当前位置： SCI文献检索 > JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION期刊下所有文献 > Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children.

Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children.

Abstract：

OBJECTIVES:Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD. METHODS:We included consecutive children with biopsy-proven NAFLD and obtained demographic, clinical, and histopathological data. We performed logistic regression analysis to assess the clinical factors associated with the histological features of NASH or fibrosis. RESULTS:From a total of 302 biopsies, 67% (203) had evidence of NASH, whereas 64.2% had some degree of fibrosis (stage 1 in 51%, stage 2 in 6.3%, and stage 3 in 6.6%). Mean total bilirubin was significantly lower in the NASH group compared with the non-NASH group (0.65 ± 0.24 vs 0.73 ± 0.22 mg/dL, P = 0.007). Higher total bilirubin levels were negatively correlated with the presence of steatosis and the NAFLD activity score (P < 0.05), whereas a trend in that direction was observed for presence of fibrosis and inflammation (P = 0.051). On multivariable analysis, higher bilirubin levels were significantly associated with a decreased likelihood of a histological diagnosis of NASH on biopsy (odds ratio 0.29, 95% CI 0.10-0.85, P = 0.024). CONCLUSIONS:In children with NAFLD, there is an inverse relation between serum bilirubin levels and the presence of NASH on biopsy. This may be secondary to the antioxidant effect of bilirubin.

journal_name

J Pediatr Gastroenterol Nutr

journal_title

Journal of pediatric gastroenterology and nutrition

authors

Puri K,Nobili V,Melville K,Corte CD,Sartorelli MR,Lopez R,Feldstein AE,Alkhouri N

doi

10.1097/MPG.0b013e318291fefe

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

114-8

issue

1

eissn

0277-2116

issn

1536-4801

journal_volume

57

pub_type

杂志文章

相关文献

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION文献大全
  • Cow's Milk Allergy Prescribing Is Influenced by Regional and National Guidance.

    abstract：OBJECTIVES:Cow's milk allergy (CMA) is the most common food allergy in children with many clinical manifestations, leading to misdiagnoses such as gastro-oesophageal reflux, infantile colic, and lactose intolerance with inappropriate prescribing. We aimed to determine the impact of infant feeding guidelines on CMA pres...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000001052

    authors： Wauters L,Brown T,Venter C,Dziubak R,Meyer R,Brogan B,Walsh J,Fox AT,Shah N

    更新日期：2016-05-01 00:00:00

  • Donor Human Milk and Fortifier Use in United States Level 2, 3, and 4 Neonatal Care Hospitals.

    abstract：OBJECTIVE:In 2011, the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of the present study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facili...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000001790

    authors： Perrin MT

    更新日期：2018-04-01 00:00:00

  • Diet and Exercise in Pediatric Liver Transplant Recipients: Behaviors and Association With Metabolic Syndrome.

    abstract：OBJECTIVE:The aim of the study is to analyze the impact of physical activity and eating behaviors on precursors of cardiovascular disease-including overweight/obesity, hypertension, low high-density lipoprotein, and impaired glucose tolerance-in pediatric liver transplant (LT) recipients and matched controls. METHOD:C...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000002150

    authors： Chambers JH,Zerofsky M,Lustig RH,Rosenthal P,Perito ER

    更新日期：2019-01-01 00:00:00

  • Breath methane production in children with constipation and encopresis.

    abstract：:Breath methane excretion is uncommon in children compared with adults. Certain intracolonic conditions, however, have been associated with enhanced methane generation. We hypothesized that encopretic and constipated children, who have abnormal colonic transit times, more likely would excrete methane than healthy child...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-199005000-00010

    authors： Fiedorek SC,Pumphrey CL,Casteel HB

    更新日期：1990-05-01 00:00:00

  • Tolerability, safety, and efficacy of PEG 3350 as a 1-day bowel preparation in children.

    abstract：OBJECTIVE:The aim of the study was to evaluate the tolerability, safety, and efficacy of polyethylene glycol (PEG) 3350 without electrolytes as a 1-day bowel preparation for colonoscopy in children. METHODS:A prospective study of 45 children undergoing colonoscopy prescribed PEG 3350 without electrolytes mixed with a ...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0b013e3182758c69

    authors： Walia R,Steffen R,Feinberg L,Worley S,Mahajan L

    更新日期：2013-02-01 00:00:00

  • Efficacy of bismuth-based triple therapy in children with abdominal pain and Helicobacter pylori gastritis.

    abstract：BACKGROUND:To evaluate the effect of a therapeutic regimen of 7 days versus 14 days on the clinical manifestations of Helicobacter pylori gastritis in children. METHODS:Ninety children (age 2-19 years) who had abdominal pain and/or recurrent vomiting were determined to have H. pylori gastritis by endoscopy, histology,...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1097/00005176-200002000-00018

    authors： Shamaly H,Berkowitz D,Rosenthal E,Naveh Y

    更新日期：2000-02-01 00:00:00

  • Plasma amino acids after a feed of human milk or formula at three months of age.

    abstract：:Prefeeding plasma amino acid concentrations were higher and glycine-to-valine ratios lower in formula-fed infants as compared to breast-fed infants at 3 months of age. After a human milk meal (true protein, 0.8 g/100 ml) or formula meal (1.5 g/100 ml), all essential and several nonessential amino acids peaked at 30-60...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：

    authors： Tikanoja T,Simell O

    更新日期：1983-05-01 00:00:00

  • Quality of life in children with Crohn's disease.

    abstract：:In a 10-week randomised cross-sectional study we used an 88-item questionnaire to assess the quality of life in 16 children (ages 8-17 years) with Crohn's disease and their families. The questionnaire covered six domains of health-related quality of life, including disease and its treatment, social, emotional, family,...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-199612000-00003

    authors： Rabbett H,Elbadri A,Thwaites R,Northover H,Dady I,Firth D,Hillier VF,Miller V,Thomas AG

    更新日期：1996-12-01 00:00:00

  • Eosinophilic oesophagitis in infants and children in the region of southern Denmark: a prospective study of prevalence and clinical presentation.

    abstract：OBJECTIVE:Eosinophilic oesophagitis (EE) is a clinical entity characterised by a set of symptoms and eosinophilic infiltration of the oesophageal epithelium. Recent reports indicate that EE is increasingly diagnosed in paediatric patients. We aimed to evaluate the epidemiology of paediatric EE in a European population....

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0b013e3181d1b107

    authors： Dalby K,Nielsen RG,Kruse-Andersen S,Fenger C,Bindslev-Jensen C,Ljungberg S,Larsen K,Walsted AM,Husby S

    更新日期：2010-09-01 00:00:00

  • Ascites complicating ventriculoperitoneal shunts.

    abstract：:Ventriculoperitoneal shunts are currently a standard therapy for obstructive hydrocephalus. These shunts are associated with a variety of abdominal complications, one of which is the development of ascites. We report an 11-year-old girl with a ventriculoperitoneal shunt in whom a low-grade peritoneal infection present...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-198809000-00028

    authors： Goodman GM,Gourley GR

    更新日期：1988-09-01 00:00:00

  • Changes in Proteases, Antiproteases, and Bioactive Proteins From Mother's Breast Milk to the Premature Infant Stomach.

    abstract：OBJECTIVE:Our previous studies suggested that human milk proteases begin to hydrolyze proteins in the mammary gland and continue within the term infant' stomach. No research has measured milk protease and pepsin activity in the gastric aspirates of preterm infants after human milk feeding. This study investigated how t...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000001719

    authors： Demers-Mathieu V,Nielsen SD,Underwood MA,Borghese R,Dallas DC

    更新日期：2018-02-01 00:00:00

  • Severity of Villous Atrophy at Diagnosis in Childhood Does Not Predict Long-term Outcomes in Celiac Disease.

    abstract：OBJECTIVES:Current pediatric guidelines allow noninvasive diagnosis of celiac disease in selected children. We investigated in a large cohort study whether the severity of villous atrophy at diagnosis is associated with clinical characteristics or long-term health outcomes, thus having a prognostic significance. METHO...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000002675

    authors： Kröger S,Kurppa K,Repo M,Huhtala H,Kaukinen K,Lindfors K,Arvola T,Kivelä L

    更新日期：2020-07-01 00:00:00

  • Serum transaminases in children with Wilson's disease.

    abstract：OBJECTIVES:The response of serum transaminase levels to penicillamine and zinc treatment in Wilson's disease is poorly understood. The aim of this multicenter retrospective study was to evaluate transaminase levels after penicillamine and zinc treatment in children with Wilson's disease. PATIENTS AND METHODS:One hundr...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-200410000-00006

    authors： Iorio R,D'Ambrosi M,Marcellini M,Barbera C,Maggiore G,Zancan L,Giacchino R,Vajro P,Marazzi MG,Francavilla R,Michielutti F,Resti M,Frediani T,Pastore M,Mazzarella G,Fusco G,Cirillo F,Vegnente A,Hepatology Committee of

    更新日期：2004-10-01 00:00:00

  • Electrogastrography, Near-infrared Spectroscopy, and Acoustics to Measure Gastrointestinal Development in Preterm Babies.

    abstract：OBJECTIVES:The aim of the study was to obtain objective measures indicative of gastrointestinal maturity using 3 noninvasive technologies. METHODS:Electrogastrography (EGG), abdominal near-infrared spectroscopy (NIRS), and bowel sound/acoustics (AC) monitoring were used simultaneously to obtain physiologic measures of...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 临床试验,杂志文章

    doi：10.1097/MPG.0000000000001867

    authors： Ortigoza EB,Cagle J,Chien JH,Oh S,Brown LS,Neu J

    更新日期：2018-06-01 00:00:00

  • Lactose in blood in nonpregnant, pregnant, and lactating women.

    abstract：:Lactose synthesized in the mammary gland can pass into the bloodstream by either a paracellular or transcellular pathway. In nonpregnant, nonlactating women, the concentration of lactose in the blood plasma was 1.5 +/- 0.1 microM (mean +/- SEM) in 9 women and undetectable in another 11 women. During pregnancy, this co...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-199110000-00003

    authors： Arthur PG,Kent JC,Potter JM,Hartmann PE

    更新日期：1991-10-01 00:00:00

  • Incidence, clinical presentation and location at diagnosis of pediatric inflammatory bowel disease: a prospective population-based study in northern France (1988-1999).

    abstract：OBJECTIVE:To assess the incidence and location at diagnosis of inflammatory bowel disease in children and adolescents in northern France between 1988 and 1999. METHODS:A 12-year prospective population-based study was conducted by gastroenterologists and pediatric gastroenterologists of northern France (1,312,141 child...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/01.mpg.0000162479.74277.86

    authors： Auvin S,Molinié F,Gower-Rousseau C,Brazier F,Merle V,Grandbastien B,Marti R,Lerebours E,Dupas JL,Colombel JF,Salomez JL,Cortot A,Turck D

    更新日期：2005-07-01 00:00:00

  • Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.

    abstract：OBJECTIVES:The intestinal brush border enzymes alkaline sphingomyelinase (alk-SMase) and neutral ceramidase (CDase) digest milk sphingomyelin in suckling neonates. In addition, alk-SMase, CDase, and acid sphingomyelinase (acid-SMase) have been implicated in sphingolipid signaling, which exhibits abnormalities in cystic...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0b013e3181826daf

    authors： Ohlsson L,Hjelte L,Hühn M,Scholte BJ,Wilke M,Flodström-Tullberg M,Nilsson A

    更新日期：2008-11-01 00:00:00

  • Early Obesity: Risk Factor for Fatty Liver Disease.

    abstract：:Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for live...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000002523

    authors： Cuzmar V,Alberti G,Uauy R,Pereira A,García C,De Barbieri F,Corvalán C,Santos JL,Mericq V,Villarroel L,Gana JC

    更新日期：2020-01-01 00:00:00

  • Crying does not exacerbate gastroesophageal reflux in infants.

    abstract：:The behavior and intraluminal esophageal pH of 48 infants (5-26 weeks old) were continuously recorded during the 120-min period following their ingestion of a standard volume of apple juice (pH approximately 4). To evaluate the effect of three basic behavior states on the frequency of infant gastroesophageal reflux, t...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-199201000-00007

    authors： Orenstein SR

    更新日期：1992-01-01 00:00:00

  • Hepatitis B virus in the colostra of HBeAg-positive carrier mothers.

    abstract：:To investigate the amount of hepatitis B virus (HBV) in colostra of hepatitis B e antigen (HBeAg)-positive carrier mothers and the relationship of HBV amount between colostrum and maternal blood, 50 HBeAg-positive carrier mothers were recruited and studied for hepatitis B surface antigen (HBsAg) titer, HBeAg titer, an...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-199308000-00014

    authors： Lin HH,Hsu HY,Chang MH,Chen PJ,Chen DS

    更新日期：1993-08-01 00:00:00

  • Systematic Evaluation of Diagnostic Delay in Pediatric Inflammatory Bowel Disease.

    abstract：:We evaluated the diagnostic delay (time from first symptoms to diagnosis) in 100 pediatric patients with Crohn disease (CD) and 75 patients with ulcerative colitis (UC). Median (interquartile range) diagnostic delay in patients with CD was 4 (2-8) (range 0-82) months compared with 2 (1-7) (range 0-52) months in patien...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000001238

    authors： Schoepfer AM,Vavricka S,Safroneeva E,Fournier N,Manser C,Frei P,Deltenre P,Rogler G,Straumann A,Ezri J,Nydegger A,Braegger C

    更新日期：2017-02-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of lansoprazole in children 13 to 24 months old with gastroesophageal reflux disease.

    abstract：OBJECTIVES:To evaluate the pharmacokinetics and pharmacodynamics of lansoprazole in children between 13 and 24 months of age with gastroesophageal reflux disease (GERD). METHODS:From the population of 66 children with symptomatic GERD, erosive esophagitis (> or = grade 2) or esophageal pH < 4 for > 4.2% of the 24-h pe...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章,多中心研究

    doi：10.1097/01.mpg.0000242556.57434.2e

    authors： Heyman MB,Zhang W,Huang B,Chiu YL,Amer F,Winter HS

    更新日期：2007-01-01 00:00:00

  • Severity and extent of upper small bowel mucosal damage in cow's milk protein-sensitive enteropathy.

    abstract：:A series of 31 infants, 28 with cow's milk protein sensitive enteropathy (CMPSE) and 3 controls, was studied for severity and extent of mucosal damage of the upper small bowel in relation to the development of clinical symptoms. Following challenge with the offending cow's milk, 18 infants (Group 1) developed severe m...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-198809000-00008

    authors： Iyngkaran N,Yadav M,Boey CG,Lam KL

    更新日期：1988-09-01 00:00:00

  • Clinical safety of Lactobacillus casei shirota as a probiotic in critically ill children.

    abstract：OBJECTIVE:Diarrhea is frequently observed among critically ill children (CIC) admitted for intensive care. There is increasing evidence that probiotics decrease the incidence of acute infectious and nosocomial and antibiotic induced diarrhea amongst children hospitalized in nonintensive care settings. Despite theoretic...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1097/01.mpg.0000189335.62397.cf

    authors： Srinivasan R,Meyer R,Padmanabhan R,Britto J

    更新日期：2006-02-01 00:00:00

  • Nutritional copper deficiency in severely handicapped patients on a low copper enteral diet for a prolonged period: estimation of the required dose of dietary copper.

    abstract：:Six cases of nutritional copper deficiency were identified in a nursery institute for severely handicapped patients. All had been on prolonged enteral feeding of a copper-deficient diet and all had abnormalities related to the copper deficiency. Two of them had leukopenia, with or without macrocytic and normochromic a...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-198807000-00018

    authors： Higuchi S,Higashi A,Nakamura T,Matsuda I

    更新日期：1988-07-01 00:00:00

  • Clinical response to 2 dosing regimens of lansoprazole in infants with gastroesophageal reflux.

    abstract：:Proton pump inhibitors such as lansoprazole are used in the treatment of gastroesophageal reflux disease (GERD), but dosing guidelines for infants have not been determined. The objective of this study was to assess the clinical efficacy of 2 dosing regimens of lansoprazole in infants with GERD using the revised infant...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1097/MPG.0b013e31815667d7

    authors： Khoshoo V,Dhume P

    更新日期：2008-03-01 00:00:00

  • Nutritional zinc balance in extremely low-birth-weight infants.

    abstract：BACKGROUND:Zinc is important for metabolism, cell growth, immunity, and defense against oxygen radicals. Extremely low-birth-weight (< 1000 g) infants have higher nutritional needs, but information on zinc is scarce. The authors performed nutritional balances in 10 infants with birth weights of 500 to 999 g and who wer...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/00005176-200104000-00009

    authors： Loui A,Raab A,Obladen M,Brätter P

    更新日期：2001-04-01 00:00:00

  • Role of Treg and TH17 cells of the gastric mucosa in children with Helicobacter pylori gastritis.

    abstract：OBJECTIVE:The aim of the present study was to examine the expression of FOXP3, interleukin (IL)-10, transforming growth factor (TGF)-β1, IL-17A, and T helper 17 (TH17) cells/FOXP3+ regulatory T (Treg) cells balance in the gastric mucosa of children with Helicobacter pylori infection, in relation to the gastric histopat...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000000194

    authors： Gil JH,Seo JW,Cho MS,Ahn JH,Sung HY

    更新日期：2014-02-01 00:00:00

  • Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study.

    abstract：BACKGROUND AND OBJECTIVES:Breast milk contains several bioactive factors including human milk oligosaccharides (HMOs) and microbes that shape the infant gut microbiota. HMO profile is determined by secretor status; however, their influence on milk microbiota is still uncovered. This study is aimed to determine the impa...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000002216

    authors： Cabrera-Rubio R,Kunz C,Rudloff S,García-Mantrana I,Crehuá-Gaudiza E,Martínez-Costa C,Collado MC

    更新日期：2019-02-01 00:00:00

  • Barriers and Facilitators to a Good Bowel Preparation for Colonoscopy in Children: A Qualitative Study.

    abstract：BACKGROUND:A well-visualized colon during colonoscopy has a direct impact on interpretation of findings and need for repeat procedure. Studies have been conducted in the adult population to assess factors contributing to improved bowel preparation. The primary aim of this study was to determine barriers and facilitator...

    journal_title：Journal of pediatric gastroenterology and nutrition

    pub_type： 杂志文章

    doi：10.1097/MPG.0000000000001935

    authors： Hart L,Nael H,Longmire NM,Zachos M

    更新日期：2018-08-01 00:00:00