Abstract:
:Letermovir (Prevymis™) is an orally or intravenously administered cytomegalovirus (CMV) DNA terminase complex inhibitor being developed by Merck & Co., Inc., under a global license from AiCuris Anti-infective Cures GmbH. Letermovir has been approved in Canada and the USA for the prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic haematopoietic stem cell transplant (HSCT). In addition, letermovir has received a positive opinion from the European Medicines Agency's Committee for Medicinal Products for Human Use, and is under review in several countries, including Japan. This article summarizes the milestones in the development of letermovir leading to its first global approval in Canada as well as the USA for the prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic HSCT.
journal_name
Drugsjournal_title
Drugsauthors
Kim ESdoi
10.1007/s40265-017-0860-8subject
Has Abstractpub_date
2018-01-01 00:00:00pages
147-152issue
1eissn
0012-6667issn
1179-1950pii
10.1007/s40265-017-0860-8journal_volume
78pub_type
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