Abstract:
:In "normal" conditions (e.g., normoxia, absence of pathological conditions) convective and diffusive O(2) delivery to skeletal muscle fibers do not seem to represent important determinants for the kinetics of adjustment of oxidative phosphorylation following increases in metabolic demand. Whereas a limiting role by PDH has not been experimentally confirmed, inhibition of mitochondrial respiration by NO could be partially responsible for the delayed activation of oxidative phosphorylation at exercise onset. The main determinants of muscle VO(2) kinetics, however, likely reside in the intricate interplay between the various mechanisms of energy provision at exercise onset. By acting as high-capacitance energy buffers, PCr hydrolysis and anaerobic glycolysis would delay or attenuate the increase in [ADP] within the cell following rapid increases in ATP demand, thereby "buffering" a more rapid activation of oxidative phosphorylation. The "PCr-Cr shuttle" concept of a regulatory role of PCr or of the products of PCr hydrolysis on oxidative phosphorylation provides a mechanism that couples VO(2), which occurs in mitochondria, to PCr hydrolysis occurring in the cytoplasm.
journal_name
Med Sci Sports Exercjournal_title
Medicine and science in sports and exerciseauthors
Grassi Bdoi
10.1249/01.mss.0000177472.67419.0asubject
Has Abstractpub_date
2005-09-01 00:00:00pages
1567-73issue
9eissn
0195-9131issn
1530-0315pii
00005768-200509000-00017journal_volume
37pub_type
杂志文章,评审abstract:PURPOSE:Previous research identified decreased overall and cardiovascular mortality for National Football League (NFL) players from the 1959-1988 era. The present study explored the mortality risk among recent NFL players who played in an era of heavier linemen and nearly year-round physical conditioning. METHODS:This...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001466
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:The purpose of this study was to provide baseline data on immune status of exercising and sedentary exclusively lactating women. Dietary intake and body composition were also investigated to determine whether they related to immune function. METHODS:Healthy, exclusively breastfeeding women with a body mass ind...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000128245.39808.36
更新日期:2004-06-01 00:00:00
abstract::The present study was designed to assess the effects of acute exercise and short-term intensive training on catechol-O-methyltransferase (COMT) activity. COMT inactivates catecholamines and converts primary catecholestrogens (CE) into their O-methylated form yielding the 2- (2-MeOE) and 4-methoxyestrogens (4-MeOE). Bl...
journal_title:Medicine and science in sports and exercise
pub_type: 临床试验,杂志文章
doi:10.1097/00005768-199712000-00006
更新日期:1997-12-01 00:00:00
abstract:PURPOSE:The purposes of this study were 1) to add layers and features to a previously published fully automated algorithm designed to identify children's nocturnal sleep and to exclude episodes of nighttime nonwear/wakefulness and potentially misclassified daytime sleep episodes and 2) to validate this refined sleep al...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000486
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Physical activity (PA) promotion among youth is a public health priority, and there is a need for robust surveillance systems to help support such initiatives. Existing youth PA self-report instruments that are used for surveillance lack information regarding the types and contexts of activity. Further, these i...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001562
更新日期:2018-06-01 00:00:00
abstract::The effects of the potent opioid, sufentanil, were studied in 11 athletes. Sufentanil was administered intravenously (up to 0.5 microgram.kg-1 over 10 min) to the subjects while they ran at 14 km.hr-1 on a level treadmill. Prior to, and after, the drug infusion, the treadmill was inclined by 6% for 4 min and CO2 was i...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1988-12-01 00:00:00
abstract::To inform the development of bone-specific physical activity (PA) assessment methods and contribute to bone-specific PA guidelines, accelerometer outcomes that provide the most valid estimates of skeletal loading in adults must be identified. PURPOSE:The aims of this project were two-fold. First, to assess the concur...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000002562
更新日期:2020-11-07 00:00:00
abstract:PURPOSE:To examine longitudinal change in cardiorespiratory fitness and odds of incident sleep problems. METHODS:A cohort of 7368 men and 1155 women, age 20-85 yr, was recruited from the Aerobics Center Longitudinal Study. The cohort did not complain of sleep problems, depression, or anxiety at their first clinic visi...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000506
更新日期:2015-05-01 00:00:00
abstract:PURPOSE:Athletes occasionally follow pacing patterns that seem unreasonably aggressive compared with those of prerace performances, potentially because of the motivation provided by competition. This study evaluated the effect of extrinsic motivation on cyclists' time trial performance. METHODS:Well-trained recreation...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e31802eff36
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait. METHODS:In this study, we selected 1493 single-nucleot...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000889
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:We investigated the knee-extensor torque at which reoxygenation (inflow of arterial blood) during an isometric contraction stopped, whether this torque depended on maximal torque capacity (MTC), and whether there were differences among the synergists. METHODS:Isometric knee-extension torque was measured using ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e31802dd3cc
更新日期:2007-03-01 00:00:00
abstract:PURPOSE:This study aims to examine whether muscle glycogen availability is associated with fatigue in a repeated exercise bout following short-term recovery. METHODS:Ten endurance-trained individuals underwent two trials in a repeated-measures experimental design, each involving an initial run to exhaustion at 70% of ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000737
更新日期:2016-01-01 00:00:00
abstract:PURPOSE:Existing studies have failed to provide evidence of a positive effect on exercise performance by wearing compression short tights covering only both thighs. This could be due to an inadequate pressure intensity that otherwise has a significant effect if applied on the crucial point in the thigh. This study aime...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000330
更新日期:2014-11-01 00:00:00
abstract:PURPOSE:The purpose of this study was to determine the accuracy and reliability of the following electronic pedometers for measuring steps: Freestyle Pacer Pro (FR), Kenz Lifecorder (KZ), New Lifestyles NL-2000 (NL), Omron HJ-105 (OM), Oregon Scientific PE316CA (OR), Sportline 330 (SL330) and 345 (SL345), Walk4Life LS ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.MSS.0000089342.96098.C4
更新日期:2003-10-01 00:00:00
abstract:PURPOSE:To examine the effect of pelvic stabilization and two lower-limb configurations on the EMG activity of back and hip extensor muscles during a dynamic back extension exercise on a machine and to compare them between sexes. METHODS:Twenty-two healthy volunteers (11 men and 11 women) performed five trunk flexion-...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318188446a
更新日期:2009-02-01 00:00:00
abstract::To compare the physiological response to a cocaine-exercise challenge in cocaine-conditioned animals with that of acute-cocaine animals, rats were injected i.p. with either cocaine (20 mg.kg-1) or saline, twice daily for 14 consecutive days. On the 15th day (test day) cocaine-conditioned rats received an i.v. injectio...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE:Aerodynamic drag plays an important role in performance for athletes practicing sports that involve high-velocity motions. In giant slalom, the skier is continuously changing his/her body posture, and this affects the energy dissipated in aerodynamic drag. It is therefore important to quantify this energy to un...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e3182443315
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:Obesity in adolescence increases the risk for early adult cardiovascular disease. We recently showed that 6 months of diet, exercise, and metformin resulted in reductions in adiposity and that diet/exercise alone reduced proinflammatory factors and intrahepatic fat in pubertal children with uncomplicated obesit...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e31823cef5e
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:The development of valid measures of built environments relevant for physical activity is an important step toward controlling the global epidemic of physical inactivity-related noncommunicable diseases and deaths. This study assessed the construct validity of a self-report neighborhood environment walkability ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000001131
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:This study aimed to determine whether competitive intermittent exercise in the heat affects recovery, aggravates markers of muscle fiber damage, and delays the recovery of performance and muscle glycogen stores. METHODS:Plasma creatine kinase, serum myoglobin, muscle glycogen, and performance parameters (sprin...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e31827ded04
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To quantify variations in plantar pressure variables in healthy adults across five cardiovascular exercises. METHODS:Ten young (19-35 yr old) and 10 middle-aged (45-60 yr old) individuals participated. After equipment familiarization, plantar pressure data were recorded during walking, running, elliptical trai...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/mss.0b013e318148bdfa
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:beta2 adrenergic agonists are widely used as doping agents. Their side effects on bone, especially microarchitecture, remain unknown. The purpose of this study was to evaluate the effects of chronic clenbuterol and salbutamol treatment on bones of growing rats. METHODS:Twelve-week-old Wistar female rats were d...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/01.mss.0000177592.82507.95
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:Androgen deprivation therapy (ADT) is associated with significant bone loss and an increase in fracture risk among prostate cancer survivors (PCS). We investigated whether impact + resistance training could stop ADT-related declines in bone mineral density (BMD) among PCS on ADT. METHODS:We randomized 51 ...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0000000000000265
更新日期:2014-08-01 00:00:00
abstract:PURPOSE:The purpose of this study was to compare the predictive accuracy of previously published skinfold (SKF) equations for estimating body density of 134 premenopausal African-American women (18 to 40 yr). METHODS:The equations cross-validated were: the sum of seven skinfolds equation (JPW7) and the sum of three sk...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1097/00005768-199811000-00015
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:The primary study aim was to evaluate associations of estimated weekly minutes of moderate-to-vigorous-intensity exercise from self-reports of the telephone-administered 7-Day Physical Activity Recall (7-Day PAR) with data captured by the RT3 triaxial accelerometer. METHODS:This investigation was undertaken as...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,随机对照试验
doi:10.1249/MSS.0b013e3181984fa8
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:The significant sex disparity in sports-related knee injuries may be due to underlying differences in motor control. Although the development of sex-specific movement patterns is likely multifactorial, this study specifically focuses on the potential modulatory role of sex hormones. PURPOSE:This study aim...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000134
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:The goal of this study was to explore the effect of lifelong aerobic exercise (i.e., chronic training) on skeletal muscle substrate stores (intramyocellular triglyceride [IMTG] and glycogen), skeletal muscle phenotypes, and oxidative capacity (ox), in older endurance-trained master athletes (OA) compared with n...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0000000000000789
更新日期:2016-03-01 00:00:00
abstract:PURPOSE:To determine substrate utilization and energy expenditure during maximal and submaximal exercise and recovery in adolescents with cystic fibrosis (CF) and healthy age-matched controls (C). METHODS:Ten clinically stable CF patients (four girls, six boys; age = 10-22 yr) were matched by body mass index, age, gen...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:10.1249/MSS.0b013e318188449b
更新日期:2009-02-01 00:00:00
abstract::The purpose of this study was to determine whether efferent sympathetic nerve activity is different to resting skeletal muscles from the exercising and nonexercising limb. MSNA was measured by microneurography in both legs (peroneal nerve) in six subjects during 2 min of unilateral isometric knee extension (IKE; 10-30...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:PURPOSE:This study aimed to examine whether long-term fish oil (FO) supplementation is associated with a lower risk of mobility disability and enhances benefits of physical activity (PA). METHODS:A total of 1635 sedentary adults age 70 to 89 yr from the Lifestyle Interventions and Independence for Elders single-blinde...
journal_title:Medicine and science in sports and exercise
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1249/MSS.0000000000002195
更新日期:2020-04-01 00:00:00