Abstract：
OBJECTIVE:Appetite manipulation can be effective in weaning children off gastrostomy tube feeding dependence but can cause dehydration, hypoglycaemia, and ketone body production, which is anorexigenic. As the safety of this approach has not been described, our aim was to describe adverse events observed when weaning children from G-tube dependence using our appetite manipulation protocol. METHODS:This was a retrospective study of prospectively collected data of patients who completed our inpatient tube-weaning protocol. Daily safety parameters included twice-daily urine specific gravities and urine ketones and fasting capillary blood glucose. Graded clinical interventions to manage adverse events were collected. RESULTS:A total of 143 children with a mean age of 4.8 ± 2.4 years were seen in the inpatient feeding program of which 74 (51.7%) were male. The children were hospitalized 10.1 ± 2.5 days with the vast majority being discharged between days 11 and 14. Overall, 78.2% of patients experienced at least 1 adverse event: urine specific gravity >1.020 was seen in 60.5%, ketonuria in 48.9%, and hypoglycemia (≤60 mg/dL) in 13.4%. Only 2 children had blood glucose levels <40 mg/dL and these were corrected with oral supplementation. Graded clinical interventions to manage adverse events included oral rehydration in 89.9% of children and supplemental tube feeding in 25.2%. CONCLUSIONS:Adverse effects are common when appetite manipulation is used to wean children off G-tube dependence. Anticipating, monitoring, and having a clear intervention plan in a closely monitored setting are necessary to safely use this method.
journal_name
J Pediatr Gastroenterol Nutrjournal_title
Journal of pediatric gastroenterology and nutritionauthors
Pollow AS,Karls CA,Witzlib M,Noel RJ,Goday PS,Silverman AHdoi
10.1097/MPG.0000000000001849subject
Has Abstractpub_date
2018-05-01 00:00:00pages
e127-e130issue
5eissn
0277-2116issn
1536-4801journal_volume
66pub_type
杂志文章abstract：:Class II MHC antigen expression in the intestinal epithelium of 28 small bowel biopsies from 23 celiac patients were studied by means of indirect immunofluorescence and immunoperoxidase using monoclonal antibodies. Patients were divided on the basis of diet into two subgroups: 15 subjects on a gluten-containing diet (...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-198910000-00002
更新日期：1989-10-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to examine the expression of FOXP3, interleukin (IL)-10, transforming growth factor (TGF)-β1, IL-17A, and T helper 17 (TH17) cells/FOXP3+ regulatory T (Treg) cells balance in the gastric mucosa of children with Helicobacter pylori infection, in relation to the gastric histopat...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000000194
更新日期：2014-02-01 00:00:00
abstract：OBJECTIVES:Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective prop...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e318291fefe
更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:Diarrheal diseases remain a major human plague that still claim millions of lives every year. Probiotics, including Lactobacillus GG (LGG), are known to have a beneficial effect on diarrheal diseases, but their mechanism of action has not yet been completely established. Therefore, the main objective of this...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e3181924d1e
更新日期：2009-07-01 00:00:00
abstract：:Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed 16 cases of HSV esophagitis diagnosed from January 1982 to March 2016. Five patients w...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000001748
更新日期：2018-04-01 00:00:00
abstract：:Data about the use of ranitidine in the early postnatal period are lacking. In this study, 30 term newborn infants < 2 days old with bleeding erosions in their upper gastrointestinal tracts were treated with ranitidine by continuous i.v. infusion (0.2 mg/kg/h) for 48 h and thereafter by mouth (5 mg/kg b.i.d.) for 1 mo...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:A series of 31 infants, 28 with cow's milk protein sensitive enteropathy (CMPSE) and 3 controls, was studied for severity and extent of mucosal damage of the upper small bowel in relation to the development of clinical symptoms. Following challenge with the offending cow's milk, 18 infants (Group 1) developed severe m...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-198809000-00008
更新日期：1988-09-01 00:00:00
abstract：:Food-induced eosinophilic proctocolitis appears in the first 2 months of life with blood-tinged stools. Aside from occasional apparent pain on defecation and a few infants with moderate eczema, systemic features are absent. Indeed, aside from the diaper, the infant is generally described as well. Thus, in contrast to ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,评审
doi：10.1097/00005176-200001001-00009
更新日期：2000-01-01 00:00:00
abstract：:Severity scores are used to predict the outcome of acute pancreatitis (AP). Several scores are used in adult patients, but none has been thoroughly validated for specific use in paediatric patients. We retrospectively collected data from 48 children with AP (13 severe and 35 mild). The main causes were trauma (23%), i...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e318254c1c7
更新日期：2012-09-01 00:00:00
abstract：:The behavior and intraluminal esophageal pH of 48 infants (5-26 weeks old) were continuously recorded during the 120-min period following their ingestion of a standard volume of apple juice (pH approximately 4). To evaluate the effect of three basic behavior states on the frequency of infant gastroesophageal reflux, t...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199201000-00007
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVES:Children with coeliac disease (CD) have an increased number of chromosome aberrations in peripheral blood lymphocytes. Whether genetically determined or a secondary phenomenon in CD, chromosome abnormalities may be involved in the predisposition to cancer in CD patients. The aim of the study was to follow a ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-200402000-00014
更新日期：2004-02-01 00:00:00
abstract：:Constipation is a common pediatric problem. To assist health care professionals who care for children with constipation, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) previously published a clinical guideline based on an integration of medical evidence with expert opini...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,实务指引,评审
doi：10.1097/01.mpg.0000232574.41149.0a
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. METHODS:A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002797
更新日期：2020-09-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients. METHODS:Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002816
更新日期：2020-10-01 00:00:00
abstract：:Commissioned by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), we investigated how European physicians training in these fields are educated in nutrition. A survey on time spent in nutrition training, composition of multidisciplinary nutrition teams, and topics covered during...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002681
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:There is an inverse relationship between gestational age, birth weight and the time of first neonatal bowel movement. The authors hypothesized that delayed passage of meconium might result from a delayed maturation of the recto-anal inhibitory reflex (RAIR) in premature infants. OBJECTIVE:To evaluate whethe...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/01.mpg.0000150420.00161.b9
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVES:: Several serologic assays are commercially available to aid in the diagnosis of gluten-sensitive enteropathy (GSE). Our objective in this study was to assess the performance of a novel combined antigen-screening assay for GSE. PATIENTS AND METHODS:: Deidentified sera from 111 pediatric patients suspected o...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e3181c992be
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess health-related quality of life (HRQOL) using the Coeliac Disease Dutch Questionnaire (CDDUX) in Spanish children with coeliac disease. METHODS:The CDDUX was cross-culturally adapted according to international consensus guidelines. HRQOL was assessed in coeliac members of t...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000000963
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Starch is an important source of energy for children with cystic fibrosis, but little is known about their capacity to digest it. METHODS:A 13C breath test was used to measure starch digestion and oxidation in 16 children with cystic fibrosis (median [range] age, 7.9 [4-15] years; 7 girls, 9 boys) and 5 nor...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199909000-00016
更新日期：1999-09-01 00:00:00
abstract：:We studied the effects of breast milk feeding versus formula feeding during the first 8 weeks of life on the development of local gastrointestinal humoral immune response by measuring fecal secretory immunoglobulin A (SIgA). Forty-four infants were studied and classified into two groups: breast milk (n = 21) and stand...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:A mattress and plastic bed for collection of urine and feces in premature infants housed in isolettes is described. The dimensions of the bed are 65.5 x 34.4 x 13.5 cm. A drainage hole is located 18 cm from the foot of the bed and midway (16.5 cm) from either side. The angle of the depression in the bed for the draina...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199005000-00011
更新日期：1990-05-01 00:00:00
abstract：OBJECTIVES:Duodenal tube test (DTT) is used as a preoperative screening to rule out biliary atresia (BA). In previous reports, DTT was assessed by the color of the duodenal fluid, but there were no quantitative criteria. The aim of this study was to examine the efficacy of DTT based on the total bile acid (TBA) concent...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002037
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to quantify the differences in viscosity of over a range of commercial food-based formulas and home-prepared blenderized feeds used for enteral feeding in the clinical management of gastroesophageal reflux and gastroesophageal reflux-related aspiration in children with oropharyngeal d...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002657
更新日期：2020-06-01 00:00:00
abstract：OBJECTIVES:The aim of this systematic review and meta-analysis was to assess immune response to vaccination in children and young people with inflammatory bowel disease (IBD). In patients with IBDs, both the disease itself and its treatment can affect the vaccine response. METHODS:Medical databases were searched for r...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002810
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Although a dextran sodium sulfate (DSS)-induced colitis is commonly used as an ulcerative colitis (UC) model in adult rodents, there are no studies using this model in young animals. We examined differences in the severity of DSS-induced colitis as a function of the concentration of DSS administered and soug...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-200310000-00015
更新日期：2003-10-01 00:00:00
abstract：:Mucins are complex glycoproteins that cover the intestinal mucosal surface and are thought to provide protection against enteropathogenic infections by preventing bacterial adherence and subsequent colonization, invasion and toxin delivery. The aims of this study was to evaluate the capacity of intestinal mucin to inh...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199510000-00004
更新日期：1995-10-01 00:00:00
abstract：:IgA anti-gliadin antibodies (AGA), interleukin-2 (IL-2), and soluble interleukin-2 receptor (sIL-2R) were analyzed in serum from 28 children with symptoms of celiac disease and villous atrophy in at least their first small bowel biopsy. We also assayed IL-2 and sIL-2R in 45 healthy children and IgA anti-gliadin antibo...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199101000-00012
更新日期：1991-01-01 00:00:00
abstract：:We describe a 5-year-old white girl who presented at 18 months of age with an ileal perforation and radiographic evidence of segmental intestinal narrowing. Her initial diagnosis was Crohn's disease; however, on subsequent microscopic review, her lesion consisted of mixed histiocytic and eosinophilic infiltration char...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：BACKGROUND:Patients with autoimmune diseases, such as type 1 diabetes mellitus, atopic dermatitis, autoimmune thyroid diseases, and multiple sclerosis have a different seasonality of month of birth (MOB) from the general population. This study was undertaken to determine the seasonality of MOB in children with celiac d...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e3181709530
更新日期：2009-02-01 00:00:00
abstract：OBJECTIVES:Eosinophilic esophagitis (EoE) is a clinicopathologic disorder characterized by infiltration of eosinophils into the esophagus. Primary treatment approaches include topical corticosteroids and/or food elimination. The aim of the present study was to compare the effectiveness of combination therapy (topical c...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000001584
更新日期：2017-06-01 00:00:00
