Association of socioeconomic status with inflammatory markers: a two cohort comparison.

Abstract:

OBJECTIVE:To assess the association between socioeconomic status (SES) and inflammatory markers using two different European population samples. METHODS:We used data from the CoLaus (N=6412, Lausanne, Switzerland) and EPIPorto (N=1205, Porto, Portugal) studies. Education and occupational position were used as indicators of socioeconomic status (SES). High-sensitivity C-reactive protein (hs-CRP) was available for both cohorts. Interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) were available in CoLaus; leukocyte count and fibrinogen in EPIPorto. RESULTS:We showed that low SES was significantly associated with high inflammation in both studies. We also showed that behavioural factors contributed the most to SES differences in inflammation. In both studies the larger difference between the lowest and the highest SES was observed for hs-CRP. In the Swiss sample, a linear association between education and hs-CRP persisted after adjustment for all mediating factors and confounders considered (p for linear trend <0.001). CONCLUSION:Large social differences exist in inflammatory activity, in part independently from demographic and behavioural factors, chronic conditions and medication use. SES differences in inflammation are also similar in countries with different underlying socioeconomic conditions.

journal_name

Prev Med

journal_title

Preventive medicine

authors

Fraga S,Marques-Vidal P,Vollenweider P,Waeber G,Guessous I,Paccaud F,Barros H,Stringhini S

doi

10.1016/j.ypmed.2014.11.031

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

12-9

eissn

0091-7435

issn

1096-0260

pii

S0091-7435(14)00474-5

journal_volume

71

pub_type

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