Abstract:
:The alpha, beta, and gamma subunits of the receptor with high affinity for immunoglobulin E were isolated and their compositions assessed by direct amino acid analysis and by incorporation of radioactive precursors. The compositions show no unusual features other than a rather high content of tryptophan in the alpha chain as assessed from the incorporation studies. The results combined with future sequence data will permit unambiguous determination of the multiplicity of the chains in the receptor. Chymotryptic peptide maps of the extrinsically iodinated subunits show several similar peptides, particularly for alpha and beta. However, these putative homologies were not apparent when tryptic maps of the biosynthetically ([3H]leucine) labeled subunits were analyzed.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Alcaraz G,Kinet JP,Liu TY,Metzger Hdoi
10.1021/bi00383a024subject
Has Abstractpub_date
1987-05-05 00:00:00pages
2569-75issue
9eissn
0006-2960issn
1520-4995journal_volume
26pub_type
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