Abstract:
PURPOSE:Maternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic dysfunction. Because preventive approaches in this context are missing to date, we aimed to identify molecular mechanisms in the offspring that are affected by maternal exercise during pregnancy. METHODS:Diet-induced obese mouse dams were divided into a sedentary obese (high-fat diet [HFD]) group and an obese intervention (HFD-running intervention [RUN]) group, which performed voluntary wheel running throughout gestation. Male offspring were compared with the offspring of a sedentary lean control group at postnatal day 21. RESULTS:HFD and HFD-RUN offspring showed increased body weight and white adipose tissue mass. Glucose tolerance testing showed mild impairment only in HFD offspring. Serum interleukin-6 (IL-6) levels, hypothalamic and white adipose tissue IL-6 gene expressions, and phosphorylation of signal transducer and activator of transcription 3 in HFD offspring were significantly increased, whereas HFD-RUN was protected against these changes. The altered hypothalamic global gene expression in HFD offspring showed partial normalization in HFD-RUN offspring, especially with respect to IL-6 action. CONCLUSION:Maternal exercise in obese pregnancies effectively reduces IL-6 trans-signaling and might be the underlying mechanism for the amelioration of glucose metabolism at postnatal day 21 independent of body composition.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Bae-Gartz I,Janoschek R,Kloppe CS,Vohlen C,Roels F,Oberthür A,Alejandre Alcazar MA,Lippach G,Muether PS,Dinger K,Ferrari N,Graf C,Dötsch J,Hucklenbruch-Rother Edoi
10.1249/MSS.0000000000000835subject
Has Abstractpub_date
2016-05-01 00:00:00pages
829-38issue
5eissn
0195-9131issn
1530-0315journal_volume
48pub_type
杂志文章abstract:PURPOSE:The purpose of this investigation was to examine the effects of differing amounts of beta-hydroxy-beta-methylbutyrate (HMB), 0, 36, and 76 mg x kg(-1) x d(-1), on hematology, hepatic and renal function during 8 wk of resistance training. METHODS:Thirty-seven, untrained collegiate males and were randomly assign...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200012000-00023
更新日期:2000-12-01 00:00:00
abstract::The availability of choline, the precurser of the neurotransmitter, acetylcholine, in the diet is sufficient to provide the body's requirements under normal conditions. However, preliminary evidence indicates that depletion of choline may limit performance, while oral supplementation may delay fatigue during prolonged...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1995-05-01 00:00:00
abstract::The ventilatory threshold (VT) has been suggested as a method for determining exercise training intensity in cardiac transplant patients (CTPs). Since the VT has not been validated against the more accepted marker of the anaerobic threshold, the lactate threshold (LT), in CTPs, the purpose of this investigation was to...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:PURPOSE:The range of variability between individuals of the same chronological age (CA) in somatic and biological maturity is large and especially accentuated around the adolescent growth spurt. Maturity assessment is an important consideration when dealing with adolescents, from both a research perspective and youth s...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200204000-00020
更新日期:2002-04-01 00:00:00
abstract::In the present studies, the Leuven Tennis Performance Test (LTPT), a newly developed test procedure to measure stroke performance in match-like conditions in elite tennis players, was evaluated as to its value for research purposes. The LTPT is enacted on a regular tennis court. It consists of first and second service...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199808000-00016
更新日期:1998-08-01 00:00:00
abstract:PURPOSE:To assess reliability and validity of the 7-d physical activity recall (PAR) in 60- to 80-yr-old men from urban and rural homes in the southeastern United States. METHODS:Two hundred twenty 60- to 80-yr-old men (29% minority ethnicity) from Veterans Affairs primary care clinics completed two PAR interviews at ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000139893.65189.f2
更新日期:2004-09-01 00:00:00
abstract::It has been widely claimed that exercise is beneficial to dysmenorrhea, yet solid evidence is lacking. Studies investigating this relationship have been reviewed for this paper. Most showed decreased prevalence and/or improved symptomatology with exercise. However, controlled longitudinal studies involving women with ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199806000-00020
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:We investigated technical and physiological responses along with their relationships during an incremental field test to exhaustion specific to tennis (TEST) in elite players. METHODS:Twenty male elite tennis players completed TEST, which consisted of hitting alternatively forehand and backhand strokes at incr...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001303
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:This study aimed to establish whether time spent in sport-related physical activities and sedentary behaviors (e.g., TV viewing, videogame usage, and homework) was prospectively associated with change in blood pressure (BP) for 5 yr. METHODS:Eight hundred and twenty-one students age 6 yr at baseline (397 girls...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000166
更新日期:2014-04-01 00:00:00
abstract::This article focuses on sports related spinal cord and nerve injuries, ranging from mild "stinger" syndrome to complete quadriplegia. Particular emphasis is placed on recommendations for return to competition after such injuries. Cervical spinal cord symptoms after a spine injury from contact sports require a more pre...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199707001-00005
更新日期:1997-07-01 00:00:00
abstract::The present study examined the validity of selected bioelectrical impedance (BIA) equations for estimating percent fat (% fat) in males and compared their validity with that of a commonly used skinfold equation (Sum3). One-hundred twenty-two Caucasian males (X +/- SD = 12.5 +/- 5.8% fat, as determined by underwater we...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199604000-00019
更新日期:1996-04-01 00:00:00
abstract:PURPOSE:Physical activity (PA) promotion among youth is a public health priority, and there is a need for robust surveillance systems to help support such initiatives. Existing youth PA self-report instruments that are used for surveillance lack information regarding the types and contexts of activity. Further, these i...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001562
更新日期:2018-06-01 00:00:00
abstract::The extent of the growth changes in maximal work output during 10 s (MWO10), 30 s (MWO30), and 90 s (MWO90) of maximal repetitive knee flexions and extensions assessed on a modified Hydra-Gym machine was investigated in 84 boys and 83 girls, 9-19 yr of age. Body weight, fat mass and fat free mass by underwater weighin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::The advantages of performing simultaneous inferences on the means of several response variables using multivariate analysis of variance are discussed. They include control over the problem of declaring false significant differences and the ability to investigate the effects of treatment on a given response variable af...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:The main purpose of the present study was to measure the total oxygen consumed, accumulation of blood metabolites, and performance during alternating intensity exercise before and after a period of creatine (Cr) loading in well-trained humans. METHODS:Fourteen males were randomly assigned to two groups of seve...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200002000-00018
更新日期:2000-02-01 00:00:00
abstract::Ski charging was measured using giant-slalom style skis as gliding capacitors. The voltage measured across the plates was proportional to the charge on the base. While resting on dry snow or suspended in the air, the voltage was slowly reduced by the data logger itself. On wet snow the decay was much faster. While sta...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:This study examined the effect of endurance exercise on dendritic arborization in the dentate gyrus subregion in rodents exposed to a predator scent stress (PSS). METHODS:Sprague-Dawley rats were randomly assigned to one of four treatment groups. In two of the groups, rats were unexposed to PSS but either...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001038
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:Skeletal muscle (SM), which is found mainly within the appendicular lean soft tissue (ALST) compartment, is a biological important body compartment. Simple and accurate methods to estimate both SM and ALST remain difficult to obtain. We aimed to develop and to cross-validate anthropometric models for ALST in at...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31818ffe4b
更新日期:2009-04-01 00:00:00
abstract:PURPOSE:To compare the effects of different patterns of regular brisk walking on fitness, risk factors for cardiovascular disease, and psychological well-being in previously sedentary adults. METHODS:Twenty-one subjects (14 women), aged 44.5 +/- 6.1 yr (mean +/- SD) were randomly assigned to two different, 6-wk progra...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00005768-200209000-00011
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Arterialization of venous gas emboli (VGE) formed after surfacing from SCUBA diving can become arterial gas emboli (AGE) through intrapulmonary arterial-venous anastomoses that open with exercise. METHODS:We recruited twenty patent foramen ovale-negative SCUBA divers and conducted a field and a laboratory...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000625
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To determine which combination of landing protocol and analysis technique would be the most effective at detecting differences in dynamic stability between healthy subjects and subjects with functional ankle instability (FAI). METHODS:Fifty-eight subjects participated in this investigation: 29 healthy individu...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000149887.84238.6c
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:Interval exercise training can elicit physiological adaptations similar to those of traditional endurance training, but with reduced time. However, the intense nature of specific protocols, particularly the "all-out" efforts characteristic of sprint interval training (SIT), may be perceived as being aversi...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1249/MSS.0000000000000494
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:To compare the total exercise loads (intensity x volume) of the Vuelta a España and Tour de France during the last year. METHODS:Seven professional road cyclists (28 +/- 1 yr; [OV0312]O(2max): 74.6 +/- 2.2 mL.kg-1.min-1) who participated in both Tour and Vuelta during the years 1997, 1999, 2000, or 2001 were c...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000064999.82036.B4
更新日期:2003-05-01 00:00:00
abstract:PURPOSE:To provide evidence that lower-extremity muscle activity during running is tuned in response to the loading rate of the impact forces at heel-strike. METHODS:Six runners ran two 30-min trials per week for 4 wk. The trials tested two shoes which differed only in the material hardness of the midsole. The shoes w...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200209000-00021
更新日期:2002-09-01 00:00:00
abstract:PURPOSE:This study aimed 1) to define the principal components of physical function assessed by 10 common lower extremity physical performance tests and 2) to derive a reduced-item set of physical performance tests that efficiently and accurately measures raw performance and limb symmetry on each underlying component i...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002422
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:It has been well established in mammals that circadian behavior as well as the molecular clockwork can be synchronized to the light-dark cycle via the suprachiasmatic nucleus of the hypothalamus (SCN). In addition to light, it has been demonstrated that nonphotic time cues, such as restricting the time of food ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318255cf4c
更新日期:2012-09-01 00:00:00
abstract::A variety of physiological responses, classified as local or central factors, have been suggested as providing the primary input for perception of effort during exercise. The potency of these responses as perceptual cues, however, has seldom been addressed in terms of relevant modifying variables such as exercise inte...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
abstract:PURPOSE:The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whet...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-200008000-00012
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:To compare the physiological and performance adaptations between periodized and nonperiodized resistance training in women collegiate tennis athletes. METHODS:Thirty women (19 +/- 1 yr) were assigned to either a periodized resistance training group (P), nonperiodized training group (NV), or a control group (C)...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-200301000-00024
更新日期:2003-01-01 00:00:00
abstract::Pyruvate and dihydroxyacetone are three carbon compounds that when infused directly into the blood or taken orally produce strong metabolic effects. When chronically fed to animals as part of their diet, pyruvate plus dihydroxyacetone reduce the rate of weight gain and body fat content during growth. These alterations...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,评审
doi:10.1097/00005768-199806000-00010
更新日期:1998-06-01 00:00:00