Retinoblastoma.

Abstract:

:Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2 years of age and 95% before 5 years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, heritable form (25% of all cases), characterized by the presence of germline mutations of the RB1 gene; and (2) a unilateral or unifocal form (75% of all cases), 90% of which are nonhereditary. The treatment of retinoblastoma is multidisciplinary and is designed primarily to save life and preserve vision.

journal_name

Pediatr Clin North Am

authors

Rodriguez-Galindo C,Orbach DB,VanderVeen D

doi

10.1016/j.pcl.2014.09.014

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

201-23

issue

1

eissn

0031-3955

issn

1557-8240

pii

S0031-3955(14)00193-X

journal_volume

62

pub_type

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