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Arm-specific telomere dynamics of each individual chromosome in induced pluripotent stem cells revealed by quantitative fluorescence in situ hybridization.

Abstract：

:We have reported that telomere fluorescence units (TFUs) of established induced pluripotent stem cells (iPSCs) derived from human amnion (hAM933) and fetal lung fibroblasts (MRC-5) were significantly longer than those of the parental cells, and that the telomere extension rates varied quite significantly among clones without chromosomal instability, although the telomeres of other iPSCs derived from MRC-5 became shorter as the number of passages increased along with chromosomal abnormalities from an early stage. In the present study we attempted to clarify telomere dynamics in each individual chromosomal arm of parental cells and their derived clonal human iPSCs at different numbers of passages using quantitative fluorescence in situ hybridization (Q-FISH). Although no specific arm of any particular chromosome appeared to be consistently shorter or longer than most of the other chromosomes in any of the cell strains, telomere elongation in each chromosome of an iPSC appeared to be random and stochastic. However, in terms of the whole genome of any specific cell, the telomeres showed overall elongation associated with iPSC generation. We have thus demonstrated the specific telomere dynamics of each individual chromosomal arm in iPSCs derived from parental cells, and in the parental cells themselves, using Q-FISH.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Terai M,Izumiyama-Shimomura N,Aida J,Ishikawa N,Kuroiwa M,Arai T,Toyoda M,Nakamura K,Takubo K

doi

10.1016/j.tice.2014.08.005

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

470-6

issue

6

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(14)00074-3

journal_volume

46

pub_type

杂志文章

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