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Controlled versus hyperemic flow during reperfusion of jeopardized ischemic myocardium.

Abstract：

:Controlled versus uncontrolled reperfusion of ischemic myocardium after experimental coronary artery occlusion was studied to determine the effect on regional ventricular wall motion and associated biochemical alterations. Fourteen pigs underwent coronary artery occlusion for 1 hour followed by 2 hours of reperfusion. In seven animals uncontrolled reperfusion was achieved by complete release of the arterial occlusion resulting in hyperemic flow. In seven other animals coronary flow during reperfusion was controlled at baseline levels eliminating hyperemic flow. Our results show that controlled reperfusion lessens end-diastolic wall thickness, reduces myocardial calcium deposition, increases the rate of mitochondrial oxidative phosphorylation, and preserves cellular high-energy phosphate stores in the ischemic-reperfused myocardium when compared to the uncontrolled reperfusion state. These data suggest that the magnitude of flow at an early stage of reperfusion is one of the important determinants in the outcome of ischemic myocardium.

journal_name

Am Heart J

journal_title

American heart journal

authors

Peng CF,Murphy ML,Colwell K,Straub KD

doi

10.1016/0002-8703(89)90723-0

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

515-22

issue

3

eissn

0002-8703

issn

1097-6744

pii

0002-8703(89)90723-0

journal_volume

117

pub_type

杂志文章

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