Abstract：
:The concentration of myometrial and decidual oxytocin receptors increases dramatically in normal women in late pregnancy, causing enhanced uterine sensitivity to physiologic levels of oxytocin. Similar increase in myometrial oxytocin receptors has been found in women in preterm labor, indicating a role for oxytocin also in idiopathic preterm labor. A newly synthesized oxytocin analogue, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, has been found to be a competitive inhibitor of oxytocin. The present study was conducted to test its efficacy in suppressing uterine contractions during preterm labor in women. Twelve patients with established, uncomplicated preterm labor between 27 and 33 weeks of gestational age were given intravenous infusions of the analogue for 1.5 to 13 hours during continuous external cardiotocographic monitoring. In nine patients inhibition of uterine contractions was achieved and further progression in cervical scores was arrested. In three patients, all at 27 weeks of gestational age, no significant tocolytic effect was observed during a 1.5-hour infusion of the analogue and the patients were then given ritodrine intravenously. No side effects were observed in any of the patients. These preliminary findings support the concept that an increased concentration of uterine oxytocin receptors is an important etiologic factor in uncomplicated preterm labor and therefore oxytocin receptor blockade may be a therapeutic alternative for this condition.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Andersen LF,Lyndrup J,Akerlund M,Melin Pdoi
10.1055/s-2007-999575subject
Has Abstractpub_date
1989-04-01 00:00:00pages
196-9issue
2eissn
0735-1631issn
1098-8785journal_volume
6pub_type
临床试验,杂志文章abstract：OBJECTIVE:To determine epidemiology and clinical characteristics of infants with methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA) in a level III neonatal intensive care unit (NICU). STUDY DESIGN:All NICU admissions (2001 to 2008) with any positive S. aureus culture were included as cases. Cas...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1304819
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE: This study aimed to determine if delayed cord clamping (DCC) affected brain myelin water volume fraction (VFm) and neurodevelopment in term infants. STUDY DESIGN: This was a single-blinded randomized controlled trial of healthy pregnant women with term singleton fetuses randomized at birth to either immedia...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1714258
更新日期：2020-07-21 00:00:00
abstract：OBJECTIVE:Fetal tachyarrhythmias complicate 0.5% of pregnancies, with high morbidity and mortality. We hypothesized that maternal factors may predispose to fetal supraventricular tachycardia (SVT). STUDY DESIGN:We reviewed medical records of all 124 mothers who presented to the Vanderbilt Fetal Cardiology Clinic from ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0035-1552942
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the association between midpregnancy cervical length and postterm delivery and cesarean delivery during labor. STUDY DESIGN:In a multicenter cohort study, cervical length was measured in low-risk singleton pregnancies between 16 and 22 weeks of gestation. From this cohort, we identified nulliparo...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究
doi：10.1055/s-0035-1556067
更新日期：2016-01-01 00:00:00
abstract：:A randomized clinical trial (RCT) noted that sonographic examination in the third trimester, in conjunction with delivery at term for abnormalities of fetal growth, significantly decreased the likelihood of small-for-gestational-age (SGA) neonates in uncomplicated pregnancies. We identified 15 characteristics of scree...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1321497
更新日期：2013-01-01 00:00:00
abstract：:To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2000-13437
更新日期：2000-01-01 00:00:00
abstract：:Previous work has shown that fetal hydrographic magnetic resonance imaging (MRI) provided additional information complementary to T2-weighted single-shot fast spin echo (ssFSE) images. The objective of this study was to determine if hydrographic MRI provides better conspicuity of fetal eye structures compared with ssF...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0031-1295636
更新日期：2012-04-01 00:00:00
abstract：:This report describes 40 consecutive emergency cerclages on dilated and effaced cervices prior to 26 weeks' gestation. These "emergency" cerclages were associated with a mean extension of gestational age of 12 weeks (range, 3 days to 20.5 weeks). Thirty-one of 40 pregnancies were carried to 28 weeks' gestation and 23 ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999307
更新日期：1992-05-01 00:00:00
abstract：:The objective of this paper is to evaluate the efficacy of various magnetic resonance imaging (MRI) sequences and the general usefulness of prenatal MRI in determining the position of the fetal liver and visualizing lung tissue in fetuses who have congenital diaphragmatic hernia (CDH). This was a retrospective review ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-1999-6821
更新日期：1999-01-01 00:00:00
abstract：:The aim of this study was to compare the pregnancy outcome and delivery complications in women 40 years or older (cases) to that of women 20 to 30 years old (controls). Over a 5-year period, 319 cases had a singleton delivery in our institution. These women were compared with 326 controls. Parity was significantly hig...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2002-20175
更新日期：2002-01-01 00:00:00
abstract：:Diagnosis of fetal pulmonary hypoplasia could be of great benefit to the obstetrician in the management of those pregnancies complicated by prolonged preterm ruptured membranes. Ultrasonography and magnetic resonance imaging were employed for fetal diagnosis of pulmonary hypoplasia and we were unable to predict accura...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-994689
更新日期：1993-01-01 00:00:00
abstract：:It is well established that ultrasound measurement of femur length and biparietal diameter are comparably accurate estimators of gestational age when obtained in the first half of pregnancy. Both estimators, however, become less accurate later in pregnancy. The present study compares the relative accuracy of these est...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999837
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:This study was aimed to evaluate the prevalence of sonographic markers for placenta accreta spectrum (PAS) in pregnancies at low-risk for PAS. STUDY DESIGN:Pregnant women at low-risk for PAS presenting for routine second trimester ultrasound who enrolled in the study were evaluated prospectively for sonograp...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1676488
更新日期：2019-07-01 00:00:00
abstract：:The purpose of this study was to determine if placental abruption or previa in women with a history of a prior cesarean delivery (CD) can be predicted. A retrospective cohort study of pregnant women with previous CD was conducted in 17 centers between 1996 and 2000. Women developing placenta previa or abruption in the...
journal_title：American journal of perinatology
pub_type： 杂志文章,多中心研究
doi：10.1055/s-2007-981430
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To evaluate if fundal (F) dominance of the electrohysterogram is associated with vaginal delivery and lack of F dominance is associated with cesarean for labor dystocia. STUDY DESIGN:We conducted a prospective cohort study of nulliparous women in spontaneous labor at ≥36 weeks. Clinicians were blinded to ele...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1675621
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE: The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if <4 hours of TST is sufficient for accurate interpretation. STUDY DESIGN: Overall, 242 PSGs performed in 194 infants <6 months of chronological age between March 2013 and December...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0040-1718948
更新日期：2020-10-27 00:00:00
abstract：:Rotavirus is the most common nonseasonal vaccine preventable illness. Despite increased severity of rotaviral illness in early infancy, most neonatal intensive care units (NICU) do not administer rotavirus vaccination either during the NICU stay at age of eligibility or at discharge as the Advisory Committee on Immuni...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0038-1660463
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:This study aimed to describe the experience with a protocol of therapeutic hypothermia (TH) in southern Brazil. STUDY DESIGN:Newborns with gestational age > 35 weeks with evidence of perinatal asphyxia plus moderate or severe encephalopathy were recruited between March 2011 and November 2017. Whole-body hypo...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0039-1692388
更新日期：2020-07-01 00:00:00
abstract：:Anti-Cw is an uncommon cause of clinically significant hemolytic disease of the newborn (HDN). We report an unusually severe case of HDN due to anti-Cw that required phototherapy and exchange transfusion. We also describe a novel PCR-RFLP method for Cw typing of fetal genomic DNA that was used for prenatal diagnosis i...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-993872
更新日期：1999-01-01 00:00:00
abstract：:Infection-related neonatal mortality due to omphalitis in developing country home births is an important public health problem. Three cluster randomized trials of 4% chlorhexidine applied to the umbilical cord stump from once to multiple times in the days following a home birth have evaluated this intervention compare...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0032-1329695
更新日期：2013-09-01 00:00:00
abstract：:The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participate; 48 mothers declined entry. Before delivery, pharmacy randomize...
journal_title：American journal of perinatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1055/s-2007-993836
更新日期：1999-01-01 00:00:00
abstract：AIMS:Detection and careful stratification of fetal heart rate (FHR) is extremely important in all pregnancies. The most lethal cardiac rhythm disturbances occur during apparently normal pregnancies where FHR and rhythm are regular and within normal or low-normal ranges. These hidden depolarization and repolarization ab...
journal_title：American journal of perinatology
pub_type： 杂志文章,评审
doi：10.1055/s-0034-1372430
更新日期：2014-08-01 00:00:00
abstract：:Pleural effusion is not an uncommon complication of percutaneous intravenous catheters in neonates. Umbilical venous catheters (UVCs) are associated with pleural effusion following abnormal placement in the left atrium or pulmonary veins due to venous obstruction. We report for the first time a case of right-sided ple...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-992174
更新日期：2007-11-01 00:00:00
abstract：:Four hundred sixty-four fetuses underwent real time ultrasound examination within 72 hours before birth to evaluate other factors than the weight formula itself that might influence the accuracy of ultrasound weight estimation. The results indicated that fetal sex had no effect on weight estimation accuracy, but that ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999866
更新日期：1986-07-01 00:00:00
abstract：OBJECTIVE:To evaluate the interobserver reliability of fetal heart rate (FHR) pattern definition and interpretation assessed by physicians at various levels of training using standard Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) definitions and standard principles of interpret...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0032-1326991
更新日期：2013-06-01 00:00:00
abstract：OBJECTIVE:This study assessed the impact of a nurse simulation training program on perception of kangaroo mother care (KMC) value and transfer skill competency. STUDY DESIGN:An 8-item Likert scale skill survey tool and a 24-item Likert developmental care survey tool were used in a prospective cohort study to analyze p...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1371359
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:Securing an arterial line to monitor continuous blood pressure (BP) is difficult in infants. We aimed to reveal the extent of discrepancies between oscillometric and direct BP. STUDY DESIGN:Infants who required continuous BP monitoring were prospectively enrolled. Direct and indirect BP were simultaneously r...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0034-1383851
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:To determine if patients with a history of low pregnancy-associated plasma protein A (PAPP-A) in an initial pregnancy are at higher risk for adverse obstetric outcomes in a subsequent pregnancy. STUDY DESIGN:This was a retrospective cohort study in patients who underwent first trimester screening for PAPP-A ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1673651
更新日期：2019-05-01 00:00:00
abstract：OBJECTIVE:To determine the risk of spontaneous preterm delivery (SPTD) associated with transvaginal cervical length (TVCL) in an unselected cohort. STUDY DESIGN:This is a retrospective study of serial TVCLs in unselected twin gestations. Receiver operator curves for SPTD were constructed from TVCLs at 18, 20, 22, and ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-0038-1676484
更新日期：2019-10-01 00:00:00
abstract：:A case of congenital left-sided diaphragmatic hernia complicated by formation of gastropleural fistula and Candida tropicalis empyema is presented. The possibility of pleural fistula should be considered in any undiagnosed case of pleural effusion, pneumothorax, empyema, hemothorax, or hydropneumothorax. ...
journal_title：American journal of perinatology
pub_type： 杂志文章
doi：10.1055/s-2007-999611
更新日期：1989-07-01 00:00:00
