-L3 fraction, which is a well-known marker for the diagnosis and prognosis of hepatocellular carcinoma. Here we performed a systematic quantitative interaction analysis of LCA and its close homol...

journal_title：Glycobiology

authors： Tateno H,Nakamura-Tsuruta S,Hirabayashi J

更新日期：2009-05-01 00:00:00

abstract：:Cryptococcus neoformans, an opportunistic fungal pathogen, produces a glycan capsule to evade the immune system during infection. This definitive virulence factor is composed mainly of complex polysaccharides, which are made in the secretory pathway by reactions that utilize activated nucleotide sugar precursors. Alth...

journal_title：Glycobiology

authors： Li LX,Ashikov A,Liu H,Griffith CL,Bakker H,Doering TL

更新日期：2017-01-01 00:00:00

abstract：:Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine to generate 3-O-sulfated heparan sulfate (HS), which is a rare component in HS from natural sources. We previously reported that 3-O- sulfotransferase isoform 5 (3-OST-5) generates both an antithrombin-binding site to exhibit ...

journal_title：Glycobiology

authors： Chen J,Duncan MB,Carrick K,Pope RM,Liu J

更新日期：2003-11-01 00:00:00

abstract：:Polypeptide GalNAc-transferases (GalNAc-Ts) constitute a family of 20 human glycosyltransferases (comprising 9 subfamilies), which initiate mucin-type O-glycosylation. The O-glycoproteome is thought to be differentially regulated via the different substrate specificities and expression patterns of each GalNAc-T isofor...

journal_title：Glycobiology

authors： Festari MF,Trajtenberg F,Berois N,Pantano S,Revoredo L,Kong Y,Solari-Saquieres P,Narimatsu Y,Freire T,Bay S,Robello C,Bénard J,Gerken TA,Clausen H,Osinaga E

更新日期：2017-01-01 00:00:00

abstract：:Sialic acid has long been considered to be the sole receptor for influenza virus. The viral hemagglutinin (HA) is known to bind cell surface sialic acid, and sialic acids on viral glyco-proteins are cleaved by the viral neuraminidase (NA) to promote efficient release of progeny virus particles. However, NWS-Mvi, a mut...

journal_title：Glycobiology

authors： Stray SJ,Cummings RD,Air GM

更新日期：2000-07-01 00:00:00

abstract：:Galectins are a sub-family of lectins, defined by their highly conserved beta-sandwich structures and ability to bind to beta-galactosides, like Gal beta1-4 Glc (lactose). Here, we used (15)N-(1)H HSQC and pulse field gradient (PFG) NMR spectroscopy to demonstrate that galectin-1 (gal-1) binds to the relatively large ...

journal_title：Glycobiology

authors： Miller MC,Klyosov A,Mayo KH

更新日期：2009-09-01 00:00:00

abstract：:The catabolism of dermatan sulfate (DS) commences with endohydrolysis of the polysaccharide to oligosaccharides by proposed endo-beta-N-acetylhexosaminidase and endohexuronidase activities. To investigate the substrate specificities of these activities, we developed an assay to measure specific products of their actio...

journal_title：Glycobiology

authors： Nielsen TC,Meikle PJ,Hopwood JJ,Fuller M

更新日期：2008-12-01 00:00:00

abstract：:The substrate specificity of an alpha2,3-sialyltransferase (v-ST3Gal I) obtained from myxoma virus infected RK13 cells has been determined. Like mammalian sialyltransferase enzymes, the viral enzyme contains the characteristic L- and S-sialyl motif sequences in its catalytic domain. Analysis of the deduced amino acid ...

journal_title：Glycobiology

authors： Sujino K,Jackson RJ,Chan NW,Tsuji S,Palcic MM

更新日期：2000-03-01 00:00:00

abstract：:Glycation of immunoglobulin G (IgG) can result from incubation with a reducing sugar in vitro or during circulation in vivo. Upon injection of a recombinantly produced human therapeutic IgG into humans, changes in the glycation levels could be observed as a function of circulation time. Mass changes on the individual ...

journal_title：Glycobiology

authors： Goetze AM,Liu YD,Arroll T,Chu L,Flynn GC

更新日期：2012-02-01 00:00:00

abstract：:Differences in the fertilization behavior of Xenopus borealis from X. laevis and X. tropicalis suggest differences in the glycosylation of the egg jellies. To test this assumption, O-linked glycans were chemically released from the egg jelly coat glycoproteins of X. borealis. Over 50 major neutral glycans were observe...

journal_title：Glycobiology

authors： Li B,Russell SC,Zhang J,Hedrick JL,Lebrilla CB

更新日期：2011-07-01 00:00:00

abstract：:The Neu1 locus, in the S region of the murine histocompatibility-2 complex, regulates the sialic acid content of several liver lysosomal enzymes. Three alleles, Neu1a, Neu1b, and Neu1c, have been described on the basis of differential sialylation of the enzyme liver acid phosphatase. The Neu1a allele occurs in a small...

journal_title：Glycobiology

authors： Carrillo MB,Milner CM,Ball ST,Snoek M,Campbell RD

更新日期：1997-10-01 00:00:00

abstract：:The gut microbiota plays a major role in human health and an alteration in gut microbiota structure and function has been implicated in several diseases. In the colon, mucus covering the epithelium is critical to maintain a homeostatic relationship with the gut microbiota by harbouring a microbial community at safe di...

journal_title：Glycobiology

authors： Bell A,Juge N

更新日期：2020-10-09 00:00:00

abstract：:There is increasing evidence that secretory fluids such as tears, saliva and milk play an important role in protecting the human body from infection via a washing mechanism involving glycan-mediated adhesion of potential pathogens to secretory glycoproteins. Interaction of sweat with bacteria is well established as th...

journal_title：Glycobiology

authors： Peterson RA,Gueniche A,Adam de Beaumais S,Breton L,Dalko-Csiba M,Packer NH

更新日期：2016-03-01 00:00:00