Abstract：
PURPOSE:Exercise is associated with altered gut microbial composition, but studies have not investigated whether the gut microbiota and associated metabolites are modulated by exercise training in humans. We explored the impact of 6 wk of endurance exercise on the composition, functional capacity, and metabolic output of the gut microbiota in lean and obese adults with multiple-day dietary controls before outcome variable collection. METHODS:Thirty-two lean (n = 18 [9 female]) and obese (n = 14 [11 female]), previously sedentary subjects participated in 6 wk of supervised, endurance-based exercise training (3 d·wk) that progressed from 30 to 60 min·d and from moderate (60% of HR reserve) to vigorous intensity (75% HR reserve). Subsequently, participants returned to a sedentary lifestyle activity for a 6-wk washout period. Fecal samples were collected before and after 6 wk of exercise, as well as after the sedentary washout period, with 3-d dietary controls in place before each collection. RESULTS:β-diversity analysis revealed that exercise-induced alterations of the gut microbiota were dependent on obesity status. Exercise increased fecal concentrations of short-chain fatty acids in lean, but not obese, participants. Exercise-induced shifts in metabolic output of the microbiota paralleled changes in bacterial genes and taxa capable of short-chain fatty acid production. Lastly, exercise-induced changes in the microbiota were largely reversed once exercise training ceased. CONCLUSION:These findings suggest that exercise training induces compositional and functional changes in the human gut microbiota that are dependent on obesity status, independent of diet and contingent on the sustainment of exercise.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Allen JM,Mailing LJ,Niemiro GM,Moore R,Cook MD,White BA,Holscher HD,Woods JAdoi
10.1249/MSS.0000000000001495subject
Has Abstractpub_date
2018-04-01 00:00:00pages
747-757issue
4eissn
0195-9131issn
1530-0315journal_volume
50pub_type
杂志文章abstract：PURPOSE:To investigate the effects of training intensity and duration, through a range representative of training in endurance athletes, on acute recovery of autonomic nervous system (ANS) balance after exercise. METHODS:Nine highly trained (HT) male runners (VO2max 72 +/- 5 mL.kg.min(-1), 14 +/- 3 training hours per ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/mss.0b013e318060f17d
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abstract：INTRODUCTION:The SenseWear Pro Armband (SWA) has been shown to be a valid and practical tool to assess energy expenditure (EE) in adults. However, recent studies have reported significant errors in EE estimates when the algorithms are applied to children. The purpose of this study was to assess the validity of recently...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181a071cf
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journal_title：Medicine and science in sports and exercise
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doi：10.1249/MSS.0b013e318270b381
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/01.mss.0000128245.39808.36
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doi：10.1249/MSS.0000000000001692
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：10.1249/MSS.0b013e3181d9eea0
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journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Medicine and science in sports and exercise
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doi：
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
doi：10.1249/MSS.0000000000000891
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/00005768-199507000-00012
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e318182092b
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
doi：
更新日期：1992-05-01 00:00:00
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doi：10.1249/MSS.0000000000000271
更新日期：2014-08-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Medicine and science in sports and exercise
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doi：10.1097/00005768-199804000-00006
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e31827bd397
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journal_title：Medicine and science in sports and exercise
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更新日期：2016-05-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
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更新日期：2006-07-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1993-09-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/mss.0b013e3180686dc7
更新日期：2007-08-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,评审
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更新日期：2005-09-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
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更新日期：2008-05-01 00:00:00
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journal_title：Medicine and science in sports and exercise
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章,随机对照试验
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journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To determine the optimal crank length and crank-axle height for maximum power production during standing arm cranking ("grinding"). METHODS:Nine elite professional America's Cup grinders (age = 36 +/- 2 yr, body mass = 104 +/- 1 kg, body fat = 13% +/- 2%) performed eight maximal 6-s sprints on an adjustable ...
journal_title：Medicine and science in sports and exercise
pub_type： 杂志文章
doi：10.1249/MSS.0b013e3181b46f3a
更新日期：2010-02-01 00:00:00
