Abstract：
:The effects of combined intravenous and intracoronary streptokinase without (Group I, n = 103) or with (Group II, n = 103) immediate coronary angioplasty were evaluated during a long-term (3 year) follow-up of 206 patients with acute transmural myocardial infarction. There were no baseline differences between the groups with regard to gender, age, infarct location, serum creatine kinase levels, time between onset of symptoms and treatment and coronary artery patency rate. Angioplasty was performed with a success rate of 69% and a reocclusion rate of 2%. Elective angioplasty was performed in 22 (21%) of 103 patients in Group I and 9 (9%) of 103 patients in Group II, with a success rate of 86% and 100%, respectively, reflecting the higher incidence of angina pectoris and antianginal therapy in Group I. Coronary bypass surgery was performed in 21 (20%) of 103 patients in Group I and 20 (19%) of 103 patients in Group II; there was one operative death in each group. During follow-up, coronary reocclusion or reinfarction, or both, occurred in 25 (29%) of 87 patients in Group I and in 16 (18%) of 87 patients in Group II with reperfused vessels (p = NS). Heart failure occurred in 40% of the patients in both groups who had increased end-diastolic and end-systolic volumes. The survival rate after 3 years was 78% in Group I and 80% in Group II (p = NS). Thus, long-term follow-up of patients with acute transmural infarction treated with and without immediate angioplasty does not demonstrate any difference with regard to clinical outcome and mortality.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Erbel R,Pop T,Diefenbach C,Meyer Jdoi
10.1016/0735-1097(89)90173-3subject
Has Abstractpub_date
1989-08-01 00:00:00pages
276-85; discussion 286-8issue
2eissn
0735-1097issn
1558-3597pii
0735-1097(89)90173-3journal_volume
14pub_type
临床试验,杂志文章abstract：OBJECTIVES:We studied the hypothesis that in the absence of vascular pathology, coronary artery vasospasm occurs as a result of local regions of vascular muscle hyperreactivity. We aimed to explore the basis for a functional etiology of those vasospasms not explained on a structural basis. BACKGROUND:Ovariectomized rh...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(96)00524-4
更新日期：1997-03-01 00:00:00
abstract：:In an attempt to determine whether mural thrombus in a dilated left ventricle is associated with specific flow patterns, a study was undertaken to assess qualitatively and quantitatively the flow characteristics by conventional pulsed and two-dimensional Doppler color flow examination. Forty patients with cardiomyopat...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(89)90230-1
更新日期：1989-03-15 00:00:00
abstract：OBJECTIVES:We sought to develop a high-yield canine model of sudden cardiac death (SCD). BACKGROUND:Because electrical stimulation is a powerful means to elicit nerve sprouting, we hypothesize that subthreshold electrical stimulation is more effective than nerve growth factor (NGF) infusion in inducing nerve sprouting...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2003.07.053
更新日期：2004-03-03 00:00:00
abstract：OBJECTIVES:We report the data from the Italian Survey on trans-septal catheterization (TSP-C) for catheter ablation of arrhythmias in the left heart that covered 2003 and previous years. BACKGROUND:Over the last decade the use of TSP-C in the electrophysiology laboratory has greatly increased. Recent data on number of...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jacc.2005.10.046
更新日期：2006-03-07 00:00:00
abstract：:In advanced heart failure, mitral regurgitation increases the burden of the failing ventricle and decreases effective stroke volume. Although tailored afterload reduction decreases mitral regurgitation at rest, it is not known if this benefit is maintained during upright exercise. Simultaneous radionuclide ventriculog...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90196-v
更新日期：1990-01-01 00:00:00
abstract：:In a multicenter study, 390 patients with sustained symptomatic ventricular tachycardia or ventricular fibrillation late after acute myocardial infarction were prospectively followed up to assess determinants of mortality and recurrence of arrhythmic events. Patients were given standard antiarrhythmic treatment, which...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0735-1097(90)90336-n
更新日期：1990-09-01 00:00:00
abstract：:Low osmolar contrast agents produce less adverse electrophysiologic and hemodynamic alterations during cardiac catheterization. The nonionic agents probably reduce the risk of provoking myocardial ischemia during coronary arteriography or ventriculography. Patients also report less subjective sensation of discomfort d...
journal_title：Journal of the American College of Cardiology
pub_type： 指南,杂志文章
doi：10.1016/0735-1097(93)90747-o
更新日期：1993-01-01 00:00:00
abstract：:The adequacy of two-dimensional echocardiography during right atrial pacing for the detection and characterization of coronary artery stenosis was examined in 10 closed chest dogs. Pacing at successively higher rates up to 210 beats/min was carried out in the control state and again during a 70% left anterior descendi...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(83)80309-x
更新日期：1983-10-01 00:00:00
abstract：:Antiarrhythmic drugs prolong the effective refractory period and depress conduction. To determine the exact role played by these two electrophysiologic effects in the termination of reentry, the effects of disopyramide, flecainide, propafenone and E-4031, a new class III drug, were examined in a canine model of atrial...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(91)90773-3
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to determine whether QRS duration (QRSd) correlates with occurrence of ventricular arrhythmia in patients with coronary disease (CAD) receiving implantable cardioverter-defibrillators (ICDs). BACKGROUND:A QRSd measured on a standard electrocardiograph (ECG) correlates with total mo...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2005.03.060
更新日期：2005-07-19 00:00:00
abstract：:The current study determined the effectiveness of nicardipine, a 1,4-dihydropyridine calcium antagonist, in preserving reperfused myocardium in a cat model of temporary coronary occlusion and ascertained if replenishment of myocardial phosphate stores during reperfusion as defined by phosphorus-31 nuclear magnetic res...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(90)90328-m
更新日期：1990-12-01 00:00:00
abstract：OBJECTIVES:This study investigates whether repeat coronary interventions, applied over an extended time period, can successfully curtail the progression of ischemic symptoms and angiographic lumen narrowing. BACKGROUND:Coronary artery disease is a chronic and generally progressive disorder, and potential treatment str...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(96)00002-2
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVES:We sought to identify age-related differences in the ventricular response of patients after bidirectional cavopulmonary anastomosis (CPA) and to compare changes in the ventricular response among children < 3 years of age who underwent CPA with that of age-matched control subjects who had a systemic to pulmon...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/S0735-1097(96)00300-2
更新日期：1996-11-01 00:00:00
abstract：:Atrial fibrillation is the most common sustained cardiac arrhythmia encountered in clinical practice. Atrial fibrillation increases with age and is relatively common (> 5%) in patients > 69 years old. Despite this, our understanding of the underlying electrophysiologic mechanisms and the optimal management remains inc...
journal_title：Journal of the American College of Cardiology
pub_type：
doi：
更新日期：1993-12-01 00:00:00
abstract：OBJECTIVES:Parenteral L-arginine will improve myocardial ischemia in patients with obstructive coronary artery disease. BACKGROUND:Endothelial dysfunction causes coronary arterial constriction during stress, and L-arginine improves endothelial dysfunction. METHODS:Twenty-two patients with stable coronary artery disea...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0735-1097(98)00323-4
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:Arterial 18fluorodeoxyglucose (FDG) positron emission tomography (PET) is considered a measure of atherosclerotic plaque macrophages and is used for quantification of disease activity in clinical trials, but the distribution profile of FDG across macrophages and other arterial cells has not been fully clarif...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2019.06.057
更新日期：2019-09-03 00:00:00
abstract：:Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular dru...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2015.07.018
更新日期：2015-09-15 00:00:00
abstract：OBJECTIVES:This study prospectively evaluated whether early assessment with adenosine thallium-201 tomography could better refine risk stratification on the basis of absolute extent of myocardial ischemia in postinfarction patients in clinically stable condition. BACKGROUND:Postinfarction patients are at increased ris...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(95)00016-W
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVES:We tested the hypothesis of whether an inhibition of the nitroglycerin (GTN) bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) contributes to GTN tolerance in human blood vessels. BACKGROUND:The hemodynamic effects of GTN are rapidly blunted by the development of tolerance, a phenomenon ass...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2007.08.031
更新日期：2007-12-04 00:00:00
abstract：:Patients with portal hypertension of varying etiology may develop pulmonary artery hypertension. In the present autopsy study, pulmonary and hepatic tissue was studied in 12 patients in whom pulmonary and portal hypertension coexisted. Plexogenic pulmonary arteriopathy was present in 10 patients, 7 of whom had coexist...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(87)80123-7
更新日期：1987-12-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to examine the effect of PCSK9 R46L on low-density lipoprotein cholesterol (LDL-C), risk of ischemic heart disease (IHD), and mortality. BACKGROUND:The 46L allele has been associated with reductions in LDL-C and risk of IHD, but results vary between studies. METHODS:We determined ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jacc.2010.02.044
更新日期：2010-06-22 00:00:00
abstract：BACKGROUND:Routine apolipoprotein (apo) measurements for cardiovascular disease (CVD) are restricted to apoA-I and apoB. Here, the authors measured an unprecedented range of apolipoproteins in a prospective, population-based study and relate their plasma levels to risk of CVD. OBJECTIVES:This study sought to measure a...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2016.11.065
更新日期：2017-02-21 00:00:00
abstract：:Nonionic contrast media are suggested to cause increased thromboembolism (in vivo), platelet aggregation and procoagulant effect (in vitro) as compared with ionic contrast media. To study these effects in vivo, 30 consecutive patients undergoing routine angiography were prospectively randomized to three groups of 10 p...
journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0735-1097(91)90643-n
更新日期：1991-06-01 00:00:00
abstract：:Six patients with coexistent Mahaim and Kent accessory connections are described. Two had left nodoventricular Mahaim connections, the first reported cases demonstrating these findings. In neither were the left-sided Mahaim connections components of a tachycardia and their presence was incidental. In two of four with ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(87)80020-7
更新日期：1987-08-01 00:00:00
abstract：:To be of clinical value in the treatment of heart failure, a drug must permit patients either to feel better or to live longer, or both. Yet, because the assessment of both quality and quantity of life is difficult, many investigators have proposed using alternate measures (namely, surrogate end points) that may indic...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(93)90487-l
更新日期：1993-10-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND:Although drug-eluting stent (DES) implantation in diabetic patients is common practice, pivotal randomized trials enrolled <2,500 diabetic...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jacc.2012.08.993
更新日期：2012-12-04 00:00:00
abstract：:High technology interventions near the end of life exact a high cost both in human and economic terms. Breathtaking advances in cardiology have helped to prolong life and improve its quality for many. For some, it has transformed the process of dying into a medical nightmare. The "do everything possible" attitude that...
journal_title：Journal of the American College of Cardiology
pub_type： 社论
doi：10.1016/s0735-1097(96)00341-5
更新日期：1996-11-15 00:00:00
abstract：:Kawasaki disease (KD) is an acute, self-limited vasculitis that typically occurs in young children and was first described by Japanese pediatrician Tomisaku Kawasaki in 1967. Although originally thought to be a rare condition, KD has become the most common cause of acquired heart disease in the pediatric age group in ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2009.04.102
更新日期：2009-11-17 00:00:00
abstract：OBJECTIVES:We studied the expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and endothelial selectin (E-selectin) on aortic valve endothelium in patients undergoing valve replacement. We also assessed the relation between serum levels and endothelial expression and als...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(00)00998-0
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Autosomal recessive hypercholesterolemia (ARH) is a rare lipid disorder characterized by premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data for clinical management and cardiovascular outcomes in ARH. OBJECTIVES:Evaluation of changes in lipid management, achievement of low-densit...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/j.jacc.2017.11.028
更新日期：2018-01-23 00:00:00
