Abstract:
:The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years. Between 1991 and 1994, 401 pregnant patients at risk for delivery prior to 34 weeks' gestation were invited to participate; 48 mothers declined entry. Before delivery, pharmacy randomized the pregnant women to receive phenobarbital and vitamin K or identically appearing placebo in a blinded fashion. Developmental follow-up at age 2 years was performed. Children from the treatment group scored significantly lower on the Bayley Mental Developmental Index (mean MDI +/- 1 SD) than children whose mothers were randomized to the placebo group [104 +/- 21 (n = 59) vs. 113 +/- 22 (n = 62), p = 0.023]. Of 36 independent variables, randomization group was one of five that individually contributed to the prediction of the Bayley MDI score (p < 0.05). It was concluded that perinatal phenobarbital therapy may impair developmental outcome.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Thorp JA,O'Connor M,Jones AM,Hoffman EL,Belden Bdoi
10.1055/s-2007-993836subject
Has Abstractpub_date
1999-01-01 00:00:00pages
51-60issue
2eissn
0735-1631issn
1098-8785journal_volume
16pub_type
临床试验,杂志文章,随机对照试验abstract::Objective To evaluate if an antibiotic automatic stop order (ASO) changed early antibiotic exposure (use in the first 7 days of life) or clinical outcomes in very low birth weight (VLBW) infants. Study Design We compared birth characteristics, early antibiotic exposure, morbidity, and mortality data in VLBW infants (w...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1584522
更新日期:2017-01-01 00:00:00
abstract::We sought to validate center-specific published medians and estimate the effects of sonologist and Doppler measurement techniques on middle cerebral artery (MCA) peak systolic velocity (PSV) values. We studied 154 gravidas with normal singletons who underwent MCA PSV measurement at 18 to 35 weeks' gestation by one of ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0030-1249365
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:This study aims to determine if transabdominal (TA) cervical length may be used to rule out a short cervix on transvaginal (TV) ultrasound. STUDY DESIGN:We conducted a prospective cohort study of women undergoing routine anatomic survey at 17 to 23 weeks gestation. TA and TV cervical length measurements were...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1566308
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess whether the location of the trocar insertion site for laser treatment of twin-twin transfusion syndrome was associated with preterm-premature rupture of membranes (PPROM) and preterm birth (PTB). STUDY DESIGN:In this study trocar location was documented in the operat...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1620268
更新日期:2018-07-01 00:00:00
abstract::We describe a case of transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia. Although hypoglycemia in birth asphyxiated infants is generally attributed to depletion of glycogen stores, we observed severe hyperinsulinism associated with the hypoglycemia. The hypoglycemia was refractory to high gl...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2001-15504
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To determine epidemiology and clinical characteristics of infants with methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA) in a level III neonatal intensive care unit (NICU). STUDY DESIGN:All NICU admissions (2001 to 2008) with any positive S. aureus culture were included as cases. Cas...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1304819
更新日期:2012-06-01 00:00:00
abstract::Premature closure of the foramen ovale is a rare cardiac anomaly. Severe right-sided heart failure accounts for the hepatomegaly, ascites, pleural and pericardial effusions, and generalized edema of these hydropic fetuses. Premature closure of the foramen ovale should be a part of the differential diagnosis when unexp...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994616
更新日期:1994-11-01 00:00:00
abstract::The aim of this study was to determine the risk of respiratory distress syndrome (RDS) and neonatal death (NND) in relation to birth weight in preterm neonates. A group of 255 singleton preterm neonates born at 22-36 weeks were examined. The mean birth weight for each gestational week was estimated from a fitted curve...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994327
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE: This article determines the tolerance of neonatal intensive care unit (NICU)-based administration of RV5 in premature infants. This article also aims to compare the rate of clinically significant adverse events after RV5 immunization to the standard 2-month shot series and to historical controls who were not...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1698455
更新日期:2019-11-18 00:00:00
abstract::It is well established that ultrasound measurement of femur length and biparietal diameter are comparably accurate estimators of gestational age when obtained in the first half of pregnancy. Both estimators, however, become less accurate later in pregnancy. The present study compares the relative accuracy of these est...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999837
更新日期:1986-04-01 00:00:00
abstract:OBJECTIVE:The Misgav-Ladach technique is recommended worldwide to perform cesarean sections but there is no consensus about the appropriate technique to use in patients with previous cesarean sections. This study evaluated the feasibility of the Misgav-Ladach technique in patients with previous cesarean sections. STUD...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-0032-1323580
更新日期:2013-03-01 00:00:00
abstract::Objective To compare maternal birth complications early versus late in the academic year and to evaluate the impact of resident work hour limitation on the "July effect." Study Design We conducted a retrospective, population-based cohort study of 628,414 singleton births in Washington State from 1987 to 2012 measuring...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0037-1598244
更新日期:2017-07-01 00:00:00
abstract::This study was conducted to examine the potential effects of expanded Medicaid coverage for low income women. Statewide birth data for 1983 to 1985 were examined to determine the relationship between prenatal care and admissions to neonatal intensive care units (NICUs) and the costs of this care. An NICU sample was co...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994790
更新日期:1992-07-01 00:00:00
abstract::It is widely believed that prenatal care is essential if women are to have healthy pregnancies and infants. Yet many low income women do not initiate care early in their pregnancies or make sufficient visits for prenatal care. Although financial difficulties are usually considered the main reason why prenatal care is ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994556
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Securing an arterial line to monitor continuous blood pressure (BP) is difficult in infants. We aimed to reveal the extent of discrepancies between oscillometric and direct BP. STUDY DESIGN:Infants who required continuous BP monitoring were prospectively enrolled. Direct and indirect BP were simultaneously r...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0034-1383851
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To determine the optimal click rate (CR) for neurodevelopmental assessment using auditory brainstem evoked response (ABR) in preterm infants. STUDY DESIGN:A prospective study was performed in 17 preterm infants at 34 weeks' postmenstrual age. Three separate ABRs were performed a few minutes apart on each sub...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1311982
更新日期:2012-09-01 00:00:00
abstract::Persistent fetal bradycardia is rarely encountered during pregnancy. When it is associated with a complete atrio-ventricular (A-V) block, it may prove dangerous to the fetus or newborn. The prenatal diagnosis is vital because it necessitates close follow-up during pregnancy to detect fetal compromise and proper prepar...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2007-994152
更新日期:1997-07-01 00:00:00
abstract::The incidence of triplet pregnancies has increased several times due to the widespread use of ovulation induction agents. Premature delivery is the main complication of triplet gestations. In twin conceptions it was shown definitely that elective cervical suture does not prolong these pregnancies. However, in higher o...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994691
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To reduce nonactionable oximeter alarms by 80% without increasing time infants were hypoxemic (oxygen saturation [SpO2] ≤ 80%) or hyperoxemic (SpO2 > 95% while on supplemental oxygen). STUDY DESIGN:In 2015, a multidisciplinary team at Connecticut Children's Medical Center initiated a quality improvement proj...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1653945
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:We assessed the utility of plasma B-type natriuretic peptide (BNP) in infants with persistent pulmonary hypertension of the newborn (PPHN) in the prediction of inhaled nitric oxide (iNO) requirement. METHODS:This prospective study involved neonates (gestational age ≥ 34 weeks) with PPHN and confirmatory echo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1548540
更新日期:2015-09-01 00:00:00
abstract::Extremely preterm infants often develop chronic lung disease (CLD) characterized by heterogeneous aeration; poorly supported, floppy airways; and air trapping. High-frequency jet ventilation (HFJV) with high end-expiratory pressure (optimal lung volume strategy [OLVS]) may improve airway patency, lead to better gas di...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2006-954821
更新日期:2006-11-01 00:00:00
abstract::The objective of this paper was to determine if routine postpartum hemoglobin (Hb) determination changes patient management. One thousand patients with a vaginal delivery at Hermann Hospital, Houston, TX, had antepartum Hb testing, and a postpartum Hb for: (1) an antepartum Hb <9.0 mg/dL, (2) an estimated blood loss (...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993881
更新日期:1999-01-01 00:00:00
abstract::Four hundred sixty-four fetuses underwent real time ultrasound examination within 72 hours before birth to evaluate other factors than the weight formula itself that might influence the accuracy of ultrasound weight estimation. The results indicated that fetal sex had no effect on weight estimation accuracy, but that ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999866
更新日期:1986-07-01 00:00:00
abstract::The purpose of this study was to compare risk factors between placental abruption and placenta previa among primiparous and multiparous singleton pregnancies. We analyzed data from a population-based retrospective cohort with singleton pregnancies in the United States for 1995 to 2000. Maternal risk factors for placen...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1103156
更新日期:2009-04-01 00:00:00
abstract::Periventricular leukomalacia (PVL) is a complication of prematurity that carries a high risk of long-term neurologic morbidity. We report the first case, to our knowledge, of unexpected PVL associated with in utero methamphetamine exposure in a 30-week gestation premature infant with a benign hospital course, who subs...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-970079
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:This study aimed to examine whether labor before cesarean affects the risk of placenta accreta spectrum (PAS) disorders in a subsequent pregnancy. STUDY DESIGN:This is a secondary analysis of the Cesarean Registry, a prospective cohort study of women undergoing cesarean between 1999 and 2002. Women with one ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1685449
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE: This study aimed to analyze whether hospital safety-net burden status is associated with increased risk for severe maternal morbidity (SMM) and postpartum readmissions. STUDY DESIGN: The 2010 to 2014 Nationwide Readmissions Database was utilized for this retrospective cohort study. Hospitals were categorize...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0040-1710544
更新日期:2020-05-05 00:00:00
abstract::We sought to evaluate the effectiveness of daily oral micronized progesterone (MP) in preventing recurrent spontaneous preterm birth (RSPB) and whether MP increases maternal serum progesterone. We performed a pilot, single-center, randomized, double-blind, placebo-controlled trial in women with a prior preterm birth a...
journal_title:American journal of perinatology
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0031-1274509
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to evaluate the impact of multiple pregnancies, maternal obesity, and preeclampsia on the effect of antenatal steroids on neonatal respiratory distress syndrome (RDS). STUDY DESIGN:The retrospective cohort study was performed in a level III maternity ward. Population was composed of ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1548537
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To identify single nucleotide polymorphisms (SNPs) associated with clinical chorioamnionitis among preterm infants. STUDY DESIGN:We reanalyzed a genome-wide association study (GWAS) from preterm newborns at less than 30 weeks' gestation. Cases and control definitions were determined using administrative reco...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1677503
更新日期:2019-12-01 00:00:00